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Bronchospasm

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Prashanth Saddala M.B.B.S.; Areej Tariq.

Overview

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Bronchospasm is a difficulty in breathing caused by a sudden constriction of the muscles in the walls of the bronchioles.

References

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Historical Perspective

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Classification

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Pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Pathophysiology

Bronchospasm is caused by the release (degranulation) of substances from mast cells or basophils under the influence of anaphylatoxins. The overactivity of the bronchioles’ muscle is a result of exposure to a stimulus which under normal circumstances would cause little or no response. The resulting constriction and inflammation causes a narrowing of the airways and an increase in mucus production; this reduces the amount of oxygen that is available to the individual causing breathlessness, coughing and hypoxia.

Inflamed airways and bronchoconstriction in asthma. Airways narrowed as a result of the inflammatory response cause wheezing.

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Causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Causes

Common Causes

Causes by Organ System

Cardiovascular Churg-Strauss syndrome, Anaphylactic shock
Chemical / poisoning 5-Hydroxyindoleacetic acid, Alanycarb, Aldicarb, Aldoxycarb, Allyxycarb, Amidithion, Aminocarb, Amiton, Anaphylatoxin, Athyl-Gusathion, Azinfosethyl, Azinfos-methyl, Azinophos-methyl, Azinphos, Azinphos-ethyl, Azinphos-methyl, Azinphosmetile, Azothoate, Aztreonam, Bendiocarb, Benfuracarb, Benoxafos, Bromophos, Bromophos-ethyl, Snake bite, Bufencarb, Butacarb, Butocarboxim, Butoxcarboxim, Cadusafos, Carbamates, Carbaryl, Carbofuran, Carbophenothion, Carbosulfan, Caterpillar poisoning, Chlorfenvinphos, Chlorine Dioxide, Chloroacetophenone, Chlorobenzylidene Malononitrile, Chloropyrifos, Chlorpyrifos methyl, Cloethocarb, CS gas, Cyanthoate, Decarbofuran, Demeton, Demeton-methyl, Demeton-O, Demeton-O-methyl, Demeton-S-methyl, Demeton-S-methylsulphon, Dialifos, Diazinon, Dichlorvos, Dicresyl, Dicrotophos, Dimetan, Dimethoate, Dimetilan, Dioxacarb, Dioxathion, Disulfoton, EMPC, Endothion, Ethiofencarb, Ethion, Ethoate-methyl, Ethoprophos, Ethyl-guthion, Etrimfos, Eucalyptus oil , Fenchlorphos, Fenethacarb, Fenitrothion, Fenobucarb, Fensulfothion, Fenthion, Fonophos, Formothion, Furathiocarb, Gonionemus poisoning, Guthion (ethyl), Heptenophos, Hydrogen sulfide, Hyquincarb, Iodofenphos, Isofenphos, Isoprocarb, Latex allergy, Malathion, Mecarbam, Methacrifos, Methamidophos, Methidathion, Methiocarb, Methomyl, Methylene Diisocyanate, Metiltriazotion, Metolcarb, Mevinphos, Mexacarbate, Minocycline hydrochloride, Monocrotophos, Monosodium glutamate, Nitrilacarb, Nitrogen dioxide, Nitromethane, Omethoate, Organophosphates, Oxacillin, Oxamyl, Oxydeprofos, Oxydisulfoton, Parathion, Parathion Methyl, Phenkapton, Phorate, Phosalone, Phosdrin, Phosmet, Phosphamidon, Phoxim, Pirimicarb, Pirimiphos-methyl, Platinum salts, Primiphos methyl, Profenofos, Promacyl, Promecarb, Propoxur, Prothidathion, Prothoate, Pyrimitate, Quinalphos, Quintiofos, Radiocontrast, Scombroid, Smoke inhalation, Sophamide, Sulfotep, Sulfur Trioxide, Tazimcarb, Terbufos, Tetraethyl Pyrophosphate, Tetrodotoxin, Thiocarboxime, Thiodicarb, Thiofanox, Thiometon, Tolclofos methyl, Toluene Diisocyanate, Triazophos, Triazotion, Trifenfos, Trimethacarb, Vamidothion, XMC, Xylylcarb, Analgesic asthma syndrome
Dermatologic No underlying causes
