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Hypercalciuria

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Lakshmi Gopalakrishnan, M.B.B.S. [2] Raviteja Guddeti, M.B.B.S. [3]

Synonyms and keywords: Hypercalcuria; calcium levels raised (urine); hypercalcinuria

Overview

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Overview

Hypercalciuria refers to elevated calcium in the urine. Chronic hypercalciuria may lead to impairment of renal function, nephrocalcinosis, and renal insufficiency.

References

Historical Perspective

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Pathophysiology

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Causes

Overview

Causes

Common Causes

Causes by Organ System

Cardiovascular No underlying causes
Chemical / poisoning No underlying causes
Dermatologic No underlying causes
Drug Side Effect Vitamin D, Lithium, Calcitriol toxicity, Ethinyl estradiol and drospirnone, Furosemide, Glucocorticoids
Ear Nose Throat No underlying causes
Endocrine Cushing syndrome, Primary hyperparathyroidism, Hyperthyroidism, Multiple endocrine neoplasia, Neonatal severe primary hyperparathyroidism, Parathyroid carcinoma, Pituitary tumour (growth hormone secreting), Primary parathyroid hyperplasia, Solitary parathyroid adenoma, Acromegaly, Autosomal dominant hypoparathyroidism, Congenital hypothyroidism, Osteoporosis
Environmental Dehydration, Immobility, Zero gravity
Gastroenterologic Wilson disease, Ulcerative colitis
Genetic Autosomal dominant hypoparathyroidism, Metaphyseal chondrodysplasia, Jansen type, Hypophosphatasia, Neonatal severe primary hyperparathyroidism, Wilson disease, X-linked recessive nephrolithiasis type 1, Autosomal dominant hypocalcemia, Autosomal recessive Familial hypomagnesemia with Hypercalciuria and nephrocalcinosis, Congenital hypothyroidism, Dent disease, Lowe’s syndrome, Osteogenesis Imperfecta, Williams syndrome, Bartter syndrome, Hereditary hypophosatemic rickets
Hematologic Leukemia, Lymphoma, Multiple myeloma
Iatrogenic No underlying causes
Infectious Disease Histoplasmosis, Tuberculous granulomas, Acute pyelonephritis
Musculoskeletal / Ortho Metaphyseal chondrodysplasia, Jansen type, Fractures, McCune-Albright syndrome, Osteoporosis, Paget disease of bone, Osteogenesis Imperfecta
Neurologic Acromegaly, Wilson disease
Nutritional / Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic Bone metastases, Leukemia, Lymphoma, Multiple myeloma, Reticulum cell sarcoma, Parathyroid carcinoma, Pituitary tumour (growth hormone secreting), Solitary parathyroid adenoma
Opthalmologic Wilson disease
Overdose / Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal / Electrolyte Dent disease, X-linked recessive nephrolithiasis type 1, Hypokalaemic distal renal tubular acidosis, Proximal renal tubular acidosis, Acute pyelonephritis, Aminoaciduria, Bartter syndrome, Chronic hypokalemia, Cystinosis, Fanconi syndrome, Glycogen storage disease type 1a, Hartnup disease, Hereditary hypophosatemic rickets, Hyperchloremic acidosis, Hypocitraturia, Hypophosphatasia, Medullary cystic kidney disease, Medullary sponge kidney, Nephrocalcinosis, Autosomal dominant hypocalcemia, Autosomal recessive Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC), Dent disease, X-linked recessive nephrolithiasis type 1
Rheum / Immune / Allergy Sarcoidosis
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous Excess Calcium intake, Idiopathic hypercalciuria, Milk-alkali syndrome, Recumbency

Causes in Alphabetical Order

References

  1. Ekinci Z, Karabaş L, Konrad M (2012). “Hypomagnesemia-hypercalciuria-nephrocalcinosis and ocular findings: a new claudin-19 mutation”. Turk. J. Pediatr. 54 (2): 168–70. PMID 22734304.
  2. Hasani Ranjbar S, Amoli MM, Ebrahim Habibi A; et al. (2012). “SLC34A3 Intronic Deletion in a New Kindred with Hereditary Hypophosphatemic Rickets with Hypercalciuria”. J Clin Res Pediatr Endocrinol. 4 (2): 87–91. doi:10.4274/jcrpe.601. PMID 22672866. Unknown parameter |month= ignored (help)
Differentiating Hypercalciuria from other Diseases

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Epidemiology and Demographics

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Risk Factors

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Natural History, Complications and Prognosis

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Diagnosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | CT | MRI | Other Imaging Findings | Other Diagnostic Studies

Treatment

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case Studies

Case #1

Related Chapters

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