Raynaud's phenomenon
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Editors-In-Chief: Asghar Fakhri, M.D.; Duane S. Pinto, M.D. and C. Michael Gibson, M.S., M.D.
Synonyms and keywords: Raynaud phenomenon; Raynaud’s disease
Overview
Editors-In-Chief: Asghar Fakhri, M.D., Duane S. Pinto, M.D. and C. Michael Gibson, M.S., M.D.
Overview
Raynaud’s phenomenon (RAY-noz), in medicine, is a vasospastic disorder causing discoloration of the fingers, toes, and occasionally other extremities, named for French physician Maurice Raynaud (1834 – 1881). The cause of the phenomenon is unknown, but emotional stress and cold are classically triggers, and the discoloration follows a characteristic pattern in time: white, blue and red. It comprises both Raynaud’s disease (primary Raynaud’s), where the phenomenon is idiopathic, and Raynaud’s syndrome (secondary Raynaud’s), where it is secondary to something else.
References
Pathophysiology
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References
Causes
Editors-In-Chief: Asghar Fakhri, M.D., Duane S. Pinto, M.D. and C. Michael Gibson, M.S., M.D.
Overview
Causes
Causes by Organ System
Causes in Alphabetical Order
It is important to realise that Raynaud’s can herald these diseases by periods of more than 20 years in some cases, making it effectively their first presenting symptom. This can be the case in the CREST syndrome, of which Raynaud’s is a part.
References
Differentiating Raynaud’s phenomenon from other Diseases
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References
Epidemiology and Demographics
Editors-In-Chief: Asghar Fakhri, M.D., Duane S. Pinto, M.D. and C. Michael Gibson, M.S., M.D.
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Overview
Age
There is a familial component to primary Raynaud’s, and presentation is typically before 30.
Gender
The phenomenon is more common in women than men, with the Framingham Study finding that 5.8% of men and 9.6% of women suffered from it.
References
Risk Factors
Editors-In-Chief: Asghar Fakhri, M.D., Duane S. Pinto, M.D. and C. Michael Gibson, M.S., M.D.
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Overview
Risk Factors
Smoking worsens frequency and intensity of attacks, and there is a hormonal component. Raynaud’s phenomenon also occurs without another disease, medication, or cause. This is called primary Raynaud’s phenomenon. It most often begins in people younger than age 30.
Reference
Natural History, Complications and Prognosis
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Natural History
Complications
- Gangrene or skin ulcers may occur if an artery becomes completely blocked (most likely to occur in people who also have arthritis or autoimmune conditions)
- Permanently decreased blood flow to the area can lead to thin and tapered fingers, with smooth, shiny skin and slow growing nails
Prognosis
The outcome varies depending on the cause and the severity of the condition.
References
Diagnosis
Diagnosis
History and Symptoms | Physical Examination | Laboratory Findings | Other diagnostic studies
Treatment
Treatment
Medical therapy | Primary prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies
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