Postpartum thyroiditis risk factors

The most potent risk factors in the development of postpartum thyroiditis (PPT) are genetic abnormalities and subsequent pregnancies. Other risk factors for postpartum thyroiditis include smoking, increase or decreased intake of iodine, hepatitis C, radiations and medications.

Various factors associated with the development of PPT can be categorized into common and less common risk factors.^[1]

• Common risk factors in the development of PPT is genetic abnormalities in:
  • CD60 CTLA-4 gene
  • HLA DR3 haplotype
  • HLA DR4 haplotype
  • HLA DR5 haplotype

• Subsequent pregnancies are also a common risk factor for the development of postpartum thyroiditis.

• Less common risk factors in the development of postpartum thyroiditis (PPT) include:
  1. Smoking
  2. Intake of Iodine
  3. Radiation
  4. Medications:
     • Lithium
     • Amiodarone
     • Interferon alpha
     • Interleukin 2
     • Highly active anti-retro-viral therapy
  5. Systemic lupus erythromatosis
  6. Multiple Sclerosis
  7. Thyroid hormone resistance syndrome

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