Orbital cellulitis differential diagnosis

Orbital cellulitis must be differentiated from various conditions which affect the eye and present with similar symptoms, and include periorbital cellulitis, cavernous sinus thrombosis, and neoplasia.

Orbital cellulitis may share common features or present similarly to other eye diseases with significantly varying management protocols. Orbital cellulitis must be differentiated from the following:^[1][2]

Orbital cellulitis must be differentiated from other diseases that may cause erythema, fever, and edema, such as:

• Periorbital cellulitis
• Endophthalmitis
• Severe conjunctivitis
• Herpes Zoster Ophthalmicus
• Posterior Scleritis
• Mucormycosis,
• Aspergillosis of the globe
• M.tuberculosis of the globe

Orbital cellulitis must be differentiated from other diseases that may cause proptosis, edema, and visual disturbance, such as:

• Cavernous sinus thrombosis
• Arteriovenous fistula
• Orbital varices

Orbital cellulitis must be differentiated from other diseases that may cause inflammation, proptosis, and visual disturbance, such as:

• Exophthalmos
• Wegener’s granulomatosis
• Sarcoidosis granuloma
• Orbital pseudotumor

Orbital cellulitis must be differentiated from other diseases that may cause edema, visual disturbance, and proptosis, such as:

• Retrobulbar hematoma
• Mucocele
• Dermoid cyst

Orbital cellulitis must be differentiated from other diseases that may cause proptosis such as:

• Bisphosphonate use

Orbital cellulitis must be differentiated from other diseases that may cause erythema, edema, fever, visual disturbance, and proptosis, such as:

• Metastatic carcinoma
• Neurofibroma
• Schwannoma
• Glioma
• Retinoblastoma
• Rhabdomyosarcoma
• Neuroblastoma
• Lymphoma
• Leukemia
• Histiocytosis

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