Mitral valve prolapse causes
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Farman Khan, MD, MRCP [2]
Overview
Overview
Mitral valve prolapse (MVP) is a valvular heart disease that is considered to be mainly hereditary. Myxomatous degeneration of the mitral valve is a common cause of MVP. Other less common causes of MVP include connective tissue diseases such as Marfan’s syndrome, Ehlers Danlos syndrome and osteogenesis imperfecta, as well as damage to the mitral valve secondary to infarction, rheumatic heart disease, hypertrophic cardiomyopathy and trauma.
Causes
Causes
Common Causes
- Marfan’s syndrome
- Myxomatous degeneration of the mitral valve
- Papillary muscle infarction
- Papillary muscle trauma
Causes by Organ System
| Cardiovascular | myxomatous of the mitral valve, myocardial infarction, severe mitral annular calcification, damaged chordae tendineae, rheumatic heart disease, papillary muscle dysfunction, hypertrophic cardiomyopathy, forme fruste Barlow disease, Ebstein’s anomaly , cardiomegaly, bacterial endocarditis, congenital heart disease |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | No underlying causes |
| Ear Nose Throat | No underlying causes |
| Endocrine | Graves disease |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | Turner Syndrome, spastic ataxia, Charlevoix-Saguenay type, osteogenesis imperfecta, X-linked familial mitral valve prolapse, autosomal dominant familial mitral valve prolapse, MASS phenotype, Marfan syndrome, Marfan-like syndrome Boileau type, Hunter-Mcdonald syndrome, Furlong-Kurczynski-Hennessy syndrome |
| Hematologic | Von Willebrand disease, sickle cell disease |
| Iatrogenic | No underlying causes |
| Infectious Disease | Infective endocarditis, acute rheumatic fever |
| Musculoskeletal/Orthopedic | Dermato-cardio-skeletal syndrome Borrone type |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | Scurvy |
| Obstetric/Gynecologic | Pregnancy |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | Polycystic kidney disease |
| Rheumatology/Immunology/Allergy | SLE, pseudoxanthoma elasticum, polyarteritis nodosa, connective tissue disease, mixed connective tissue disease, Ehlers-Danlos syndrome type I, Ehlers-Danlos syndrome type II, Ehlers-Danlos syndrome Type V |
| Sexual | No underlying causes |
| Trauma | Trauma to mitral valve |
| Urologic | No underlying causes |
| Miscellaneous | Stickler Syndrome, Leopard syndrome, idiopathic, fibroelastic deficiency, Dahlberg syndrome, Beals syndrome |
Causes in Alphabetical Order
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