Primary sclerosing cholangitis laboratory findings

The workup in patients with primary sclerosing cholangitis consists of LFTs, serum immunoglobulins, as well as a number of autoantibodies. Patients with primary sclerosing cholangitis typically have an elevated level of ALP, amongst other findings. However, laboratory results in many patients may be normal.

The workup in patients with primary sclerosing cholangitis consists of LFTs, serum immunoglobulins, as well as a number of autoantibodies. Patients with primary sclerosing cholangitis typically have an elevated level of ALP, amongst other findings. However, laboratory results in many patients may be normal.^{[1][2][3][4][5][6]}

Primary sclerosing cholangitis typically has a cholestatic clinical picture with elevation of ALP, and aminotransferases (AST and ALT) may be elevated to 2-3 times of the upper normal level. However, LFTs may be normal.

• Hypergammaglobulinemia
• Elevated IgM levels
• Elevated IgG4 levels

One or more of the following autoantibodies may be present in patients with primary sclerosing cholangitis:

• Anti-neutrophil cytoplasmic antibody (p-ANCA)
• Anti-nuclear antibody (ANA)
• Anti-smooth muscle antibody (Anti-Sm)
• Anti-endothelial antibody
• Anti-cardiolipin antibody
• Thyroperoxidase
• Thyroglobulin
• Rheumatoid factor (RF)

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