Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Macroglossia
Introduction
Overview
Overview
The common causes of macroglossia include acromegaly, amyloidosis, beckwith-Wiedemann syndrome, congenital hypothyroidism and down syndrome.
Causes
Causes
Life Threatening Causes
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
Common Causes
- Acromegaly
- Amyloidosis
- Beckwith-Wiedemann syndrome
- Congenital hypothyroidism
- Down syndrome
- Hurler syndrome
- I-cell disease
Causes by Organ System
| Cardiovascular | Cardiac amyloidosis |
| Chemical / poisoning | No underlying causes |
| Dermatologic | Hemangioma |
| Drug Side Effect | Angioedema |
| Ear Nose Throat | Acromegaly |
| Endocrine | Acromegaly, congenital hypothyroidism, growth hormone secreting pituitary adenoma, hypothyroidism |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | Alpha-mannosidosis, Beckwith-Wiedemann syndrome, chromosome 12p tetrasomy syndrome, chromosome 9q deletion syndrome, congenital micrognathia, down syndrome, gM1 gangliosidoses, gM3 gangliosidoses, glycogen storage disease, Hunter syndrome, Hurler syndrome, Limb-girdle muscular dystrophy, lymphoma, monoclonal gammopathy of undetermined significance, I-cell disease, omphalocele, Smith-Lemli-Opitz syndrome, Pompe disease, Potocki-Lupski syndrome, Simpson-Golabi-Behmel syndrome, tongue cancer |
| Hematologic | Multiple myeloma, monoclonal gammopathy of undetermined significance, lymphoma, down syndrome |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal / Ortho | Acromegaly, Beckwith-Wiedemann syndrome, congenital hypothyroidism, cystic hygroma, Limb-girdle muscular dystrophy, multiple myeloma, sleep apnea, Simpson-Golabi-Behmel syndrome, Beckwith-Wiedemann syndrome, tongue cancer |
| Neurologic | Neurofibromatosis |
| Nutritional / Metabolic | Cardiac amyloidosis, amyloidosis, gM1 gangliosidoses, gM3 gangliosidoses, Hunter syndrome, immunoglobulin light chain amyloidosis, I-cell disease, Pompe disease, Potocki-Lupski syndrome |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | Hemangioma |
| Ophthalmologic | No underlying causes |
| Overdose / Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal / Electrolyte | No underlying causes |
| Rheum / Immune / Allergy | Angioedema |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | Sleep apnea |
Causes in Alphabetical Order
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Carlos A Lopez, M.D. [2]