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Glanzmann's thrombasthenia causes

Introduction

Overview

Overview

Glanzmann’s thrombasthenia can be inherited in an autosomal recessive manner or acquired as an autoimmune disorder. In the hereditary type of Glanzmann’s thrombasthenia GPIIb/IIIa (ITG αIIbβ3) is qualitative or quantitative disorder. The autoantibodies production is the main cause of acquired Glanzmann’s thrombasthenia It can be produced in the Acute lymphoblastic leukemia, Non-Hodgkin lymphoma, Multiple myeloma, Hairy cell leukemia, Myelodysplastic syndrome, Immune thrombocytopenic purpura (ITP), Pregnancy, Autoimmune diseases (eg, systemic lupus erythematosus, Immune thrombocytopenia),Anti-thrombotic drugs use , like abciximab, eptifibatide, and tirofiban which all antagonize αIIbβ3 and Platelet transfusions.

Causes

Causes

In the hereditary type of Glanzmann’s thrombasthenia GPIIb/IIIa (ITG αIIbβ3) is qualitative or quantitative disorder. The autoantibodies production is the main cause of acquired Glanzmann’s thrombasthenia It can be produced in the of following conditions:[1][2][3]

References

References

  1. ↑ Bierling P, Fromont P, Elbez A, Duedari N, Kieffer N (1988). “Early immunization against platelet glycoprotein IIIa in a newborn Glanzmann type I patient”. Vox Sang. 55 (2): 109–13. PMID 3055677.
  2. ↑ McMillan R (March 2005). “The role of antiplatelet autoantibody assays in the diagnosis of immune thrombocytopenic purpura”. Curr. Hematol. Rep. 4 (2): 160–5. PMID 15720967.
  3. ↑ Tholouli E, Hay CR, O’Gorman P, Makris M (October 2004). “Acquired Glanzmann’s thrombasthenia without thrombocytopenia: a severe acquired autoimmune bleeding disorder”. Br. J. Haematol. 127 (2): 209–13. doi:10.1111/j.1365-2141.2004.05173.x. PMID 15461628.
  4. ↑ Granel B, Swiader L, Veit V, Rey J, Reviron D, Disdier P, Harlé JR, Weiller PJ (November 1998). “[Pseudo-Glanzmann thrombasthenia in the course of autoimmune thrombocytopenic purpura]”. Rev Med Interne (in French). 19 (11): 823–5. PMID 9864781.
  5. ↑ Peaceman AM, Katz AR, Laville M (March 1989). “Bernard-Soulier syndrome complicating pregnancy: a case report”. Obstet Gynecol. 73 (3 Pt 2): 457–9. PMID 2915873.
  6. ↑ Blickstein D, Dardik R, Rosenthal E, Lahav J, Molad Y, Inbal A (2014). “Acquired thrombasthenia due to inhibitory effect of glycoprotein IIbIIIa autoantibodies”. Isr Med Assoc J. 16 (5): 307–10. PMID 24979837.
  7. ↑ Yee NS, Schuster SJ (April 2006). “Clinical remission of acquired thrombasthenia with low-dose methotrexate in a patient with systemic lupus erythematosus”. Mayo Clin. Proc. 81 (4): 566–7. doi:10.4065/81.4.566-a. PMID 16610580.
  8. ↑ Meyer M, Kirchmaier CM, Schirmer A, Spangenberg P, Ströhl C, Breddin K (May 1991). “Acquired disorder of platelet function associated with autoantibodies against membrane glycoprotein IIb-IIIa complex–1. Glycoprotein analysis”. Thromb. Haemost. 65 (5): 491–6. PMID 1871709.
  9. ↑ Solh T, Botsford A, Solh M (2015). “Glanzmann’s thrombasthenia: pathogenesis, diagnosis, and current and emerging treatment options”. J Blood Med. 6: 219–27. doi:10.2147/JBM.S71319. PMC 4501245. PMID 26185478.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2], Niyousha Danesh, MD-MPH