Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Sjögren's syndrome history and symptoms
Introduction
Overview
Overview
The most common symptoms of Sjögren’s syndrome include ocular and oral symptoms. Patients with Sjögren’s syndrome may have a positive history of rheumatoid arthritis (RA), systemic lupus erythematous (SLE) and non-Hodgkin B-cell lymphoma.
History and Symptoms
History and Symptoms
History
Patients with Sjögren’s syndrome may have positive past and family history of:
Common Symptoms
Common symptoms of Sjögren’s syndrome include:[1][2][3][4][5][6][7][8][9][10]
- Skin manifestations
- Xerosis
- Purpura, associated with vascular or hematologic abnormalities
- Raynaud phenomenon
- Cutaneous vasculitis
- Annular erythema
- Erythema nodosum
- Livedo reticularis
- Lichen planus
- Vitiligo
- Cutaneous amyloidosis
- Granuloma annulare
- Angular cheilitis
- Eyelid dermatitis
- Musculoskeletal manifestations
- Fatigue and fibromyalgia
- Pulmonary symptoms
- Dryness of the tracheobronchial mucosa (xerotrachea)
- Dry cough
- Recurrent bronchitis
- Pneumonitis (infectious or noninfectious)
- Dyspnea from interstitial lung disease
- Gastrointestinal manifestations
- Dysphagia
- Nausea
- Dyspepsia and gastritis
- Celiac disease
- Hepatic abnormalities
- subclinical pancreatic disease
- Cardiac involvement
- Pericarditis
- Pulmonary hypertension
- Dysfunction of autonomic control of blood pressure
- Myocardial disease
- Neurologic and psychiatric symptoms
- Myelopathy
- Optic neuropathy
- Seizures
- Cognitive dysfunction
- Encephalopathy
- Painful sensory neuropathy
- Sensory ataxic neuropathy
- Pure sensory trigeminal neuropathy
- Axonal sensorimotor polyneuropathy
- Mononeuritis multiplex
- Multiple cranial neuropathies
- Radiculoneuropathy
- Autonomic neuropathy
- Depression
- Urogenital manifestations
- Interstitial nephritis
- Interstitial cystitis
- Vulvovaginal dryness, pruritus, and dyspareunia
- Parotitis
- Vasculitis
- Hematologic manifestations
- Anemia
- Leukopenia
- Mild thrombocytopenia
- Hypergammaglobulinemia and hypogammaglobulinemia
- Thyroid disease
- Autoimmune thyroiditis
References
References
- ↑ Kittridge A, Routhouska SB, Korman NJ (2011). “Dermatologic manifestations of Sjögren syndrome”. J Cutan Med Surg. 15 (1): 8–14. doi:10.2310/7750.2010.09033. PMID 21291650.
- ↑ Roguedas AM, Misery L, Sassolas B, Le Masson G, Pennec YL, Youinou P (2004). “Cutaneous manifestations of primary Sjögren’s syndrome are underestimated”. Clin. Exp. Rheumatol. 22 (5): 632–6. PMID 15485020.
- ↑ Baimpa E, Dahabreh IJ, Voulgarelis M, Moutsopoulos HM (September 2009). “Hematologic manifestations and predictors of lymphoma development in primary Sjögren syndrome: clinical and pathophysiologic aspects”. Medicine (Baltimore). 88 (5): 284–93. doi:10.1097/MD.0b013e3181b76ab5. PMID 19745687.
- ↑ Amezcua-Guerra LM, Hofmann F, Vargas A, Rodriguez-Henriquez P, Solano C, Hernández-Díaz C, Castillo-Martinez D, Ventura-Ríos L, Gutiérrez M, Pineda C (2013). “Joint involvement in primary Sjögren’s syndrome: an ultrasound “target area approach to arthritis““. Biomed Res Int. 2013: 640265. doi:10.1155/2013/640265. PMC 3722787. PMID 23936829.
- ↑ Kanellopoulos P, Baltoyiannis C, Tzioufas AG (April 2002). “Primary Sjögren’s syndrome associated with inclusion body myositis”. Rheumatology (Oxford). 41 (4): 440–4. PMID 11961175.
- ↑ Pérez B, Kraus A, López G, Cifuentes M, Alarcón-Segovia D (November 1995). “Autoimmune thyroid disease in primary Sjögren’s syndrome”. Am. J. Med. 99 (5): 480–4. PMID 7485204.
- ↑ Ramirez-Mata M, Pena Ancira FF, Alarcon-Segovia D (March 1976). “Abnormal esophageal motility in primary Sjögren’s syndrome”. J. Rheumatol. 3 (1): 63–9. PMID 1271390.
- ↑ Lehrer S, Bogursky E, Yemini M, Kase NG, Birkenfeld A (March 1994). “Gynecologic manifestations of Sjögren’s syndrome”. Am. J. Obstet. Gynecol. 170 (3): 835–7. PMID 8141212.
- ↑ Binder A, Snaith ML, Isenberg D (August 1988). “Sjögren’s syndrome: a study of its neurological complications”. Br. J. Rheumatol. 27 (4): 275–80. PMID 3261608.
- ↑ Ramos-Casals M, Font J, Garcia-Carrasco M, Brito MP, Rosas J, Calvo-Alen J, Pallares L, Cervera R, Ingelmo M (July 2002). “Primary Sjögren syndrome: hematologic patterns of disease expression”. Medicine (Baltimore). 81 (4): 281–92. PMID 12169883.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]