Primary central nervous system lymphoma risk factors

The most potent risk factor in the development of primary central nervous system lymphoma is a weakened or suppressed immune system in individuals who have acquired immunodeficiency syndrome (AIDS), received an organ transplant and are on immunosuppressants, inherited immunosuppressive disorders (IgA deficiency, Wiskott-Aldrich syndrome, ataxia telangiectasia), and autoimmune disorders (systemic lupus erythematosus, rheumatoid arthritis, myasthenia gravis).

The most potent risk factor in the development of primary central nervous system lymphoma is a weakened or suppressed immune system in individuals who have:^[1][2][3][4]

• Acquired immunodeficiency syndrome (AIDS)

• The highest number of cases occur in individuals with AIDS.

• Received an organ transplant and are on immunosuppressants
• Inherited immunosuppressive disorder

• IgA deficiency
• Wiskott-Aldrich syndrome
• Ataxia telangiectasia
• Severe combined immunodeficiency (SCID)
• Common variable immunodeficiency (CVID)

• Autoimmune disorders

• Systemic lupus erythematosus
• Rheumatoid arthritis
• Sjögren’s syndrome
• Myasthenia gravis
• Sarcoidosis
• Vasculitis

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