Health Dictionary
Reliable, easy-to-read patient information on common medical conditions β written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Antiphospholipid syndrome laboratory findings
Introduction
Overview
Overview
Antiphospholipid syndrome (APS) is tested for in the laboratory by both liquid phase coagulation assays (lupus anticoagulant) and solid phase ELISA assays (anti-cardiolipin antibodies). Antibodies found in the plasma os patients with APS are lupus anticoagulant, anticariolipin (aCL), beta-2 glycoprotein I, anti-phosphatidylserine antibodies, anti-prothrombin antibodies. The criteria for testing antiphospholipid antibodies in the plasma is postivity on 2 or more occasion at least 12 weeks apart.
Laboratory Findings
Laboratory Findings
The following antibodies are found in the plasma of patients with APS:[1][2][3][4]
| Laboratory Findings (Antibodies) |
|---|
|
Criteria for testing Antiphospholipid antibodies:
- Presence of lupus anticoagulant (LA) in plasma on two or more occasions minimum 12 weeks apart.
- Presence of moderate to high levels of anticardiolipin (aCL) (IgG or IgM) in serum or plasma on two or more occasions minimum 12 weeks apart.
- Presence of moderate to high levels of antiβbeta-2 glycoprotein I antibodies (IgG or IgM) in plasma or serum on two or more occasions minimum 12 weeks apart.
| Common Laboratory findings |
|---|
|
References
References
- β Giannakopoulos B, Passam F, Ioannou Y, Krilis SA (2009). “How we diagnose the antiphospholipid syndrome”. Blood. 113 (5): 985β94. doi:10.1182/blood-2007-12-129627. PMIDΒ 18755986.
- β Galli M (2008). “Clinical utility of laboratory tests used to identify antiphospholipid antibodies and to diagnose the antiphospholipid syndrome”. Semin Thromb Hemost. 34 (4): 329β34. doi:10.1055/s-0028-1085474. PMIDΒ 18814065.
- β Li R, Daguzan M, Vandermijnsbrugge F, Gyling M, Cantinieaux B (2014). “Both IgG and IgM anti-beta2 glycoprotein I antibodies assays are clinically useful to the antiphospholipid syndrome diagnosis”. Acta Clin Belg. 69 (6): 433β8. doi:10.1179/2295333714Y.0000000060. PMIDΒ 25103595.
- β Musial J, Swadzba J, Motyl A, Iwaniec T (2003). “Clinical significance of antiphospholipid protein antibodies. Receiver operating characteristics plot analysis”. J Rheumatol. 30 (4): 723β30. PMIDΒ 12672190.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Feham Tariq, MD [2]