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Diphyllobothriasis medical therapy
Introduction
Overview
Overview
Medical therapy is the primary modality of treatment for diphyllobothriasis. Drugs used for diphyllobothriasis include either praziquantel or niclosamide.
Medical Therapy
Medical Therapy
The medications used in the treatment of diphyllobothriasis are:[1][2]
Antimicrobial Regimen
The dose for empiric treatment of diphyllobothriasis is as follows:[1][2]
- Diphyllobothriasis
- 1.1 Adult
- Preferred regimen (1): Praziquantel 5-10 mg/kg orally in a single-dose therapy.
- Alternative regimen (1): Niclosamide 2 gm single dose orally for adults.
- 1.2 Children
- Preferred regimen (1): Praziquantel 5-10 mg/kg orally in a single-dose therapy.
- Alternative regimen (1): Niclosamide 50 mg/kg (max 2 gm) orally once.
- 1.1 Adult
Mechanism of action
- Praziquantel
- Oral praziquantel is available for human use in the United States. Praziquantel increases the permeability of the cell membrane towards calcium ions. This induces contraction of the parasites, resulting in paralysis in the contracted state.
- Niclosamide
- Niclosamide inhibits the oxidative phosphorylation and anaerobic metabolism in the parasites.
References
References
- ↑ 1.0 1.1 “CDC – DPDx – Diphyllobothriasis”.
- ↑ 2.0 2.1 Scholz T, Garcia HH, Kuchta R, Wicht B (2009). “Update on the human broad tapeworm (genus diphyllobothrium), including clinical relevance”. Clin. Microbiol. Rev. 22 (1): 146–60, Table of Contents. doi:10.1128/CMR.00033-08. PMC 2620636. PMID 19136438.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2], Furqan M M. M.B.B.S[3]