Sick sinus syndrome

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

Sick sinus syndrome (SSS) is a term used to describe a number of different abnormal heart rhythms (arrhythmias) caused by a malfunction of the sinus node, the heart’s “natural” pacemaker. It encompasses disorders causing reduced automaticity of the sinoatrial node, exit block, and sinus arrest. The syndrome primarily affects the elderly, and is associated with paroxysmal atrial fibrillation or flutter in approximately half of the patients and with distal conduction disease in up to one tenth of patients. Sick sinus syndrome was first described by Dr. Keith and Dr. Flack, in 1907. In 2015, MYH6 gene mutations were first implicated in the pathogenesis of sick sinus syndrome. In 1972, Dr. Mandel found a new method of assessing sinus node function, known as sinus node recovery time. There is no classification system for sick sinus syndrome. Sick sinus syndrome occurs as an improperly propagated signal from the sinoatrial (SA) node. Age-dependent progressive fibrosis of the sinus nodal tissue and Remodeling of a sinuatrial node are the potential mechanisms of this abnormally formed signal propagation. MYH6 gene may also be involved in the pathogenesis of this condition. Sick sinus syndrome can result in many abnormal heart rhythms (arrhythmias), including sinus arrest, sinus node exit block, sinus bradycardia, and other types of bradycardia (slow heart rate). Sick sinus syndrome may also be caused by a variety of conditions including but not limited to myocardial infarction, atrial fibrillation, drugs or toxins, infections,medications, electrolyte abnormalities, hypothermia, hypoxemia, hypercarbia, and acidosis. Sick sinus syndrome must be differentiated from other cause of syncope, lightheadedness, dizziness, and tachycardia-bradycardia syndrome. The incidence of SSS increases with increasing age, occurring in 1 of every 600 cardiac patients above the age of 65 years old. Sick sinus syndrome (SSS) usually occurs in individuals older than 50 years old. There is no difference in incidence of SSS between men and women. In addition, the black population was found to have a 41% lower risk of developing SSS as compared to the white population. There is insufficient evidence to recommend routine screening for sick sinus syndrome. Sick sinus syndrome natural history progress over decades. Patients are usually asymptomatic at first, but then symptoms may present due to the insufficient blood supply. Sinus pause or severe bradycardia may present with the central nervous system (CNS) under perfusion which manifests with presyncope or syncope. Possible complications of sick sinus syndrome include cerebrovascular events, stroke, transient ischemic events, renal, gastrointestinal hypo-perfusion, thromboembolism, Fatigue and exercise intolerance. The syndrome is progressive, which means it usually gets worse over time. Patients with sick sinus syndrome (SSS) may present with nonspecific symptoms or be asymptomatic. 50 percent of patients present with syncope or pre-syncope related to the decreased cerebral perfusion secondary to bradyarrhythmias or tachyarrhythmias. Some of the symptoms that may develop among patients include memory loss, dizziness or light-headedness, Palpitations, chest pain or angina, shortness of breath, fatigue, and headache. Patients with sick sinus syndrome usually appear normal. Physical examination of patients with sick sinus syndrome is usually remarkable for bradycardia, tachycardia, and signs of the organ hypoperfusion. There is no laboratory findings associated with the diagnosis of sick sinus syndrome. However, electrolyte abnormalities may be one of the causes. Possible metabolic disturbances associated with sick sinus syndrome include hyperkalemia, hypokalemia, hypoglycemia, hypocalcemia, and hypoxia. Sick sinus syndrome is a collection of heart rhythm disorders that include sinus bradycardia, sinus pauses and sinus arrest. Sick sinus syndrome can evolve towards causing atrial fibrillation, atrial flutter, ectopic atrial tachycardia, sinus node reentrant tachycardia, and tachycardia-bradycardia. There are no echocardiography/ultrasound findings associated with sick sinus syndrome. The management of sick sinus syndrome depends on the underlying cause and the presenting symptoms. Asymptomatic patients are usually monitored without therapy. Atropine may be used in the presence of symptoms or hemodynamic compromise. The management of sick sinus syndrome depends on the underlying cause and the presenting symptoms. After correcting the reversible causes of sick sinus syndrome, it can be managed by placing an implantable pacemaker. Indications of the implantable pacemaker include, patients with documented bradycardia and are symptomatic, patients with chronotropic incompetence, sinus node dysfunction secondary to medications necessitated by another medical condition, and patients with heart rate < 40 per minute.

