Respiratory acidosis causes

Common causes of respiratory acidosis include chronic obstructive pulmonary disease (COPD), Neuromuscular diseases, Chest wall disorders, obesity–hypoventilation syndrome, Obstructive sleep apnea (OSA), the Central nervous system (CNS) depression, lung and airway diseases etc.

Respiratory acidosis may be caused by:

• Patients suffering from COPD conditions like Emphysema, chronic bronchitis, asthma.^[1][2][3][4]
• Chest wall disorders like amyotrophic lateral sclerosis (ALS), Paralysis and dysfunction of diaphragm, Guillain-Barré syndrome(Ascending paralysis), Myasthenia gravis(Acetylcholine receptor antibodies), Muscular dystrophy, Botulism(food poisoning caused by a bacterium)
• Obesity–hypoventilation syndrome: A condition which is seen most commonly in which severely overweight people who fail to breathe deeply enough, which results in low blood oxygen levels and high blood carbon dioxide (CO₂) levels.^[5][6]
• Obstructive sleep apnea (OSA): OSA frequency increases with age and obesity. In this condition, breath can become very shallow or one may even stop breathing.^[7]
• Central nervous system (CNS) depression:
  • Drugs: Drugs like narcotics, barbiturates, benzodiazepines which depress the central respiratory system.
  • Neurologic disorders: like trauma, brainstem disease, and encephalitis.
  • Primary alveolar hypoventilation: Its a disorder in which it results in respiratory arrest during sleep.
  • Congenital central alveolar hypoventilation syndrome: It is rare but lifelong and life-threatening disorder. It affects both central and autonomic nervous system which controls heart rate, blood pressure, sensing of oxygen and carbon dioxide levels in the blood, temperature etc.Congenital central alveolar hypoventilation syndrome is also called as Ondine curse.

Less Common Causes

Less common causes of disease name include:

• Laryngeal and tracheal stenosis
• Interstitial lung disease

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