Trypanosome

Trypanosomes are a group of kinetoplastid protozoa distinguished by having only a single flagellum. All members are exclusively parasitic, found primarily in insects. A few genera have life-cycles involving a secondary host, which may be a vertebrate or a plant. These include several species that cause major diseases in humans.

The most notable trypanosomal diseases are trypanosomiasis (African Sleeping Sickness and South American Chagas Disease); these are caused by species of Trypanosoma. Leishmaniasis is a trypanosomal disease caused by species of Leishmania.

A variety of different forms appear in the life-cycles of trypanosomes, distinguished mainly by the position of the flagellum:

All trypanosomes have at least amastigote and promastigote stages. Trypanosoma appears in all five forms, with the trypanosomal stage occurring in the vertebrate host. Trypanosoma brucei sub-species have two forms in the bloodstream of a vertebrate host, the rapidly dividing long-slender form and the non-dividing short stumpy form. The short stumpy parasites are adapted for uptake into the tsetse fly vector, and are non-proliferative in comparison with the slender forms.

Unique to Trypansoma brucei is the expression of a variable surface glycoprotein (VSG) coat on the cell surface, which undergoes constant variation in order to evade the humoral immune system and host antibodies. It is thought that recombination from a repertoire of >1000 VSG genes is responsible for the vast diversity of the parasite, and its effectiveness in immune evasion.

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