Mesothelioma other diagnostic studies
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Overview
Other diagnostic studies for mesothelioma include laparoscopy, thoracoscopy, pleuroscopy, biopsy, position emission tomography scan, and fluorescence in situ hybridization.
Other Diagnostic Studies
Other Diagnostic Studies
Laparoscopy, Thoracoscopy, and Pleuroscopy
- Thoracoscopy or pleuroscopy may help in the diagnosis of mesothelioma.[1][2][3][4][1]
- Laparoscopy may be used to diagnose and treat selected cases of well-differentiated papillary mesothelioma associated with pelvic endometriosis.[5]
Biopsy
- Biopsy is helpful in the diagnosis of mesothelioma.[2]
- Procedures performed for biopsy may include:[2]
Position Emission Tomography
- Positron emission tomography is becoming useful in two clinical settings:[3]
- In addition, there appears to be a correlation between the degree of FDG uptake and the biological aggressiveness of the tumor, which may help to guide treatment.[3]
Fluorescence In Situ Hybridization (FISH)
- FISH may be helpful in the diagnosis of mesothelioma. It helps in distinguishing malignant mesothelioma from reactive mesothelial cells in effusions.[4]
- Mutlitarget FISH assay may be used to detect chromosomal abberations (chromosomes 3, 7, 17, and 9p21).
- FISH technique may also be used to explore the alternative mechanism of tumor suppressor gene inactivation by methylation of p16, p14, and p15 gene in the pathogenesis of mesothelioma.[4]
References
References
- ↑ 1.0 1.1 Alvarez JM, Hasani A, Segal A, Sterret G, Millward M, Nowak A; et al. (2009). “Bilateral thoracoscopy, mediastinoscopy and laparoscopy, in addition to CT, MRI and PET imaging, are essential to correctly stage and treat patients with mesothelioma prior to trimodality therapy”. ANZ J Surg. 79 (10): 734–8. doi:10.1111/j.1445-2197.2009.05060.x. PMID 19878170.
- ↑ 2.0 2.1 2.2 Tests that examine the inside of the chest and abdomen are used to detect (find) and diagnose malignant mesothelioma. National cancer institute 2016. http://www.cancer.gov/types/mesothelioma/patient/mesothelioma-treatment-pdq. Accessed on February 15, 2016
- ↑ 3.0 3.1 3.2 Radiographic findings of mesothelioma. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/mesothelioma. Accessed on February 8, 2015
- ↑ 4.0 4.1 4.2 Savic S, Franco N, Grilli B, Barascud Ade V, Herzog M, Bode B; et al. (2010). “Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology”. Chest. 138 (1): 137–44. doi:10.1378/chest.09-1951. PMID 20139227.
- ↑ Nezhat FR, DeNoble SM, Brown DN, Shamshirsaz A, Hoehn D (2010). “Laparoscopic management of peritoneal mesothelioma associated with pelvic endometriosis”. J Minim Invasive Gynecol. 17 (5): 646–50. doi:10.1016/j.jmig.2010.03.025. PMID 20728825.
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