Trousseau sign of latent tetany is a medical sign observed in patients with low calcium.^[1] This sign may become positive before other gross manifestations of hypocalcemia such as hyperreflexia and tetany, as such it is generally believed to be more sensitive (94%) than the Chvostek sign (29%) for hypocalcemia.^[2][3]

To elicit the sign, a blood pressure cuff is placed around the arm and inflated to a pressure greater than the systolic blood pressure and held in place for 3 minutes. This will occlude the brachial artery. In the absence of blood flow, the patient’s hypocalcemia and subsequent neuromuscular irritability will induce spasm of the muscles of the hand and forearm. The wrist and metacarpophalangeal joints flex, the DIP and PIP joints extend, and the fingers adduct. The sign is also known as main d’accoucheur (French for “hand of the obstetrician“) because it supposedly resembles the position of an obstetrician’s hand in delivering a baby.

The sign is named after French physician Armand Trousseau who described the phenomenon in 1861.^[4] It is distinct from the Trousseau sign of malignancy.