Obsessive-compulsive disorder
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Priyanka Kumari, M.B.B.S[2]Abhishek Reddy , Sonya Gelfand
Synonyms and keywords: OCD
Overview
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Priyanka Kumari, M.B.B.S[2] Sonya Gelfand
Overview
Obsessive Compulsive disorder is a psychiatric condition characterized by recurrent undesirable thoughts or sensations (obsessions) that cause patients to do something repetitively (compulsions). WHO listed this disorder among one of the top 10 psychiatric disorders that can affect the quality of life.
Historical Perspective
Classification
Obsessive compulsive disorder is classified in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) as an anxiety disorder. According to the American Psychiatric Association there will be change in the classification of OCD and associated conditions into DSM-5 once the the fifth edition of the DSM scheduled for release in May 2013 comes out.
Pathophysiology
Different biological and psychological explanations have been put forward to understand the pathophysiology of obsessive-compulsive disorder. It is generally agreed that neurotransmitters play an important role in the pathophysiology of obsessive–compulsive disorder.
Causes
It is generally agreed that neurotransmitters, biological, psychological, and environmental factors all play a probable role in causing obsessive–compulsive disorder.
Differentiating Obsessive Compulsive Disorder from other Diseases
The differential diagnosis of obsessive-compulsive disorder (OCD) includes tics, mood and anxiety disorders, and other compulsive behaviors, such as trichotillomania or neurodermatitis.
Epidemiology and Demographics
Once believed to be rare, OCD was found to have a lifetime prevalence of 2,300 per 100,000 (2.3%) of the overall population. The twelve month prevalence of OCD is 1,200 per 100,000 (1.2%) of the overall population. Discovery of effective treatments and education of patients and health care providers have significantly increased the identification of individuals with OCD. International studies have shown a similar incidence and prevalence of OCD worldwide.
Risk Factors
Risk factors for obsessive compulsive disorder include genetic predisposition, a variety of genetic factors, environmental factors, and brain structure and function.
Screening
This screening test for obsessive-compulsive disorder is designed as a guide to find out whether one shows symptoms similar to those of obsessive-compulsive disorder (OCD). The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) is considered as a gold standard to screen for the symptoms and severity of obsessive compulsive disorder.
Natural History, Complication and Prognosis
The course of obsessive compulsive disorder is difficult to predict, and minimal research has been done on it. However, it is known that stress exacerbates the symptoms of OCD, and if left untreated, OCD often develops into a chronic condition that presents varying complications and results in an overall poor quality of life.
Diagnosis
History and Symptoms
Obsessive-compulsive disorder (OCD) is a psychiatric anxiety disorder most commonly characterized by a subject’s obsessive, distressing, intrusive thoughts and related compulsions (tasks or “rituals”) which attempt to neutralize the obsessions.
Physical Examination
Although obsessive-compulsive disorder is a mental health problem, certain physical examinations are done to pin point the diagnosis for OCD.
Laboratory Findings
The laboratory tests for obsessive compulsive disorder may include a complete blood count (CBC), screening for alcohol and drugs, and a check of the thyroid function.
Electrocardiogram
X-ray
Echocardiography and Ultrasound
CT scan
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
According to the Expert Consensus Guidelines for the Treatment of obsessive-compulsive disorder, behavioral therapy (BT), cognitive therapy (CT), medications, or any combination of the three are first-line treatments for OCD. Psychodynamic psychotherapy may help in managing some aspects of the disorder, but there are no controlled studies that demonstrate effectiveness of psychoanalysis or dynamic psychotherapy in OCD. Though there is no known treatment for full remission of OCD yet, there are a number of successful treatment options available to promote significant improvement.
Interventions
Surgery
Primary Prevention
Secondary Prevention
References
Historical Perspective
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Priyanka Kumari, M.B.B.S[2] Sonya Gelfand, Abhishek Reddy
Overview
Obsessive-compulsive disorder is an anxiety disorder. In obsessive-compulsive disorder people have unwanted and repeated thoughts, feelings, and ideas which are intrusive and unwanted, and are called obsessions. They also display behaviors called compulsions which are also unwanted, and negatively interfere with the sufferers life. The person often carries out these compulsions in order to rid themselves of the obsessive thoughts, but this only provides temporary relief. Not performing the obsessive rituals or tasks can cause the sufferer great anxiety.
Historical Perspective
Discovery
- In the 19th century, ideas of what compulsions and personal obsessions were became a main area of study and analysis.[1]
- The start of the 20th century brought the largest advancement in the study of obsessions and compulsions as more psychiatrists started to link the two symptoms to one another.
- Sigmund Freud and Pierre Janet were the two most influential people in bringing OCD to the modern level of understanding and diagnosis. Freud’s concept combined the idea of cause and effect, meaning that the obsessions created a need for the compulsions or repetitive behaviors. Janet however, put forth the idea that the cause of the obsessions stemmed from the inability of the person to use a particular type of nervous energy to complete high level of cognitive tasks.
- The generic term “obsessive compulsive disorder” is not a term that was created in the traditional sense. No one person discovered “obsessive compulsive disorder” rather it was a collective effort of many mental health professionals over a period of many years.
Famous Cases
- Martin Luther (1483-1546), the first and most important leader of the Protestant Reformation in Europe suffered from OCD.
- Dr. Samuel Johnson (1709-1784), accredited with compiling the first dictionary of the English language, suffered from a compulsion of “odd movements”.
- Eminent evolutionist Charles Darwin (1809-1882) is now also a well-known historical figure who suffered from OCD.
- Howard Hughes (1905 -1976) is perhaps the most famous person known to have suffered with OCD in more recent times. He was the twentieth century American aviator, engineer, industrialist, film producer, film director, philanthropist, and one of the wealthiest people in the world, whose story was told in the 2004 film, “The Aviator”.
- Engineer Nikola Tesla (1856-1943) displayed a number of characteristics that indicate that he suffered from OCD.
