Pseudomyxoma peritonei is a rare disease caused by a pre-existing intraperitoneal mucinous neoplasm, accumulation of fluids in abdominal cavity causes mass impact on vital organs such as the spleen, kidney, and pancreas. The pathology and causes of pseudomyxoma peritonei are poorly understood. It is shown in some studies that the K-Ras and p53 genes may be involved in the oncogenesis.

• Studies have shown and supported that pseudomyxoma peritonei arises from primary appendiceal neoplasm rather than ovarian or colon.^[1]
• The primary tumor appears to arise from the MUC2 expressing goblet cells and most commonly from these cells in the appendix.^[2]
• The K-Ras and p53 genes may be involved in the oncogenesis. It was shown in studies that overexpression of p53 was in correlation with female sex, highe-grade disease, and worse survival.^[3]

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