Primary amyloidosis history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]Shyam Patel [3] Syed Hassan A. Kazmi BSc, MD [4]

Overview

In primary amyloidosis, the range of symptoms depends on specific tissues and organs involved. Symptoms can be quite diverse.

History and Symptoms

History

Patients with amyloidosis may have a positive history of:^[1]^[2]

Symtoms

Common Symptoms

Common symptoms in patients with primary amyloidosis include:^[1]^[3]^[4]^[5]^[6]

Less Common Symptoms

Less common symptoms in patients with primary amyloidosis include:^[7]^[8]^[9]^[10]

References

↑ ^1.0 ^1.1 Mahmood S, Palladini G, Sanchorawala V, Wechalekar A (February 2014). “Update on treatment of light chain amyloidosis”. Haematologica. 99 (2): 209–21. doi:10.3324/haematol.2013.087619. PMC 3912950. PMID 24497558.
↑ Cichoż-Lach H, Prozorow-Król B, Swatek J, Skrzydło-Radomańska B, Buk L, Zdunek M, Kowalik A, Słomka M (2014). “Hepatomegaly, weight loss and general malaise – the first manifestations of primary systemic amyloidosis”. Prz Gastroenterol. 9 (1): 57–61. doi:10.5114/pg.2014.40853. PMC 4027848. PMID 24868301.
↑ Shin SC, Robinson-Papp J (2012). “Amyloid neuropathies”. Mt. Sinai J. Med. 79 (6): 733–48. doi:10.1002/msj.21352. PMC 3531896. PMID 23239211.
↑ Rajkumar SV, Gertz MA, Kyle RA (March 1998). “Prognosis of patients with primary systemic amyloidosis who present with dominant neuropathy”. Am. J. Med. 104 (3): 232–7. doi:10.1016/s0002-9343(98)00037-0. PMID 9552085.
↑ Dixit R, Gupta R, Dave L, Prasad N, Sharma S (April 2009). “Clinical profile of patients having pulmonary tuberculosis and renal amyloidosis”. Lung India. 26 (2): 41–5. doi:10.4103/0970-2113.48896. PMC 2860413. PMID 20440393.
↑ Morais G, Arruda MM, Bonadia J, Pozzan G (2014). “Cardiac amyloidosis: a challenging diagnosis”. Autops Case Rep. 4 (4): 9–17. doi:10.4322/acr.2014.034. PMC 5443128. PMID 28573124. Vancouver style error: initials (help)
↑ Thibault I, Vallières I (May 2011). “Macroglossia due to Systemic Amyloidosis: Is There a Role for Radiotherapy?”. Case Rep Oncol. 4 (2): 392–9. doi:10.1159/000330238. PMC 3177795. PMID 21941488.
↑ Yiotakis I, Georgolios A, Charalabopoulos A, Hatzipantelis P, Golias C, Charalabopoulos K, Manolopoulos L (September 2009). “Primary localized laryngeal amyloidosis presenting with hoarseness and dysphagia: a case report”. J Med Case Rep. 3: 9049. doi:10.4076/1752-1947-3-9049. PMC 2767149. PMID 19918287.
↑ Rowe K, Pankow J, Nehme F, Salyers W (May 2017). “Gastrointestinal Amyloidosis: Review of the Literature”. Cureus. 9 (5): e1228. doi:10.7759/cureus.1228. PMC 5464793. PMID 28611935.
↑ McMahan ZH, Sailors JL, Toto R, Olsen NJ (January 2010). “Systemic amyloidosis presenting as chronic diarrhea in a patient with ankylosing spondylitis”. J Clin Rheumatol. 16 (1): 22–5. doi:10.1097/RHU.0b013e3181c78c1a. PMID 20051751.

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[pmid24497558-1] 1.0 ^1.1 Mahmood S, Palladini G, Sanchorawala V, Wechalekar A (February 2014). “Update on treatment of light chain amyloidosis”. Haematologica. 99 (2): 209–21. doi:10.3324/haematol.2013.087619. PMC 3912950. PMID 24497558.

[pmid24868301-2] Cichoż-Lach H, Prozorow-Król B, Swatek J, Skrzydło-Radomańska B, Buk L, Zdunek M, Kowalik A, Słomka M (2014). “Hepatomegaly, weight loss and general malaise – the first manifestations of primary systemic amyloidosis”. Prz Gastroenterol. 9 (1): 57–61. doi:10.5114/pg.2014.40853. PMC 4027848. PMID 24868301.

[pmid23239211-3] Shin SC, Robinson-Papp J (2012). “Amyloid neuropathies”. Mt. Sinai J. Med. 79 (6): 733–48. doi:10.1002/msj.21352. PMC 3531896. PMID 23239211.

[pmid9552085-4] Rajkumar SV, Gertz MA, Kyle RA (March 1998). “Prognosis of patients with primary systemic amyloidosis who present with dominant neuropathy”. Am. J. Med. 104 (3): 232–7. doi:10.1016/s0002-9343(98)00037-0. PMID 9552085.

[pmid20440393-5] Dixit R, Gupta R, Dave L, Prasad N, Sharma S (April 2009). “Clinical profile of patients having pulmonary tuberculosis and renal amyloidosis”. Lung India. 26 (2): 41–5. doi:10.4103/0970-2113.48896. PMC 2860413. PMID 20440393.

[pmid28573124-6] Morais G, Arruda MM, Bonadia J, Pozzan G (2014). “Cardiac amyloidosis: a challenging diagnosis”. Autops Case Rep. 4 (4): 9–17. doi:10.4322/acr.2014.034. PMC 5443128. PMID 28573124. Vancouver style error: initials (help)

[pmid21941488-7] Thibault I, Vallières I (May 2011). “Macroglossia due to Systemic Amyloidosis: Is There a Role for Radiotherapy?”. Case Rep Oncol. 4 (2): 392–9. doi:10.1159/000330238. PMC 3177795. PMID 21941488.

[pmid19918287-8] Yiotakis I, Georgolios A, Charalabopoulos A, Hatzipantelis P, Golias C, Charalabopoulos K, Manolopoulos L (September 2009). “Primary localized laryngeal amyloidosis presenting with hoarseness and dysphagia: a case report”. J Med Case Rep. 3: 9049. doi:10.4076/1752-1947-3-9049. PMC 2767149. PMID 19918287.

[pmid28611935-9] Rowe K, Pankow J, Nehme F, Salyers W (May 2017). “Gastrointestinal Amyloidosis: Review of the Literature”. Cureus. 9 (5): e1228. doi:10.7759/cureus.1228. PMC 5464793. PMID 28611935.

[pmid20051751-10] McMahan ZH, Sailors JL, Toto R, Olsen NJ (January 2010). “Systemic amyloidosis presenting as chronic diarrhea in a patient with ankylosing spondylitis”. J Clin Rheumatol. 16 (1): 22–5. doi:10.1097/RHU.0b013e3181c78c1a. PMID 20051751.

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