- American Civil War general Thomas “Stonewall” Jackson’s (1824-1863) odd behaviors suggest that, despite his prominent achievements, he suffered from OCD.
- Lawyer Ernst Lanzer (1878-1914) was given the nickname “Rat Man” by Sigmund Freud due to his odd compulsion of having an obsession with nightmarish fantasies about rats.
Overview
Historical Perspective
Discovery
- There is limited information about the historical perspective of [disease name].
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- [Disease name] was first discovered by [name of scientist], a [nationality + occupation], in [year]/during/following [event].
- The association between [important risk factor/cause] and [disease name] was made in/during [year/event].
- In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].
- In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].
Landmark Events in the Development of Treatment Strategies
Impact on Cultural History
Famous Cases
The following are a few famous cases of [disease name]:
References
- ↑ Sources used include Stanford School of Medicine and the National Institute of Mental Health.
Classification
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Priyanka Kumari, M.B.B.S[2] Sonya Gelfand, Abhishek Reddy
Overview
Obsessive-compulsive disorder (OCD) may be classified into three categories based on co-morbiditiy into OCD simole complex, OCD co-morbid tic-related class, and OCD co-morbid affective-related class.
Classification
Subclassification Based on Co-morbidity
- OCD can be classified into three categories based on co-morbidity:[1]
- An OCD simplex class, where major depressive disorder (MDD) is the most common additional disorder.
- An OCD co-morbid tic-related class, where tics are prominent and affective syndromes are considerably rarer.
- An OCD co-morbid affective-related class where panic disorder and affective syndromes are common.
Overview
There is no established system for the classification of [disease name].
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[Disease name] may be classified according to [classification method] into [number] subtypes/groups: [group1], [group2], [group3], and [group4].
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[Disease name] may be classified into [large number > 6] subtypes based on [classification method 1], [classification method 2], and [classification method 3]. [Disease name] may be classified into several subtypes based on [classification method 1], [classification method 2], and [classification method 3].
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Based on the duration of symptoms, [disease name] may be classified as either acute or chronic.
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If the staging system involves specific and characteristic findings and features: According to the [staging system + reference], there are [number] stages of [malignancy name] based on the [finding1], [finding2], and [finding3]. Each stage is assigned a [letter/number1] and a [letter/number2] that designate the [feature1] and [feature2].
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The staging of [malignancy name] is based on the [staging system].
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There is no established system for the staging of [malignancy name].
Classification
There is no established system for the classification of [disease name].
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[Disease name] may be classified according to [classification method] into [number] subtypes/groups:
- [Group1]
- [Group2]
- [Group3]
- [Group4]
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[Disease name] may be classified into [large number > 6] subtypes based on:
- [Classification method 1]
- [Classification method 2]
- [Classification method 3]
[Disease name] may be classified into several subtypes based on:
- [Classification method 1]
- [Classification method 2]
- [Classification method 3]
OR
Based on the duration of symptoms, [disease name] may be classified as either acute or chronic.
OR
If the staging system involves specific and characteristic findings and features:
According to the [staging system + reference], there are [number] stages of [malignancy name] based on the [finding1], [finding2], and [finding3]. Each stage is assigned a [letter/number1] and a [letter/number2] that designate the [feature1] and [feature2].
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The staging of [malignancy name] is based on the [staging system].
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There is no established system for the staging of [malignancy name].
References
- ↑ Nestadt G, Di CZ, Riddle MA, Grados MA, Greenberg BD, Fyer AJ; et al. (2009). “Obsessive-compulsive disorder: subclassification based on co-morbidity”. Psychol Med. 39 (9): 1491–501. doi:10.1017/S0033291708004753. PMC 3039126. PMID 19046474.
Pathophysiology
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Priyanka Kumari, M.B.B.S[2]Sonya Gelfand
Overview
Different biological and psychological explanations have been put forward to understand the pathophysiology of obsessive-compulsive disorder. It is generally agreed that neurotransmitters play an important role in the pathophysiology of obsessive–compulsive disorder.
Pathophysiology
- Obsessive-compulsive disorder is thought to be caused by a variety of factors. Some forms of OCD appear to be familial and linked to other disorders such as tic disorders, depression, and obsessive compulsive personality disorder, while others appear to be familial but unrelated to other disorders, and even others display no family background.[1][2]
- A type of size abnormality has been discovered in various brain structures, according to some studies. The majority of researchers conclude that there is an abnormality in the neurotransmitter serotonin, as well as other potential psychological or biological abnormalities; however, this activity may be the brain’s reaction to OCD rather than its trigger.
- Serotonin is believed to play a role in anxiety regulation, as well as other processes including sleep and memory. Synapses enable this neurotransmitter to travel from one nerve cell to the next. Serotonin must bind to receptor sites on neighboring nerve cells in order to transmit chemical messages. It’s thought that OCD patients’ receptor sites are blocked or impaired, preventing serotonin from reaching its full potential. The fact that many OCD patients benefit from the use of selective serotonin reuptake inhibitors (SSRIs), a type of antidepressant medication that allows more serotonin to be readily available to other nerve cells, backs up this theory. (See the section on potential OCD treatments for more information on this class of drugs.)[3]
- A possible genetic mutation that causes OCD has been discovered in recent research. In unrelated families with OCD, researchers funded by the National Institutes of Health discovered a mutation in the human serotonin transporter gene, hSERT. Furthermore, Rasmussen (1994) produced data in his study of identical twins that supported the idea of a “heritable factor for neurotic anxiety.” He also mentioned that how these anxiety symptoms are expressed is influenced by environmental factors. However, various studies on this topic are still ongoing, and the existence of a genetic link has yet to be proven.[4]
- In August 2007, scientists at Duke University Medical Center in North Carolina discovered another possible genetic cause of OCD. They created mice that were missing a gene called SAPAP3. This protein is abundant in the striatum, a brain region associated with planning and taking appropriate actions. The mice groomed themselves three times as much as normal mice, to the point where their fur fell off.[5]
- Brain imaging is now possible thanks to technological advancements. It has been demonstrated using tools such as positron emission tomography (PET scans) that people with OCD have brain activity that differs from people who do not have the disorder. This suggests that OCD sufferers’ brain functioning may be hampered in some way. According to Jeffrey Schwartz’s book Brain Lock, OCD is caused by the part of the brain that is responsible for translating complex intentions (e.g., “I will pick up this cup”) into fundamental actions (e.g., “move arm forward, rotate hand 15 degrees, etc.) failing to correctly communicate the chemical message that an action has been coerced. This is experienced as a sense of doubt and incompleteness, prompting the individual to attempt to consciously deconstruct their previous behavior — a process that causes anxiety in most people, even those who do not have OCD.
