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Primary amyloidosis physical examination

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Jesus Rosario Hernandez, M.D. [2]

Overview

Overview

Common findings in primary amyloidosis include petechiae, ecchymosis, parotid gland enlargement, increased intraocular pressure, enlarged tongue, hepatomegaly, carpal tunnel syndrome, and Raynaud’s phenomenon.

Physical Examination

Physical Examination

Vitals

Skin

  • The most common skin findings are
    • Petechiae (small red blood spots).
    • Ecchymoses (small, flat blood spots that are round or irregular shape and bluish/purplish in colour)
    • Waxy papular nodules can be seen around the eye lids, neck and also in the groin.
    • Brittle nails.
    • Edema due to heart failure
    • Patches of hair loss can be seen.
  • Nail dystrophy
  • Cutis laxa[1]

Ear

Eyes

  • Raised intraocular pressure may be present.
  • Peri-orbital purpura[1]

Throat

Abdomen

Extremities

Macular Amyloidosis

Nodular Amyloidosis

References

References

  1. ↑ 1.0 1.1 1.2 Wechalekar AD, Gillmore JD, Hawkins PN (June 2016). “Systemic amyloidosis”. Lancet. 387 (10038): 2641–2654. doi:10.1016/S0140-6736(15)01274-X. PMID 26719234.

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