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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Congenital rubella syndrome CDC case definitions

Introduction

Overview

Overview

In 2009, the CDC published the case classification of congenital rubella syndrome and divided into suspected cases, probable cases, confirmed cases and infection only, based on symptoms and/or laboratory findings.[1]

CDC Case Definitions

CDC Case Definitions

in 2009, the CDC published the following case definition for case classification of congenital rubella syndrome:[1]

Case Classification Criteria
Suspected An infant who does not meet the criteria for a probable or confirmed case but who has one or more of the following findings:
Probable An infant who does not have laboratory confirmation of rubella infection but has at least two of the following, without a more plausible etiology:

OR

An infant who does not have laboratory confirmation of rubella infection but has at least one or more of the following, without a more plausible etiology:

AND

One or more of the following:

Confirmed An infant with at least one of the symptoms clinically consistent with congenital rubella syndrome listed above; and laboratory evidence of congenital rubella infection demonstrated by:
  1. Isolation of rubella virus, OR
  2. Detection of rubella-specific immunoglobulin M (IgM) antibody, OR
  3. Infant rubella antibody level that persists at a higher level and for a longer period of time than expected from passive transfer of maternal antibody (i.e., rubella titer that does not drop at the expected rate of a two-fold decline per month), OR
  4. A specimen that is PCR-positive for rubella virus
Infection only An infant without any clinical symptoms or signs of rubella but with laboratory evidence of infection demonstrated by:
References

References

  1. ↑ 1.0 1.1 Center for Disease Control and Prevention https://www.cdc.gov/vaccines/pubs/surv-manual/chpt15-crs.html. Accessed on Jan 5, 2017

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2], Dima Nimri, M.D. [3]