- A miscommunication between the orbital-frontal cortex, the caudate nucleus, and the thalamus has been proposed as a possible factor in the explanation of OCD. The orbitofrontal cortex (OFC) is the first part of the brain to notice if there is a problem. When the OFC detects a problem, it sends a preliminary “worry signal” to the thalamus. When the thalamus receives this signal, it transmits signals to the OFC, which the OFC interprets. Between the OFC and the thalamus is the caudate nucleus, which prevents the initial worry signal from being sent back to the thalamus after it has already been received. However, it is thought that in people with OCD, the caudate nucleus does not function properly, allowing the initial signal to reappear. The thalamus becomes hyperactive as a result, and a seemingly endless loop of worry signals is sent back and forth between the OFC and the thalamus. In an attempt to alleviate this apprehension, the OFC increases anxiety and engages in compulsive behaviors.[3]
Neuropsychiatry
- The striatum, orbitofrontal cortex, and cingulate cortex are the brain regions most affected by OCD. Several receptors including glutamate receptors (NMDA and non-NMDA), the H2, M4, nk1, are involved in OCD. A secondary effect is mediated by the 5-HT1D, 5-HT2C, and opioid receptors. The striatum is home to the H2, M4, nk1, and non-NMDA glutamate receptors, while the cingulate cortex is home to the NMDA receptors.
- The activity of certain receptors is positively correlated to the severity of OCD, whereas the activity of certain other receptors is negatively correlated to the severity of OCD. Those correlations are as follows:
- Activity positively correlated to severity:
- H2
- M4
- nk1
- non-NMDA glutamate receptors
- Activity negatively correlated to severity:
- The receptors nk1, non-NMDA glutamate receptors, and NMDA may be involved in the central dysfunction of OCD, whereas the other receptors may simply have secondary modulatory effects.
- Aprepitant (nk1 antagonist), riluzole (glutamate release inhibitor), and tautomycin are examples of pharmaceuticals that act directly on those core mechanisms (NMDA receptor sensitizer).
- The OC Foundation is also testing the anti-Alzheimer’s drug memantine, which is an NMDA antagonist, for its efficacy in reducing OCD symptoms. Memantine may be considered for treatment-resistant OCD, according to a case study published in The American Journal of Psychiatry, but controlled studies are needed to support this assertion. Drugs used to treat the OCD are not fully efficacious as they are not thought to act on the core mechanisms responsible to cause OCD.[6]
Overview
The exact pathogenesis of [disease name] is not fully understood.
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It is thought that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
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[Pathogen name] is usually transmitted via the [transmission route] route to the human host.
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Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
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[Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
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The progression to [disease name] usually involves the [molecular pathway].
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The pathophysiology of [disease/malignancy] depends on the histological subtype.
Pathophysiology
Physiology
The normal physiology of [name of process] can be understood as follows:
Pathogenesis
- The exact pathogenesis of [disease name] is not completely understood.
OR
- It is understood that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
- [Pathogen name] is usually transmitted via the [transmission route] route to the human host.
- Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
- [Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
- The progression to [disease name] usually involves the [molecular pathway].
- The pathophysiology of [disease/malignancy] depends on the histological subtype.
Genetics
[Disease name] is transmitted in [mode of genetic transmission] pattern.
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Genes involved in the pathogenesis of [disease name] include:
- [Gene1]
- [Gene2]
- [Gene3]
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The development of [disease name] is the result of multiple genetic mutations such as:
- [Mutation 1]
- [Mutation 2]
- [Mutation 3]
Associated Conditions
Conditions associated with [disease name] include:
- [Condition 1]
- [Condition 2]
- [Condition 3]
Gross Pathology
On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Overview
The exact pathogenesis of [disease name] is not fully understood.
OR
It is thought that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
OR
[Pathogen name] is usually transmitted via the [transmission route] route to the human host.
OR
Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
OR
[Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
OR
The progression to [disease name] usually involves the [molecular pathway].
OR
The pathophysiology of [disease/malignancy] depends on the histological subtype.
Pathophysiology
Physiology
The normal physiology of [name of process] can be understood as follows:
Pathogenesis
- The exact pathogenesis of [disease name] is not completely understood.
OR
- It is understood that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
- [Pathogen name] is usually transmitted via the [transmission route] route to the human host.
- Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
- [Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
- The progression to [disease name] usually involves the [molecular pathway].
- The pathophysiology of [disease/malignancy] depends on the histological subtype.
Genetics
[Disease name] is transmitted in [mode of genetic transmission] pattern.
OR
Genes involved in the pathogenesis of [disease name] include:
- [Gene1]
- [Gene2]
- [Gene3]
OR
The development of [disease name] is the result of multiple genetic mutations such as:
- [Mutation 1]
- [Mutation 2]
- [Mutation 3]
Associated Conditions
Conditions associated with [disease name] include:
- [Condition 1]
- [Condition 2]
- [Condition 3]
Gross Pathology
On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease nam
References
- ↑ Pauls DL, Alsobrook JP, Goodman W, Rasmussen S, Leckman JF (1995). “A family study of obsessive-compulsive disorder”. Am J Psychiatry. 152 (1): 76–84. doi:10.1176/ajp.152.1.76. PMID 7802125.
