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Lopinavir ritonavir
Introduction
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Overview
Overview
Lopinavir/ritonavir (INNs) is a fixed dose combination drug for the treatment of HIV infection. It combines lopinavir (not available as a single drug) with a sub-therapeutic dose of ritonavir (trade name Norvir) into a fixed-dose pill.
The combination is marketed by Abbott as Kaletra (high-income countries) and Aluvia (low-income countries), as a component of combination therapy to treat HIV/AIDS. The Kaletra formulation has also been used successfully as monotherapy in some studies.[1]
As of 2006, lopinavir/ritonavir forms part of the preferred combination for first-line therapy recommended by the United States Department of Health and Human Services (DHHS).[2] It is available as capsules, tablets and oral solution.
Category
Category
Antiretroviral
US Brand Names
US Brand Names
KALETRA®
FDA Package Insert
FDA Package Insert
Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Overdosage | Dosage and Administration | How Supplied | Labels and Packages
Mechanism of Action
Mechanism of Action
Lopinavir is an antiviral drug. As co-formulated in KALETRA, ritonavir inhibits the CYP3A-mediated metabolism of lopinavir, thereby providing increased plasma levels of lopinavir.[3]
References
References
- ↑ Gadd, Christopher; Alcorn, Keith (18 August 2006). “Kaletra monotherapy as effective as triple therapy for at least 18 months”. aidsmap.com. aidsmap. Retrieved 24 June 2011.
- ↑ DHHS panel. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents (May 4, 2006). (Available for download from AIDSInfo)
- ↑ “KALETRA (LOPINAVIR AND RITONAVIR) TABLET, FILM COATED KALETRA (LOPINAVIR AND RITONAVIR) SOLUTION [ABBVIE INC.]”. Text ” accessdate” ignored (help)
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]