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Hypothermia

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]

Overview

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Hypothermia is a condition in which an organism’s temperature drops below that required for normal metabolism and bodily functions. In warm-blooded animals, core body temperature is maintained near a constant level through biologic homeostasis. But when the body is exposed to cold its internal mechanisms may be unable to replenish the heat that is being lost to the organism’s surroundings.

Differentiating Hypothermia from other Diseases

Hypothermia is the opposite of hyperthermia. Because the words sound alike, they are easily confused.

Treatment

Surgery

Profound hypothermia can be an indication to be placed on extracorporeal circulation (bypass pump).

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Historical Perspective

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Pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Pathophysiology

  • Normal body temperature in humans is 37°C (98.6°F). Hypothermia can be divided into three stages of severity.
  • In stage 1, body temperature drops by 1-2°C below normal temperature (1.8-3.6°F). Mild to strong shivering occurs. Blood vessels in the outer extremities constrict, lessening heat loss to the outside air. Breathing becomes quick and shallow. Goose bumps form, raising body hair on end in an attempt to create an insulating layer of air around the body (this is of limited use in humans due to lack of sufficient hair, but it can be useful in other species). Often, a person will experience a warm sensation, as if they have recovered, but they are in fact heading into Stage 2. Another test to see if the person is entering stage 2 is if they are unable to touch their thumb with their little finger; this is the first stage of poor muscle coordinaton.
  • In stage 2, body temperature drops by 2-4°C (3.6-7.2°F). Shivering becomes more violent. Muscle mis-coordination becomes apparent. Movements are slow and labored, accompanied by a stumbling pace and mild confusion, although the victim may appear alert. Surface blood vessels contract further as the body focuses its remaining resources on keeping the vital organs warm.
  • In stage 3, body temperature drops below approximately 32°C (90°F). Shivering usually stops. Cellular metabolic processes shut down. Major organs fail. Clinical death occurs. Because of decreased cellular activity in stage 3 hypothermia, the body will actually take longer to undergo brain death.

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Causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Causes

Common Causes

Causes by Organ System

Cardiovascular Asystole, Atrioventricular Block, Cardiac arrest, Hypotension, Pulseless electrical activity, Pulseless ventricular tachycardia, Severe coronary thrombosis, Vascular insufficiency, Ventricular Fibrillation, Ventricular tachycardia
Chemical/Poisoning Alcohol Toxicity, Antifreeze protein, Cannabinoids, Carbon monoxide poisoning, Drug overdose
Dental No underlying causes
Dermatologic Burns, Erythroderma, Exfoliative dermatitis, Psoriasis, Skin disorders
Drug Side Effect Acetaminophen and Oxycodone, Antidepressants, Antimanic agents, Antipsychotics, Anxiolytics, Beta blockers, Chlordiazepoxide, Chlorpromazine, Cidofovir, clobazam, Clorazepate,Diazepam, Flurazepam, General anesthesia, Gray baby syndrome, Levomepromazine, Nitrazepam, opioids, Pergolide, Phenobarbital, Oral antihyperglycemics, Melatonin
Ear Nose Throat No underlying causes
Endocrine Congenital hyperinsulinism, Diabetes mellitus, Hypoadrenalism, Hypoglycemia, Hypopituitarism, Hypothyroidism, Myxedema coma, Myxedema
Environmental Cold exposure, Drowning, Environmental exposure, Immersion in cold water, Swimming, Therapeutic Hypothermia
Gastroenterologic Fulminant Hepatic Failure, Pancreatitis , Severe hepatic cirrhosis
Genetic DOPA decarboxylase deficiency, Gamma-Hydroxybutyrate Toxicity
Hematologic Blood transfusion and complications, Hemorrhagic Diathesis
Iatrogenic Cardiopulmonary bypass, Cold infusion, Induced hypothermia, Induced vasodilation, Major operation, Spinal analgesia
Infectious Disease Community-acquired pneumonia, Overwhelming infection, Sepsis, Shock
Musculoskeletal/Orthopedic No underlying causes
Neurologic Anoxic brain injury, Apnea, Brain death, Cerebral edema, Cerebral hypoxia, Cerebral trauma, Cerebrovascular accident, Cerebrovascular injury, Coma, Hypothalamic dysfunction, Multiple sclerosis, Neuromuscular inefficiency, Neuropathies, Parkinsonism, Spinal cord lesion, Spinal-cord transection, Hemorrhagic Stroke, Ischemic Stroke, Subarachnoid hemorrhage
Nutritional/Metabolic Anorexia nervosa, kwashiorkor, Malnutrition, Starvation
Obstetric/Gynecologic Emergent deliveries, Premature labour and/or delivery, Anorexia nervosa
Oncologic Carcinomatosis, Terminal malignant disease
Ophthalmologic No underlying causes
Overdose/Toxicity Barbiturate Toxicity, Benzodiazepine Toxicity, Ethylene Glycol Toxicity, Narcotics Toxicity, Organophosphate poisoning, Sedative-Hypnotics Toxicity, Toxins
Psychiatric No underlying causes
Pulmonary Pulmonary embolism, Pulmonary thrombectomy
Renal/Electrolyte Continuous renal replacement therapy, Uremia
Rheumatology/Immunology/Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous Arginosuccinic aciduria, Decreased heat production, Euthyroid sick syndrome, Exercise, Extremes of age, Immobility, Impaired shivering, Inactivity, Insufficient fuel, Lactic Acidosis, Paradoxical undressing, Subcutaneous fat necrosis of the newborn, Wernicke’s encephalopathy

Causes in Alphabetical Order


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Differentiating Hypothermia from other Diseases

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Hypothermia is the opposite of hyperthermia. Because the words sound alike, they are easily confused.

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Epidemiology and Demographics

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Risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Risk Factors

Persons most likely to experience hypothermia include those who are:

  • Very old or very young
  • Chronically ill, especially who have heart or blood flow problems
  • Malnourished
  • Overly tired
  • Under the influence of alcohol or drugs

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Natural History, Complications and Prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Complications

Paradoxical Undressing

20% to 50% of hypothermal deaths are associated with, or even caused by, a phenomenon known as paradoxical undressing. When this occurs, the hypothermic victim becomes seriously confused and starts discarding clothing they have been wearing, a counter-productive action which increases the rate of temperature loss. There have been several published case studies of victims throwing off their clothes before help reached them.

Rescuers who are trained in mountain survival techniques have been taught to expect this effect. However, the phenomenon still regularly leads police to incorrectly assume that urban victims of hypothermia have been subjected to a sexual assault.

One explanation for the effect is a cold-inducted malfunction of the hypothalamus, the part of the brain that regulates body temperature. Another explanation is that the muscles contracting peripheral blood vessels become exhausted and relax, leading to a sudden surge of blood (and heat) to the extremities, fooling the victim into feeling warm.

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Diagnosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | Other diagnostic studies

Treatment

Treatment

Medical Therapy | Surgery | Primary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case Studies

Case #1

Related Chapters

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