- ↑ Ozaki N, Goldman D, Kaye WH, Plotnicov K, Greenberg BD, Lappalainen J; et al. (2003). “Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype”. Mol Psychiatry. 8 (11): 933–6. doi:10.1038/sj.mp.4001365. PMID 14593431.
- ↑ BBC Science and Nature: Human Body and Mind. Causes of OCD. <http://www.bbc.co.uk/science/humanbody/mind/articles/disorders/causesofocd.shtml>. Accessed April 15, 2006.
- ↑ Rasmussen, S.A. “Genetic Studies of Obsessive Compulsive Disorder” in Current Insights in Obsessive Compulsive Disorder, eds. E. Hollander; J. Zohar; D. Marazziti & B. Oliver. Chichester, England: John Wiley & Sons, 1994, pp. 105-114.
- ↑ Missing gene creates obsessive-compulsive mouse, New Scientist August 2007
- ↑ Poyurovsky M, Weizman R, Weizman A, Koran L (2005). “Memantine for treatment-resistant OCD”. The American journal of psychiatry. 162 (11): 2191–2. doi:10.1176/appi.ajp.162.11.2191-a. PMID 16263867.
Causes
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [5]; Associate Editor(s)-in-Chief: Priyanka Kumari, M.B.B.S[6] Sonya Gelfand, Abhishek Reddy
Overview
It is generally agreed that neurotransmitters, biological, psychological, and environmental factors all play a potential role in causing obsessive–compulsive disorder.
Causes
Behavioral
- Compulsions, according to learning theorists, may be a person’s response to anxiety or discomfort. Compulsions, in particular, are thought to be responses that help a person avoid or reduce the anxiety and discomfort associated with a particular obsession or urge.[1]
- Some theorists also believe that misinterpretation of intrusive thoughts leads to obsessive and compulsive behaviors. People with OCD misinterpret these intrusive thoughts as being important, personally significant, or having disastrous consequences, and as a result, engage in compulsive behavior to combat, resist, or neutralize the distress they cause.[1]
Psychological
- Different species have evolved to protect themselves by gathering or hoarding food and constantly scanning the environment for potential threats. These evolutionary traits, which have been passed down through generations, could be a psychological cause of OCD.[2]
Biological
- OCD has been linked to abnormalities in the neurotransmitter serotonin. Individuals suffering from OCD may have serotonin receptors that are understimulated, according to a theory. This theory is supported by the fact that many OCD patients benefit from the use of selective serotonin reuptake inhibitors (SSRIs), a type of antidepressant that increases serotonin availability to serotonin receptors.
- In unrelated families with OCD, a mutation in the human serotonin transporter gene, hSERT, has been discovered.[5]
- People with OCD had higher volumes of regional grey matter extending from bilateral lenticular nuclei, to the caudate nuclei, and lower volumes in bilateral dorsal medial frontal/anterior cingulate gyri.[6]
- PANDAS, a syndrome linked to Group A streptococcal infections, or immunologic reactions to other pathogens may cause rapid onset of OCD in children and adolescents. [7]
Neurotransmitters role
- People with OCD have a different pattern of brain activity than people without OCD, as per brain scans. The scans also reveal different circuitry functioning in the striatum.[8]
- Individuals with OCD have abnormal dopamine and serotonin activity in various brain regions, which can be classified as dopaminergic hyperfunction in the prefrontal cortex and serotonergic hypofunction in the basal ganglia.[9]
Stress
- OCD is not caused by stress, but it can be triggered by a stressful event. If OCD is not treated, anxiety and stress in one’s life will significantly worsen symptoms. Problems at school or at work, as well as problems in everyday relationships, could all contribute to a person’s OCD becoming more frequent and severe.[10]
Trauma
- According to researchers, people who have experienced physical or sexual trauma are more likely to develop OCD.[11]
Overview
Disease name] may be caused by [cause1], [cause2], or [cause3].
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Common causes of [disease] include [cause1], [cause2], and [cause3].
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The most common cause of [disease name] is [cause 1]. Less common causes of [disease name] include [cause 2], [cause 3], and [cause 4].
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The cause of [disease name] has not been identified. To review risk factors for the development of [disease name], click here.
Causes
- ymptom/manifestation] include [cause1], [cause2], and [cause3].
- [Cause] is a life-threatening cause of [disease].
Common Causes
Common causes of [disease name] may include:
- [Cause1]
- [Cause2]
- [Cause3]
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- [Disease name] is caused by an infection with [pathogen name].
- [Pathogen name] is caused by [pathogen name].
Less Common Causes
Less common causes of [disease name] include:
- [Cause1]
- [Cause2]
- [CauseCauses by OrganList the causes of the disease in alphabetical order:
- Cause 1
- Cause 2
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References
- ↑ 1.0 1.1 Maia TV, Cooney RE, Peterson BS (2008). “The neural bases of obsessive-compulsive disorder in children and adults”. Dev Psychopathol. 20 (4): 1251–83. doi:10.1017/S0954579408000606. PMC 3079445. PMID 18838041.
- ↑ Bracha, H. (2006). “Human brain evolution and the “Neuroevolutionary Time-depth Principle:” Implications for the Reclassification of fear-circuitry-related traits in DSM-V and for studying resilience to warzone-related posttraumatic stress disorder”. Progress in Neuro-Psychopharmacology and Biological Psychiatry 30 (5): 827–853. doi:10.1016/j.pnpbp.2006.01.008. PMID 16563589.
- ↑ BBC Science and Nature: Human Body and Mind. Causes of OCD. [1]
- ↑ Abramowitz, Jonathan; et al, Steven; McKay, Dean (2009). “Obsessive-compulsive disorder”. The Lancet 374 (9688): 491–9. doi:10.1192/bjp.bp.108.055046. PMID 19880927.
- ↑ Ozaki, N., D Goldman, W. H., Plotnicov, K., Greenberg, B. D., J Lappalainen, G. R., & Murphy, D. L. (2003). Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype. Molecular Psychiatry, Volume 8, 933-936. [2]
- ↑ PMID 19880927 [3]
- ↑ “PANDAS studies are no longer recruiting patients”.[4] Bethesda, MD: National Institute of Mental Health, Pediatrics and Developmental Neuroscience Branch. 24 February 2009. Retrieved 13 December 2009.
