Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Pseudohypoparathyroidism laboratory findings
Introduction
Overview
Overview
The diagnosis of pseudohypoparathyroidism is made by measurement of variations in serum calcium, phosphorus, cAMP and calcitriol and in urinary cAMP and phosphorus excretion helps in assessment of skeletal and renal responsiveness to parathyroid hormone.
Laboratory Findings
Laboratory Findings
- The diagnosis of pseudohypoparathyroidism is made by measurement of variations in serum calcium, phosphorus, cAMP and calcitriol and in urinary cAMP and phosphorus excretion helps in assessment of skeletal and renal responsiveness to parathyroid hormone [1]
- Laboratory findings consistent with the diagnosis of pseudohypoparathyroidism include
- Hypocalcemia
- Hyperphosphatemia
- Elevated serum concentration of parathyroid hormone
- Diminished urinary cAMP response after administration of the biosynthetic N-terminal fragment of parathyroid hormone
- Secondary hyperparathyroidism and hyperparathyroid bone disease due to the parathyroid hormone resistance
- Immunoradiometric assay (IRMA) can be used to measure serum parathyroid hormone concentration
- Assessment of thyroid function tests, gonadotropin, testosterone, estrogen and insulin like growth factor will help in identification of any associated underlying hormonal dysfunction
References
References
- ↑ Shalitin S, Davidovits M, Lazar L, Weintrob N (2008). “Clinical heterogeneity of pseudohypoparathyroidism: from hyper- to hypocalcemia”. Horm. Res. 70 (3): 137–44. doi:10.1159/000137658. PMID 18663313.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mazia Fatima, MBBS [2]