Portal vein thrombosis laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]

Overview

Laboratory findings is usually normal among patients with portal vein thrombosis. In patients with cirrhosis, laboratory findings may demonstrate an elevated bilirubin, low platelet count, prolonged international normalized ratio (INR), or renal insufficiency.

Laboratory Findings

Laboratory findings of portal vein thrombosis will be normal or quite normal, unless there is coexistence of a liver disease.
Although, coagulation factors levels could be moderately decreased, while D-dimer level is usually increased.
In some patients laboratory findings may show moderate increase in serum aminotransferases.^[1]^[2]^[3]
In patients with cirrhosis, laboratory findings may demonstrate an elevated bilirubin, low platelet count, prolonged international normalized ratio (INR), or renal insufficiency.
Blood cultures of septic portal vein are often positive for Bacteroides fragilis or Escherichia coli, also other pathogens have been cultured.^[4]

References

↑ Ponziani FR, Zocco MA, Campanale C, Rinninella E, Tortora A, Di Maurizio L, Bombardieri G, De Cristofaro R, De Gaetano AM, Landolfi R, Gasbarrini A (2010). “Portal vein thrombosis: insight into physiopathology, diagnosis, and treatment”. World J. Gastroenterol. 16 (2): 143–55. PMC 2806552. PMID 20066733.
↑ Condat B, Valla D (2006). “Nonmalignant portal vein thrombosis in adults”. Nat Clin Pract Gastroenterol Hepatol. 3 (9): 505–15. doi:10.1038/ncpgasthep0577. PMID 16951667.
↑ Zhang WW, Churchill S, Churchill P (1989). “Developmental regulation of D-beta-hydroxybutyrate dehydrogenase in rat liver and brain”. FEBS Lett. 256 (1–2): 71–4. PMID 2806552.
↑ Plemmons RM, Dooley DP, Longfield RN (1995). “Septic thrombophlebitis of the portal vein (pylephlebitis): diagnosis and management in the modern era”. Clin. Infect. Dis. 21 (5): 1114–20. PMID 8589130.

Overview