Renal papillary necrosis causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nasrin Nikravangolsefid, MD-MPH [2]
Overview
Overview
- Renal papillary necrosis is associated with damaging the renal medullary and papillary cells due to many diseases such as diabetes, sickle cell disease, urinary tract obstruction, renal vein thrombosis, pyelonephritis, tuberculosis, vasculitis, cirrhosis, renal transplant rejection and long term analgesics and alcohol abuse. In infants, it is associated with asphyxia, dehydration, and sepsis.
Causes
Causes
- Common causes of renal papillary necrosis include[1][2][3]:
- Diabetes
- Sickle cell disease: most common cause in children
- Urinary tract obstruction
- Renal vein thrombosis
- upper urinary tract infection or pyelonephritis
- Tuberculosis
- liver cirrhosis
- systemic vasculitis
- Renal transplant rejection
- chronic alcohol abuse
- abuse of acetaminophen and analgesics containing phenacetin such as NSAIDs
- Renal papillary necrosis may also occur less commonly in infants due to[4]:
- There is a mnemonic for the causes of renal papillary necrosis[5] : POSTCARDS:
- Pyelonephritis
- Obstruction of the urogenital tract
- Sickle cell disease
- Tuberculosis
- Cirrhosis
- Analgesia/Alcohol abuse
- Renal vein thrombosis
- Diabetes mellitus
- Systemic vasculitis
References
References
- ↑ Brix AE (2002). “Renal papillary necrosis”. Toxicol Pathol. 30 (6): 672–4. doi:10.1080/01926230290166760. PMID 12512867.
- ↑ Sabatini S (1984). “Pathophysiology of drug-induced papillary necrosis”. Fundam Appl Toxicol. 4 (6): 909–21. doi:10.1016/0272-0590(84)90229-x. PMID 6394414.
- ↑ Henderickx MMEL, Brits T, De Baets K, Seghers M, Maes P, Trouet D; et al. (2017). “Renal papillary necrosis in patients with sickle cell disease: How to recognize this ‘forgotten’ diagnosis”. J Pediatr Urol. 13 (3): 250–256. doi:10.1016/j.jpurol.2017.01.020. PMID 28341428.
- ↑ Husband P, Howlett KA (1973). “Renal papillary necrosis in infancy”. Arch Dis Child. 48 (2): 116–20. doi:10.1136/adc.48.2.116. PMC 1648192. PMID 4690507.
- ↑ Kim, Seung Hyup (2011-11-19). Radiology Illustrated: Uroradiology. Springer Science & Business Media. p. 471. ISBN 9783642053221.
[[Category:Disease]
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