Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Staphylococcal scalded skin syndrome pathophysiology
Introduction
Please help WikiDoc by adding more content here. It’s easy! Click here to learn about editing.
Overview
Overview
The syndrome is induced by epidermolytic exotoxins (exfoliatin)[1] A and B, which are released by S. aureus and cause detachment within the epidermal layer; by breaking down tight-junctions. One of the exotoxins is produced by the bacterial chromosome, while the other is produced by a plasmid. (Bacterial plasmids are pieces of self-replicating DNA that often code for secondary characteristics, such as antibiotic resistance, and toxin production.) These exotoxins are proteases that cleave desmoglein-1, which normally holds the granulosum and spinosum layers together.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]