- ↑ “Obsessive-Compulsive Disorder (OCD) – Cause”. 2010-06-21. Retrieved 2011-12-10.
- ↑ “New approach to obsessive-compulsive disorder: dopaminergic theories”
- ↑ What causes OCD
- ↑ Abramowitz JS, Taylor S, McKay D (2009). “Obsessive-compulsive disorder”. Lancet. 374 (9688): 491–9. doi:10.1016/S0140-6736(09)60240-3. PMID 19665647.
Differentiating Obsessive-Compulsive Disorder from other Diseases

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Priyanka Kumari, M.B.B.S[2] Sonya Gelfand, Abhishek Reddy, Kiran Singh, M.D. [3]
Overview
The differential diagnosis of obsessive-compulsive disorder (OCD) includes tics, mood and anxiety disorders, and other compulsive behaviors, such as trichotillomania or neurodermatitis.[1]
Differential Diagnosis
- OCD should be differentiated from the following conditions:[2]
- Anxiety disorders
- Generalized anxiety disorder (GAD)
- Social anxiety
- Eating disorders
- Major depressive disorder(MDD)
- Obsessive-compulsive personality disorder
- Body dysmorphic disorder
- Autism spectrum disorder
- Other compulsive-like behaviors
- Sexual behavior
- Gambling
- Substance use
- Other obsessive-compulsive and related disorders
- Psychotic disorders
- Tics (in tic disorder) and stereotyped movements or Tourette syndrome[3]
- Anxiety disorders
- Certain psychiatric conditions are diagnosed alongside OCD including; Anorexia nervosa, social anxiety disorder, bulimia nervosa, Tourette syndrome, compulsive skin picking, body dysmorphic disorder, and trichotillomania.
- There is some evidence of a link between drug addiction and obsessive compulsive disorder, according to some studies. Panic attacks are common among OCD sufferers. Although those with any anxiety disorder are at a higher risk of drug addiction (possibly as a coping mechanism for the increased levels of anxiety), drug addiction in obsessive compulsive patients may be a type of compulsive behavior rather than a coping mechanism.
- OCD sufferers are also more likely to suffer from depression. Mineka, Watson, and Clark (1998) proposed one explanation for the high rate of depression in OCD populations, stating that people with OCD (or any other anxiety disorder) may feel depressed due to a “out of control” type of feeling.[4]
- PANDAS refers to childhood streptococcal infections (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections) could be responsible for some cases of OCD. Antibodies to streptococcal bacteria become involved in an autoimmune reaction. Though this theory is not conclusive, if it proves to be correct, there is reason to believe that OCD can be “caught” to some extent through strep throat exposure (just as one may catch a cold). If OCD is caused by bacteria, however, there is hope that antibiotics will be used to treat or prevent it in the future.[5]
- OCD sufferers are aware that their thoughts and behaviors are irrational, but they feel compelled to follow them in order to avoid panic or dread. Untreated OCD is often regarded as one of the most vexing and frustrating of the major anxiety disorders because sufferers are consciously aware of their irrationality but powerless to push it away. Most OCD sufferers will hide their behaviors from others to avoid negative attention because they understand the abnormal nature of their compulsions. This, combined with the fact that the compulsions in some sufferers are entirely mental, has earned the disease the moniker “the secret illness.”
- Everyone has unpleasant thoughts at some point in their lives, but these are usually justified concerns that disappear after a reasonable amount of time has passed. People with OCD find it difficult to get any disturbing thoughts out of their heads, which often leads to feelings of distress and anxiety[6][6][7]
- Obsessive-compulsive disorder is frequently confused with obsessive compulsive personality disorder. However, the two are not the same condition. Former disorder is ego dystonic, which means it is incompatible with the sufferer’s self-concept. Ego dystonic disorders cause a great deal of distress because they go against a person’s perception of himself. OCPD, on the other hand, is ego syntonic, which means that the individual accepts that the symptoms of the disorder are compatible with his or her self-image. Ego syntonic disorders, for the most part, are not distressing. People with OCD are often aware that their behavior is irrational, and they are unhappy with their obsessions, but they still feel compelled to follow them. Persons with OCPD, on the other hand, are unaware of anything abnormal about themselves; they will readily explain why their actions are rational, and convincing them otherwise is usually impossible. People with OCD are anxious; people with OCPD, on the other hand, enjoy their obsessions or compulsions.[8] This is a significant difference between these two distinct conditions.
- Frequently, these rationalizations do not apply to the overall behavior, but to each individual; for example, a person who checks their front door obsessively may argue that the time and stress involved in one more check is significantly less than the time and stress involved in being robbed, and thus the check is the better option. In practice, if the individual is still unsure after that check, it is still preferable in terms of time and stress to do another check, and this reasoning can go on indefinitely.
- Overvalued ideas are a symptom of OCD in some people. In such cases, the person with OCD will be unsure whether or not the fears that drive them to perform their compulsions are rational. It is possible to persuade the individual that their fears are unfounded after some discussion. ERP therapy may be more hard to implement to such patients because they are often unwilling to cooperate, at least at first. As a result, OCD has been compared to a disease of pathological doubt, in which the sufferer, while not delusional, is unable to fully comprehend what types of dreaded events are realistically possible and which are not.
- OCD is distinct from compulsive behaviors such as gambling and overeating. People with these disorders usually get some enjoyment out of their activities, whereas OCD sufferers don’t want to do their compulsive tasks and don’t get any pleasure out of them.
References
- ↑ Differential for OCD
- ↑ Rasmussen SA, Eisen JL (1992). “The epidemiology and differential diagnosis of obsessive compulsive disorder”. J Clin Psychiatry. 53 Suppl: 4–10. PMID 1564054.
