Von Willebrand disease causes

VWD is caused by a quantitative or qualitative defect in vWF. Most cases of vWD are due to inherited mutations that affect production of vWF. There are also acquired forms of vWD where vWF is impaired due to other pathological processes. Acquired defects in vWF can be caused by a number of conditions,for example mitral valve prolapse, ventricular assist device, ventricular septal defect, aortic stenosis, monoclonal gammopathy of undetermined significance, chronic myeloid leukemia and chronic lymphocytic leukemia, wilms tumor, waldenström macroglobulinemia, essential thrombocythemia, multiple myeloma, non-Hodgkin lymphoma, polycythemia vera, valproic acid, ciprofloxacin, griseofulvin, systemic lupus erythematosus,hypothyroidism, uremia, hemoglobinopathies and angiodysplasia.

• There are no life-threatening causes of von willebrand disease.

Common causes of von willebrand disease may include:^[1][2]

• Chronic myeloid leukemia
• Chronic lymphocytic leukemia
• Wilms tumor
• Essential thrombocythemia
• Non-Hodgkin lymphoma
• Mitral valve prolapse
• Ventricular assist device
• Ventricular septal defect
• Aortic stenosis
• Valproic acid
• Ciprofloxacin

Less common causes of von Willebrand disease include:^[3]

• Waldenström macroglobulinemia
• Multiple myeloma
• Polycythemia vera
• Wilms tumor
• Systemic lupus erythematosus
• Hypothyroidism
• Uremia
• Hemoglobinopathies
• Angiodysplasia

• The vWF gene is located on the short arm p of chromosome 12 (12p13.2) von Willebrand disease is caused by a mutation in this gene.

List the causes of the disease in alphabetical order: