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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Pubertal Delay

Introduction

Overview

Overview

Delayed onset of puberty is considered 14 years old in girls and 15 years old in boys. Most frequently, the delay is due to a constitutional, non-pathologic delay in growth and puberty.

Causes

Causes

Common Causes[1] [2]

Causes by Organ System

Cardiovascular Cardiac conditions, Cyanotic congenital heart disease, Vascular lesions
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic Alopecia, Ectodermal dysplasia, Mumps orchitis, Mumps
Drug Side Effect Anabolic steroids, Cytotoxic drugs
Ear Nose Throat No underlying causes
Endocrine Addison’s disease, Adrenal failure, Adrenal hypoplasia congenital, Combined pituitary hormone deficiency, Congenital adrenal hyperplasia, Congenital hypopituitarism, Congenital hypothyroidism , Constitutional delay , Cushing syndrome, Excess thyroid hormone consumption, Forbes disease , Froelich’s syndrome , Growth hormone deficiency, Hydrocephalus obesity hypogonadism , Hyperthyroidism, Hypogonadism, Hypogonadotrophic hypogonadism, Hypopituitarism, Hypothalamic cyst, Hypothalamic damage, Hypothalamic dysfunction , Hypothalamic infection, Hypothalamus disease, Hypothyroidism, Infantile hypothyroidism , Laron pituitary dwarfism , Laron syndrome , Low body weight, Luteinizing hormone deficiency, Lyndi’s syndrome, Multiple tropic hormone deficiency, Neuroectodermal endocrine syndrome , Niemann-pick disease , Panhypopituitarism , Pituitary adenoma, Pituitary gland abscess, Pituitary gland cyst, Pituitary gland damage, Pituitary gland infection, Pituitary gland tumor, Salti-salem syndrome, Spastic paraplegia with kallmann syndrome, Thyroid agenesis , Underactive thyroid gland, Woodhouse sakati syndrome 
Environmental No underlying causes
Gastroenterologic Celiac disease, Celiac sprue, Collagenous celiac disease , Crohn’s disease, Gluten enteropathy, Glycogen debranching deficiency , Inflammatory bowel disease, Tricho-hepato-enteric syndrome , Type iii glycogen storage disease
Genetic Anorchism, Bangstad syndrome , Bassoe syndrome , Beta thalassemia , Biedl-bardet syndrome, Bird-headed dwarfism , Bosma-henkin-christiansen syndrome , Bullous dystrophy, Camurat-engelmann disease, Cantu sanchez-corona fragoso syndrome , Chromophobe adenoma, Chromosome 13 ring syndrome , Chromosome 14 uniparental disomy syndrome , Chromosome 3, monosomy 3p2, Chromosome 9, trisomy 9p , Cockayne syndrome type 1, Cohen syndrome , Crandall syndrome , Craniopharyngioma, Eunuchoidism familial, Fabry disease, Familial dysautonomia , Fleisher syndrome , Fshb mutation, Haspeslagh fryns muelenaere syndrome , Image syndrome , Kallmann’s syndrome, Kleinfelter’s syndrome, Lack of gonadotrophin-releasing hormone, Laurence-moon-biedl syndrome, Malouf syndrome , Mandibuloacral dysplasia , Marinesco-sjogren syndrome , Noonan’s syndrome, Prader-willi syndrome, Prenatal dwarfism , Richards-rundle syndrome, Schaap-taylor-baraitser syndrome , Schofer beetz bohl syndrome , Sengers-hamel-otten syndrome , Shprintzen-golberg craniosynostosis , Singh-chhaparwal-dhanda syndrome, Sohval-soffer syndrome , Spastic paraplegia with kallmann syndrome, Turner’s syndrome, Woodhouse sakati syndrome 
Hematologic Alpha thalassemia, Anemia, Beta thalassemia , Chondrodysplasia punctata with steroid sulfatase deficiency , Congenital spherocytic hemolytic anemia , Diamond-blackfan anemia , Hyperprolactinemia, Insulin-resistance syndrome, Isolated gonadotropin deficiency, Lymphangiectasies , Lymphoedema , Malabsorption syndrome, Prolactinoma, Pure red cell aplasia, Sickle cell anemia , Somatotropin deficiency, Type 1 diabetes , Type iii glycogen storage disease
Iatrogenic Iatrogenic, Radiation therapy, X-irradiation
Infectious Disease Chronic infection, Hypothalamic infection, Infections, Mumps orchitis, Mumps, Persistent major infection, Pituitary gland abscess, Pituitary gland cyst, Pituitary gland infection, Tuberculosis
Musculoskeletal/Orthopedic Ataxia, Cystic fibrosis, Fibromatosis multiple non ossifying , Metaphyseal undermodeling, Myopathy , Spinocerebellar ataxia
Neurologic Biemond syndrome type 2 , Bosma-henkin-christiansen syndrome , Cantu sanchez-corona fragoso syndrome , Central nervous system tumours, Craniopharyngioma, Deafness neurosensory, Familial dysautonomia , Froelich’s syndrome , Hall-riggs mental retardation syndrome, Hersh-podruch-weisskopk syndrome, Meningioma, Mental retardation, Microcephaly , William’s syndrome
Nutritional/Metabolic Celiac disease, Celiac sprue, Chronic metabolic disorder, Collagenous celiac disease , Fabry disease, Insulin-resistance syndrome, Kwashiorkor , Malabsorption syndrome, Malnutrition, Niemann-pick disease , Type 1 diabetes , Zinc deficiency 
Obstetric/Gynecologic Autoimmune ovarian failure , Female reproductive toxicity , Intrauterine growth retardation, Müllerian agenesis, Ovarian cysts, Ovarian dysgenesis, Ovarian torsion, Prenatal dwarfism , Serious ovarian infection, Serious testicular infection, Ulnar-mammary syndrome of pallister
Oncologic Chemotherapy, Germinoma, Glioma, Malignancy, Masculinizing tumor of ovary, Meningioma, Optic chiasma glioma, Pituitary adenoma, Pituitary gland tumor, Prolactinoma
Ophthalmologic Anophthalmia , Optic chiasma glioma, Pterygia , Resistant ovary syndrome, Retinitis pigmentosa
Overdose/Toxicity Female reproductive toxicity 
Psychiatric Anorexia nervosa, Bulimia nervosa, Serious emotional stress
Pulmonary Tuberculosis
Renal/Electrolyte Chronic renal failure
Rheumatology/Immunology/Allergy Autoimmune disease, Autoimmune ovarian failure , Autoimmune thyroid disease , Connective-tissue diseases, Cystic fibrosis, Fibromatosis multiple non ossifying , Gluten enteropathy, Granulomas, Juvenile arthritis, Refractory celiac disease 
Sexual No underlying causes
Trauma Castration, Excessive exercise, Head trauma, Heavy physical excercise, Pituitary gland damage, Trauma
Urologic Adiposogenital dystrophy, Anorchism, Castration, Cataract deafness hypogonadism , Frasier syndrome, Germinoma, Gonadal dysgenesis epibulbar dermoid, Gonadotropin deficiency, Ichthyosis male hypogonadism , Mixed gonadal dysgenesis, Primary gonadal failure, Pure dysgenesis, Torsion of the testis, Undescended testes
Miscellaneous Chronic illness

Causes in Alphabetical Order

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Template:WikiDoc Sources

  1. ↑ Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
  2. ↑ Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S.