Testicular cancer classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2], Shanshan Cen, M.D. [3]

Overview

Testicular cancer is a very rare type of cancer. Based on the histopathological features, testicular cancer may be classified into six subtypes: germ cell tumors, sex–cord stromal tumors, tumors containing both germ cell and sex–cord stromal elements, miscellaneous tumors of the testis, hematolymphoid tumors, and tumors of collecting duct and rete testis.

Classification

WHO Classification of testicular Tumors

WHO classifies testicular tumors as follows:^[1]^[2]

Testicular Cancer
Germ cell tumors	Sex-cord stromal tumors	Miscellaneous tumors of the testis	Hematolymphoid tumors	Tumors of collecting duct and rete testis	Tumors containing both germ cell and sex-cord stromal elements
Germ cell tumors derived from germ cell neoplasia in situ: Non-invasive germ cell neoplasia Germ cell neoplasia in situ Specific forms of intratubular germ cell tumor neoplasia Tumors of a single histological type (pure forms) Seminoma Seminoma with syncytiotrophoblast cells Non-seminomatous germ cell tumors Embryonal carcinoma Yolk sac tumor, postpubertal-type Trophoblastic tumors Choriocarcinoma Non-choriocarcinomatous trophoblastic tumors Placental site trophoblastic tumor Epitheliol trophoblastic tumor Cystic trophoblastic tumor Teratoma, postpubertal-type Teratoma with somatic-type Non-seminomatous germ cell type tumor of more than one histological type Mixed germ cell tumors Germ cell tumors of unknown type Regressed germ cell tumors Germ cell tumors unrelated to germ cell neoplasia in situ: Spermatocytic tumor Teratoma, prepubertal-type Dermoid cyst Epidermoid cyst Well-differentiated neuroendocrine tumor (monodermal teratoma) Mixed teratoma and yolk sac tumor, prepubertal-type Yolk sac tumor, prepubertal-type	Pure tumors Leydig cell tumor Malignant leydig cell tumor Sertoli cell tumor Malignant Sertoli cell tumor Large cell calcifying Sertoli cell tumor Intratubular large cell hyalinizing Sertoli cell neoplasia Granulosa cell tumor Adult granulosa cell tumor Juvenile granulosa cell tumor Tumors in the fibroma–thecoma group Mixed and unclassified sex-stromal tumors Mixed sex cord-stromal tumor Unclassified sex cord-stromal tumor	Ovarian epithelial-type tumors Serous cystadenoma Serous tumor of borderline malignancy Serous cystadenocarcinoma Mucinous borderline tumor Mucinous cystadenocarcinoma Endometrioid adenocarcinoma Clear cell adenocarcinoma Brenner tumor Juvenile Xanthogranuloma Hemangioma	Diffuse large B-cell lymphoma Follicular lymphoma, NOS Extranodal NK/T-cell lymphoma, nasal type Plasmacytoma Myeloid sarcoma Rosai-Dorfman disease	Adenoma Adenocarcinoma	Gonadoblastoma

References

↑ Williamson SR, Delahunt B, Magi-Galluzzi C, Algaba F, Egevad L, Ulbright TM, Tickoo SK, Srigley JR, Epstein JI, Berney DM (February 2017). “The World Health Organization 2016 classification of testicular germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel”. Histopathology. 70 (3): 335–346. doi:10.1111/his.13102. PMID 27747907.
↑ Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM (July 2016). “The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours”. Eur. Urol. 70 (1): 93–105. doi:10.1016/j.eururo.2016.02.029. PMID 26935559.

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[pmid27747907-1] Williamson SR, Delahunt B, Magi-Galluzzi C, Algaba F, Egevad L, Ulbright TM, Tickoo SK, Srigley JR, Epstein JI, Berney DM (February 2017). “The World Health Organization 2016 classification of testicular germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel”. Histopathology. 70 (3): 335–346. doi:10.1111/his.13102. PMID 27747907.

[pmid26935559-2] Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM (July 2016). “The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours”. Eur. Urol. 70 (1): 93–105. doi:10.1016/j.eururo.2016.02.029. PMID 26935559.

[1]

[2]

Testicular cancer classification

Overview

Classification

WHO Classification of testicular Tumors

References

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