- ↑ Diagnostic and statistical manual of mental disorders : DSM-5. Washington, D.C: American Psychiatric Association. 2013. ISBN 0890425558.
- ↑ Mineka S, Watson D, Clark LA (1998). “Comorbidity of anxiety and unipolar mood disorders”. Annual review of psychology. 49: 377–412. doi:10.1146/annurev.psych.49.1.377. PMID 9496627.
- ↑ Belkin, L. > “Can You Catch Obsessive-Compulsive Disorder?”. The New York Times Magazine. Retrieved 2006-04-12.
- ↑ Carter, K. “Obsessive-Compulsive Disorder.” PSYC 210 lecture: Oxford College of Emory University. Oxford, GA. 14 Feb. 2006.
- ↑ Barlow, D. H. and V. M. Durand. Essentials of Abnormal Psychology. California: Thomson Wadsworth, 2006.
- ↑ Carter, K. “Obsessive-Compulsive Personality Disorder.” PSYC 210 lecture: Oxford College of Emory University. Oxford, GA. 11 April 2006.
Epidemiology and Demographics
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Priyanka Kumari, M.B.B.S[2]Sonya Gelfand, Abhishek Reddy, Kiran Singh, M.D. [3], Usama Talib, BSc, MD [4]
Overview
Once believed to be rare, OCD was found to have a lifetime prevalence of 2,300 per 100,000 (2.3%) of the overall population. The twelve month prevalence of OCD is 1,200 per 100,000 (1.2%) of the overall population.[1][2] Discovery of effective treatments and education of patients and health care providers have significantly increased the identification of individuals with OCD. International studies have shown a similar incidence and prevalence of OCD worldwide.
Epidemiology and Demographics
- Obsessive compulsive disorder has a lifetime prevalence of 2,300 per 100,000 (2.3 percent), though many cases of OCD go untreated in primary care settings.[2][3]
- The 12-month prevalence of obsessive compulsive disorder in the general population is 1,200 per 100,000 (1.2%).[1]
- Individuals who have not completed high school have a higher lifetime prevalence of OCD (3.4 percent) than those who have (1.9 percent ). Those with a college diploma, on the other hand, have a higher lifetime prevalence (3.1 percent) than those with only a high school diploma (2.4 percent ).
- The average age of onset for OCD is 19.5 years old, but it can range from late adolescence to the mid-20s in both sexes. However, the age of onset for males is younger than that for females.[4]
- According to a 2008 study, OCD symptoms in Japanese patients are similar to those in Western countries, proving that the disorder transcends culture and geography[5]
- Sufferers are thought to have above-average intelligence because the disorder necessitates complicated thinking patterns.
Overview
Epidemiology and Demographics
Prevalence
- The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals worldwide.
- In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide.
- The prevalence of [disease/malignancy] is estimated to be [number] cases annually.
Case-fatality rate/Mortality rate
- In [year], the incidence of [disease name] is approximately [number range] per 100,000 individuals with a case-fatality rate/mortality rate of [number range]%.
- The case-fatality rate/mortality rate of [disease name] is approximately [number range].
Age
- Patients of all age groups may develop [disease name].
- The incidence of [disease name] increases with age; the median age at diagnosis is [#] years.
- [Disease name] commonly affects individuals younger than/older than [number of years] years of age.
- [Chronic disease name] is usually first diagnosed among [age group].
- [Acute disease name] commonly affects [age group].
Race
- There is no racial predilection to [disease name].
- [Disease name] usually affects individuals of the [race 1] race. [Race 2] individuals are less likely to develop [disease name].
Gender
- [Disease name] affects men and women equally.
- [Gender 1] are more commonly affected by [disease name] than [gender 2]. The [gender 1] to [gender 2] ratio is approximately [number > 1] to 1.
Region
- The majority of [disease name] cases are reported in [geographical region].
- [Disease name] is a common/rare disease that tends to affect [patient population 1] and [patient population 2].
Developed Countries
Developing Countries
References
- ↑ 1.0 1.1 Diagnostic and statistical manual of mental disorders : DSM-5. Washington, D.C: American Psychiatric Association. 2013. ISBN 0890425558.
- ↑ 2.0 2.1 Hirschtritt ME, Bloch MH, Mathews CA (2017). “Obsessive-Compulsive Disorder: Advances in Diagnosis and Treatment”. JAMA. 317 (13): 1358–1367. doi:10.1001/jama.2017.2200. PMID 28384832.
- ↑ Osland S, Arnold PD, Pringsheim T (2018). “The prevalence of diagnosed obsessive compulsive disorder and associated comorbidities: A population-based Canadian study”. Psychiatry Res. 268: 137–142. doi:10.1016/j.psychres.2018.07.018. PMID 30025284.
- ↑ Antony, M. M.; F. Downie & R. P. Swinson. “Diagnostic Issues and Epidemiology in Obsessive-Compulsive Disorder”. in Obsessive-Compulsive Disorder: Theory, Research, and Treatment, eds. M. M. Antony; S. Rachman; M. A. Richter & R. P. Swinson. New York: The Guilford Press, 1998, pp. 3-32.
- ↑ Matsunaga, H.; Maebayashi, K., Hayashida, K., Okino, K., Matsui, T., Iketani, T., Kiriike, N., Stein, D. J. (1 February 2008). “Symptom Structure in Japanese Patients With Obsessive-Compulsive Disorder”. American Journal of Psychiatry 165 (2): 251–253. doi:10.1176/appi.ajp.2007.07020340. PMID 18006873. Retrieved 25 January 2012.
Risk Factors
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Priyanka Kumari, M.B.B.S[2] Sonya Gelfand, Abhishek Reddy, Kiran Singh, M.D. [3]
Overview
Risk factors for obsessive compulsive disorder include genetic predisposition, a variety of genetic factors, environmental factors, and brain structure and function.
