Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Breast lumps classification
Introduction
Overview
Overview
Breast lumps may be classified according to epithelial hyperplasia into 3 subtypes: non-proliferative, proliferative disease and proliferative disease without atypia. Breast lumps may be classified into 3 sub-types based on histological regions: lobular region, ductal region, different origins.
Classification
Classification
Classification of breast lumps based on epithelial hyperplasia:[1][2][3]
- Approximately 65% of all benign breast disease considered as non-proliferative (NP) with relative cancer risk of 1.2 – 1.4 times:
- Cyst (most common)[4]
- Fibrosis
- Fibroadenoma (simple)
- Columnar alteration (Simple)
- Apocrine metaplasia (simple)
- Mild ductal hyperplasia
- Approximately 30% of total are classified as proliferative disease (PD) with relative cancer risk of 1.7 – 2.1 times:[5]
- Usual ductal hyperplasia
- Sclerosing adenosis
- Columnar hyperplasia
- Papilloma
- Radical scar
- Approximately 5% to 8% of the rest are regarded as PD with atypia and relative cancer risk more than 4 times:[6]
- Atypical lobar hyperplasia
- Lobular carcinoma in situ
- Atypical ductal hyperplasia
- Unclear risk
Classification of benign breast lesion according to histological region:[7]
- Terminal and lobular ducts
- Acinar distention
- Intralobular connective tissue proliferation
- Epithelial changes in terminal duct lobular units (TDLU)
- Apocrine metaplasia
- Ductal and lobular hyperplasia, usual and typical
- Papillomatosis
- Intracystic papilloma
- Ductal system
- Lesion of different origin
- Fatty tissue lesion
- Lipoma
- Liponecrosis
- Fibrous tissue lesions
- Vascular origin
- Inflammatory origin
- Mastitis/abscess
- Tuberculosis and sarcoidosis
- Foreign body granuloma and siliconoma
- Lymph node origin
- Fatty tissue lesion
References
References
- ↑ Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degnim AC, Ghosh K; et al. (2005). “Benign breast disease and the risk of breast cancer”. N Engl J Med. 353 (3): 229–37. doi:10.1056/NEJMoa044383. PMID 16034008.
- ↑ London SJ, Connolly JL, Schnitt SJ, Colditz GA (1992). “A prospective study of benign breast disease and the risk of breast cancer”. JAMA. 267 (7): 941–4. PMID 1734106.
- ↑ Dupont WD, Page DL (1985). “Risk factors for breast cancer in women with proliferative breast disease”. N Engl J Med. 312 (3): 146–51. doi:10.1056/NEJM198501173120303. PMID 3965932.
- ↑ Love SM, Gelman RS, Silen W (1982). “Sounding board. Fibrocystic “disease” of the breast–a nondisease?”. N Engl J Med. 307 (16): 1010–4. doi:10.1056/NEJM198210143071611. PMID 7110289.
- ↑ Dupont WD, Page DL (1985). “Risk factors for breast cancer in women with proliferative breast disease”. N Engl J Med. 312 (3): 146–51. doi:10.1056/NEJM198501173120303. PMID 3965932.
- ↑ Page DL, Dupont WD, Rogers LW, Landenberger M (1982). “Intraductal carcinoma of the breast: follow-up after biopsy only”. Cancer. 49 (4): 751–8. PMID 6275978.
- ↑ Lanyi, M (2003). Mammography : diagnosis and pathological analysis. Berlin New York: Springer-Verlag. ISBN 9783540441137.
- ↑ Lai EC, Chan WC, Ma TK, Tang AP, Poon CS, Leong HT (2005). “The role of conservative treatment in idiopathic granulomatous mastitis”. Breast J. 11 (6): 454–6. doi:10.1111/j.1075-122X.2005.00127.x. PMID 16297091.
- ↑ Kudva YC, Reynolds C, O’Brien T, Powell C, Oberg AL, Crotty TB (2002). ““Diabetic mastopathy,” or sclerosing lymphocytic lobulitis, is strongly associated with type 1 diabetes”. Diabetes Care. 25 (1): 121–6. PMID 11772912.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shadan Mehraban, M.D.[2]