Drug Side Effect Abciximab, acetylcysteine, acetylsalicylic acid, adenosine, alemtuzumab, aspirin, atenolol, atovaquone, atracurium, beclometasone dipropionate, benzonatate, beta-blockers, betahistine, betaxolol, bethanechol, caspofungin acetate, cocaine, colistin, cyclizine, cytomegalovirus immune globulin, decongestants, diclofenac, docetaxel, felbinac, hydroxyethyl starch, ibritumomab tiuxetan, Ibuprofen, Indometacin, Interferon gamma, Ixabepilone, Ketamine, Ketorolac, Labetalol, Levobunolol hydrochloride,Nadolol, Naproxen and esomeprazole magnesium, nitrazepam, nSAIDs, omalizumab, olsalazine, oxymetazoline, panitumumab, pegaspargase, penicillin, pentamidine isethionate, phenylephrine, pilocarpine, propafenone, propranolol, ramucirumab, rapacuronium, ritonavir, sertraline, sipuleucel-T, streptokinase, teniposide, timolol, umeclidinium, zanamivir
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental Byssinosis, Pollen allergy
Gastroenterologic No underlying causes
Genetic No underlying causes
Hematologic Hypereosinophilic syndrome, Mastocytosis
Iatrogenic Blood transfusion, Bronchial challenge test, Exercise stress testing
Infectious Disease Pfiesteria piscicida , Pneumonia, Schistosomiasis, Pulmonary eosinophilia, Pulmonary strongyloidiasis, Viral illness, Visceral larva migrans, Allergic bronchopulmonary aspergillosis, Bronchiolitis, LRTI, URTI, Giardiasis
Musculoskeletal / Ortho No underlying causes
Neurologic No underlying causes
Nutritional / Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic Carcinoid tumour
Opthalmologic No underlying causes
Overdose / Toxicity Abciximab, Acetylcysteine, Acetylsalicylic acid, Adenosine, Alemtuzumab, Aspirin, Atenolol, Atracurium, Benzonatate, Beta-blockers, Betahistine, Betaxolol, Bethanechol, Cocaine, Colistin, Cyclizine, Diclofenac, Felbinac, Hydroxyethyl starch, Ibritumomab tiuxetan, Ibuprofen, Indometacin, Ketamine, Ketorolac, Labetalol, Nadolol, Nitrazepam, NSAIDs, Penicillin, Pentamidine, Pilocarpine, Propafenone, Propranolol, Rapacuronium, Streptokinase, Timolol, Zanamivir, Decongestants, Oxymetazoline, Phenylephrine
Psychiatric No underlying causes
Pulmonary Shaver’s disease, Allergic bronchopulmonary aspergillosis, Asthma, Bronchiolitis, Bronchopulmonary dysplasia, Emphysema, Churg-Strauss syndrome, Analgesic asthma syndrome, Pneumonia, Pulmonary strongyloidiasis, Aspiration, Byssinosis, COPD, LRTI, URTI
Renal / Electrolyte No underlying causes
Rheum / Immune / Allergy Anaphylaxis, Food allergy, Peanut allergy, Pollen allergy, Latex allergy, Anaphylactic shock
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Dental No underlying causes
Miscellaneous Anaphylaxis, Anaphylactic shock, Aspiration, Exercise induced bronchospasm, Food allergy, Clove cigarette smoking, Near-drowning, Peanut allergies, Carcinoid syndrome, Snake bite, Latex allergy, Pollen allergy, Cocaine

Causes in Alphabetical Order


References

  1. Marsh, Alex; Gordon, David; Heslop, Pauline; Pantazis, Christina (2000). “Housing Deprivation and Health: A Longitudinal Analysis”. Housing Studies. 15 (3): 411. doi:10.1080/02673030050009258.

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Differentiating Bronchospasm from other Diseases

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Epidemiology and Demographics

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Risk Factors

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Natural History, Complications and Prognosis

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Diagnosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Chest X Ray | CT | MRI | Other Imaging Findings | Other Diagnostic Studies

Treatment

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case Studies

Case#1


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