Tumor necrosis factor receptor

Overview

A tumor necrosis factor receptor (TNFR) is, as its name would indicate, a receptor which binds tumor necrosis factors (TNF).

Because “TNF” is often used to describe TNF alpha, “TNFR” is often used to describe the receptors that bind to TNF alpha – namely, CD120. However, there several other members of this family that bind to the other TNFs.^[1]^[2]

Members

Family members include:^[1]

type 1
- CD120 – TNFRSF1A
- TNFRSF1B
type 3
- Lymphotoxin beta receptor – LTBR
type 4
- CD134 – TNFRSF4
type 5
- CD40 – CD40
type 6
- FAS – FAS
- TNFRSF6B
type 7
- CD27 – CD27
type 8
- CD30 – TNFRSF8
type 9
- CD137 – TNFRSF9
type 10
- TNFRSF10A – TNFRSF10A
- TNFRSF10B – TNFRSF10B
- TNFRSF10C
- TNFRSF10D
type 11
- RANK – TNFRSF11A
- Osteoprotegerin – TNFRSF11B
type 12
- TNFRSF12A
type 13
- TNFRSF13B
- TNFRSF13C
type 14
- TNFRSF14
type 16
- Nerve growth factor receptor – NGFR
type 17
- TNFRSF17
type 18
- TNFRSF18
type 19
- TNFRSF19
- RETL
type 21
- TNFRSF21
type 25
- TNFRSF25

References

↑ ^1.0 ^1.1 Locksley RM, Killeen N, Lenardo MJ (2001). “The TNF and TNF receptor superfamilies: integrating mammalian biology”. Cell. 104 (4): 487–501. doi:10.1016/S0092-8674(01)00237-9. PMID 11239407.
↑ Hehlgans T, Pfeffer K (2005). “The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games”. Immunology. 115 (1): 1–20. doi:10.1111/j.1365-2567.2005.02143.x. PMID 15819693.

External links

Tumor+Necrosis+Factor+Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

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[pmid11239407-1] 1.0 ^1.1 Locksley RM, Killeen N, Lenardo MJ (2001). “The TNF and TNF receptor superfamilies: integrating mammalian biology”. Cell. 104 (4): 487–501. doi:10.1016/S0092-8674(01)00237-9. PMID 11239407.

[pmid15819693-2] Hehlgans T, Pfeffer K (2005). “The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games”. Immunology. 115 (1): 1–20. doi:10.1111/j.1365-2567.2005.02143.x. PMID 15819693.

[1]

[2]

Tumor necrosis factor receptor

Overview

Members

References

External links

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