Risk Factors
Genetic Predisposition
- Research suggests that the condition tends to run in families. A person who has OCD has a 25% chance of having a blood relative who has it. One study found that children inherit OCD symptoms in 45%-60% of cases, while adults inherit the symptoms in 27%-47% of cases.[1]
- People with first-degree relatives who have OCD, especially if the first-degree relative developed OCD as a child or teen, are at a higher risk for OCD.
Genetic Factors
- Presence of other mental or neurologic conditions, such as:[1]
- Anxiety disorders
- Depression
- Tourette’s syndrome
- Attention-deficit hyperactivity disorder
- Substance abuse
- Eating disorders
- Personality disorders
- Streptococcal infection
- PANDAS (pediatric autoimmune neuropsychiatric disorders)
- Pregnancy or post-partum period: OCD symptoms may worsen during, and immediately after pregnancy. In this case, fluctuating hormones can trigger symptoms. Postpartum OCD is characterized by disturbing thoughts and compulsions regarding the baby’s well-being.
Environment
- Experiencing childhood physical or sexual abuse.[1]
- Experiencing a stressful event (major life changes, such as loss of a loved one, divorce, relationship difficulties, problems in school, or abuse).
- Experiencing a traumatic event.
Brain Structure and Functioning
- Experiencing childhood behavioral inhibition.[1]
- Experiencing higher negative emotionality.
Overview
There are no established risk factors for [disease name].
OR
The most potent risk factor in the development of [disease name] is [risk factor 1]. Other risk factors include [risk factor 2], [risk factor 3], and [risk factor 4].
OR
Common risk factors in the development of [disease name] include [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].
OR
Common risk factors in the development of [disease name] may be occupational, environmental, genetic, and viral.
Risk Factors
There are no established risk factors for [disease name].
OR
The most potent risk factor in the development of [disease name] is [risk factor 1]. Other risk factors include [risk factor 2], [risk factor 3], and [risk factor 4].
OR
Common risk factors in the development of [disease name] include [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].
Common Risk Factors
- Common risk factors in the development of [disease name] may be occupational, environmental, genetic, and viral.
- Common risk factors in the development of [disease name] include:
- [Risk factor 1]
- [Risk factor 2]
- [Risk factor 3]
Less Common Risk Factors
- Less common risk factors in the development of [disease name] include:
- [Risk factor 1]
- [Risk factor 2]
- [Risk factor 3]
References
Screening
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Priyanka Kumari, M.B.B.S[2] Sonya Gelfand, Abhishek Reddy, Usama Talib, BSc, MD [3]
Overview
This screening test for obsessive-compulsive disorder is designed as a guide to find out whether one shows symptoms similar to those of obsessive-compulsive disorder (OCD). The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) is considered as a gold standard to screen for the symptoms and severity of obsessive compulsive disorder.
Screening
- Some tests such as a questionnaire can be done for initial screening for obsessive compulsive-disorder but only a trained healthcare professional can make this diagnosis.[1][2]
- The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) is a symptom checklist and severity scale that is administered by a clinician and is considered a valid screening tool in primary care settings. It is classified as a gold standard to screen for the symptoms and severity of obsessive compulsive disorder. The Y-BOCS assesses 64 obsessions and compulsion along wit their severity.[3][4][5]
Overview
There is insufficient evidence to recommend routine screening for [disease/malignancy].
OR
According to the [guideline name], screening for [disease name] is not recommended.
OR
According to the [guideline name], screening for [disease name] by [test 1] is recommended every [duration] among patients with [condition 1], [condition 2], and [condition 3].
Screening
There is insufficient evidence to recommend routine screening for [disease/malignancy].
OR
According to the [guideline name], screening for [disease name] is not recommended.
OR
According to the [guideline name], screening for [disease name] by [test 1] is recommended every [duration] among patients with:
- [Condition 1]
- [Condition 2]
- [Condition 3]
References
- ↑ The Florida obsessive-compulsive OCD screening test
- ↑ Self screen for OCD
- ↑ Hirschtritt ME, Bloch MH, Mathews CA (2017). “Obsessive-Compulsive Disorder: Advances in Diagnosis and Treatment”. JAMA. 317 (13): 1358–1367. doi:10.1001/jama.2017.2200. PMID 28384832.
- ↑ Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL; et al. (1989). “The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability”. Arch Gen Psychiatry. 46 (11): 1006–11. PMID 2684084.
- ↑ Goodman WK, Price LH, Rasmussen SA, Mazure C, Delgado P, Heninger GR; et al. (1989). “The Yale-Brown Obsessive Compulsive Scale. II. Validity”. Arch Gen Psychiatry. 46 (11): 1012–6. PMID 2510699.
Natural History, Complications and Prognosis
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Priyanka Kumari, M.B.B.S[2] Sonya Gelfand, Abhishek Reddy
Overview
The course of obsessive compulsive disorder is difficult to predict, and minimal research has been done on it. However, it is known that stress exacerbates the symptoms of OCD, and if left untreated, OCD often develops into a chronic condition that presents varying complications and results in an overall poor quality of life.[1]
Natural History
- OCD tends to have a waxing and waning course. The fact that many individuals do not seek treatment may be due in part to stigma associated with OCD, and because sufferers of OCD do not realize that what they are suffering from is OCD, mainly because the typical depiction of the disorder in the media and elsewhere only covers a few of the many symptoms of OCD.
Natural History in Cases with History of an Anxiety Disorder in Addition to OCD
- Sufferers of OCD who are married often have an increased likelihood of recovering from OCD due to the protective nature of the individual’s spouse in which the spouse provides support and assistance in addressing symptoms that aide remission.[2][3][4]
- Those with more severe OCD have been found to often be less likely to remit from the disorder.[5]
Complications
- Complications that obsessive-compulsive disorder may cause or be associated with include:[6]
- Health issues such as contact dermatitis due to frequent hand-washing
- Inability to attend work, school or social activities
- Troubled relationships
- Overall poor quality of life
- Suicidal thoughts and behavior
- Anxiety disorders
- Eating disorders
- Alcohol or substance abuse
Prognosis
- OCD almost always results in a reduced overall quality of life.[7]
- Despite the fact that psychological and/or pharmacological treatment may reduce OCD symptoms, there are rarely symptom-free situations.[8]
- Almost 40% of pediatric OCD cases qualify for remission and 40% still have the disorder in adulthood.[9]
Overview
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
OR
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
OR
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of (disease name) usually develop in the first/ second/ third decade of life, and start with symptoms such as ___.
