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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Renal tubular acidosis causes

Introduction

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Ovevriew

Primary causes of renal tubular acidosis include genetic mutations causing defects in the kidney anion exchanger [kAE1] in distal tubule intercalated cells and congenital adrenal hyperplasia. Secondary causes include medications and autoimmune diseases.

Causes

Causes

The following table summarizes the common primary and secondary causes of renal tubular acidosis.[1][2][3]

Primary Causes Secondary Causes
Type 1
  • Familial
    • Autosomal dominant
      • Mainly due to mutations causing defects in the kidney anion exchanger [kAE1] in distal tubule intercalated cells.
  • Autosomal recessive
    • Mainly due to mutations causing defects in V-ATPase in distal tubule intercalated cells.
Type 2
Type 4
References

References

  1. ↑ Haque SK, Ariceta G, Batlle D (December 2012). “Proximal renal tubular acidosis: a not so rare disorder of multiple etiologies”. Nephrol. Dial. Transplant. 27 (12): 4273–87. doi:10.1093/ndt/gfs493. PMC 3616759. PMID 23235953.
  2. ↑ Batlle D, Haque SK (October 2012). “Genetic causes and mechanisms of distal renal tubular acidosis”. Nephrol. Dial. Transplant. 27 (10): 3691–704. doi:10.1093/ndt/gfs442. PMID 23114896.
  3. ↑ Alper SL (2010). “Familial renal tubular acidosis”. J. Nephrol. 23 Suppl 16: S57–76. PMID 21170890.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2] Jogeet Singh Sekhon, M.D. [3] Syed Ahsan Hussain, M.D.[4]