- The symptoms of (disease name) typically develop ___ years after exposure to ___.
- If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
Complications
- Common complications of [disease name] include:
- [Complication 1]
- [Complication 2]
- [Complication 3]
Prognosis
- Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [–]%.
- Depending on the extent of the [tumor/disease progression] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
- The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
- [Subtype of disease/malignancy] is associated with the most favorable prognosis.
- The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.
References
- ↑ What causes OCD
- ↑ Eisen JL, Goodman WK, Keller MB, Warshaw MG, DeMarco LM, Luce DD; et al. (1999). “Patterns of remission and relapse in obsessive-compulsive disorder: a 2-year prospective study”. J Clin Psychiatry. 60 (5): 346–51, quiz 352. PMID 10362449.
- ↑ Steketee G, Eisen J, Dyck I, Warshaw M, Rasmussen S (1999). “Predictors of course in obsessive-compulsive disorder”. Psychiatry Res. 89 (3): 229–38. PMID 10708269.
- ↑ Boschen MJ, Drummond LM, Pillay A, Morton K (2010). “Predicting outcome of treatment for severe, treatment resistant OCD in inpatient and community settings”. J Behav Ther Exp Psychiatry. 41 (2): 90–5. doi:10.1016/j.jbtep.2009.10.006. PMID 19926074.
- ↑ Catapano F, Perris F, Masella M, Rossano F, Cigliano M, Magliano L; et al. (2006). “Obsessive-compulsive disorder: a 3-year prospective follow-up study of patients treated with serotonin reuptake inhibitors OCD follow-up study”. J Psychiatr Res. 40 (6): 502–10. doi:10.1016/j.jpsychires.2005.04.010. PMID 16904424.
- ↑ OCD complications
- ↑ Eddy KT, Dutra L, Bradley R, Westen D (2004). “A multidimensional meta-analysis of psychotherapy and pharmacotherapy for obsessive-compulsive disorder”. Clin Psychol Rev. 24 (8): 1011–30. doi:10.1016/j.cpr.2004.08.004. PMID 15533282.
- ↑ Subramaniam M, Soh P, Vaingankar JA, Picco L, Chong SA (2013). “Quality of life in obsessive-compulsive disorder: impact of the disorder and of treatment”. CNS Drugs. 27 (5): 367–83. doi:10.1007/s40263-013-0056-z. PMID 23580175.
- ↑ Boileau B (2011). “A review of obsessive-compulsive disorder in children and adolescents”. Dialogues Clin Neurosci. 13 (4): 401–11. PMC 3263388. PMID 22275846.
Substance/Medication-induced Obsessive-Compulsive Disorder
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sonya Gelfand, Kiran Singh, M.D. [2]
Overview
According to the DSM-V, substance/medication-induced obsessive-compulsive or related disorder is diagnosed in patients with obsessions and compulsions characteristic of OCD, but that develop during or after substance intoxication or withdrawal or after exposure to medications.
Differential Diagnosis
- Delirium
- Obsessive-compulsive and related disorder (i.e., not induced by a substance)
- Obsessive-compulsive and related disorder due to another medical condition
- Substance intoxication[1]
Diagnostic Criteria
DSM-V Diagnostic Criteria for Substance/Medication-Induced Obsessive-Compulsive and Related Disorder [1]
| “ |
AND
AND
AND
AND
Note: This diagnosis should be made in addition to a diagnosis of substance intoxication or substance withdrawal only when the symptoms in Criterion A predominate in the clinical picture and are sufficiently severe to warrant clinical attention. |
” |
References
- ↑ 1.0 1.1 Diagnostic and statistical manual of mental disorders : DSM-5. Washington, D.C: American Psychiatric Association. 2013. ISBN 0890425558.
Obsessive-Compulsive Disorder Due to Another Medical Condition
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sonya Gelfand, Kiran Singh, M.D. [2]
Overview
According to the DSM-V, obsessive-compulsive disorder due to another medical condition is diagnosed in patients with obsessions and compulsions characteristic of OCD, but that develop as a pathophysiological consequence of another pre-existing medical condition.
Differential Diagnosis
- Associated feature of another mental disorder
- Mixed presentation of symptoms (e.g., mood and obsessive-compulsive and related disorder symptoms).
- Obsessive-compulsive and related disorders (primary)
- Other specified obsessive-compulsive and related disorder or unspecified obsessive compulsive and related disorder
- Substance/medication-induced obsessive-compulsive and related disorders
Diagnostic Criteria
DSM-V Diagnostic Criteria for Obsessive-Compulsive and Related Disorder Due to Another Medical Condition [1]
| “ |
AND
AND
AND
AND
|
” |
References
- ↑ Diagnostic and statistical manual of mental disorders : DSM-5. Washington, D.C: American Psychiatric Association. 2013. ISBN 0890425558.
Diagnosis
Diagnosis
Diagnostic study of choice | History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X-Ray Findings | Echocardiography and Ultrasound | CT-Scan Findings | MRI Findings | Other Imaging Findings | Other Diagnostic Studies
Treatment
Treatment
Medical Therapy | Interventions | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies
Related Chapters
Related Chapters
- Anorexia Nervosa
- Asperger syndrome
- Body dysmorphic disorder
- Compulsive hoarding
- Dermatillomania
- Intrusive thoughts
- Mysophobia
- Obsessive-compulsive personality disorder
- OrbitoFrontal Cortex
- PANDAS – Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections
- Scrupulosity
- Sexual obsessions
- Social Phobia
- Thought suppression
- Tourettes Syndrome
- Trichotillomania
- Yale-Brown Obsessive Compulsive Scale
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