Sick sinus syndrome was first described by Dr. Keith and Dr. Flack, in 1907. In 2015, MYH6 gene mutations were first implicated in the pathogenesis of sick sinus syndrome. In 1972, Dr. Mandel found a new method of assessing sinus node function, known as sinus node recovery time.

There is no classification system for sick sinus syndrome.

Sick sinus syndrome occurs as an improperly propagated signal from the sinoatrial (SA) node. Age-dependent progressive fibrosis of the sinus nodal tissue and Remodeling of a sinuatrial node are the potential mechanisms of this abnormally formed signal propagation. MYH6 gene may also be involved in the pathogenesis of this condition.

Sick sinus syndrome can result in many abnormal heart rhythms (arrhythmias), including sinus arrest, sinus node exit block, sinus bradycardia, and other types of bradycardia (slow heart rate). Sick sinus syndrome may also be caused by a variety of conditions including but not limited to myocardial infarction, atrial fibrillation, drugs or toxins, infections,medications, electrolyte abnormalities, hypothermia, hypoxemia, hypercarbia, and acidosis.

Sick sinus syndrome must be differentiated from other cause of syncope, lightheadedness, dizziness, and tachycardia-bradycardia syndrome.

The incidence of SSS increases with increasing age, occurring in 1 of every 600 cardiac patients above the age of 65 years old. Sick sinus syndrome (SSS) usually occurs in individuals older than 50 years old. There is no difference in incidence of SSS between men and women. In addition, the black population was found to have a 41% lower risk of developing SSS as compared to the white population.

There is insufficient evidence to recommend routine screening for sick sinus syndrome.

Sick sinus syndrome natural history progress over decades. Patients are usually asymptomatic at first, but then symptoms may present due to the insufficient blood supply. Sinus pause or severe bradycardia may present with the central nervous system (CNS) under perfusion which manifests with presyncope or syncope. Possible complications of sick sinus syndrome include cerebrovascular events, stroke, transient ischemic events, renal, gastrointestinal hypo-perfusion, thromboembolism, Fatigue and exercise intolerance. The syndrome is progressive, which means it usually gets worse over time.

Patients with sick sinus syndrome (SSS) may present with nonspecific symptoms or be asymptomatic. 50 percent of patients present with syncope or pre-syncope related to the decreased cerebral perfusion secondary to bradyarrhythmias or tachyarrhythmias. Some of the symptoms that may develop among patients include memory loss, dizziness or light-headedness, Palpitations, chest pain or angina, shortness of breath, fatigue, and headache.

Patients with sick sinus syndrome usually appear normal. Physical examination of patients with sick sinus syndrome is usually remarkable for bradycardia, tachycardia, and signs of the organ hypoperfusion.

There is no laboratory findings associated with the diagnosis of sick sinus syndrome. However, electrolyte abnormalities may be one of the causes. Possible metabolic disturbances associated with sick sinus syndrome include hyperkalemia, hypokalemia, hypoglycemia, hypocalcemia, and hypoxia.

Sick sinus syndrome is a collection of heart rhythm disorders that include sinus bradycardia, sinus pauses and sinus arrest. Sick sinus syndrome can evolve towards causing atrial fibrillation, atrial flutter, ectopic atrial tachycardia, sinus node reentrant tachycardia, and tachycardia-bradycardia.

There are no echocardiography/ultrasound findings associated with sick sinus syndrome.

There are no x-ray findings associated with sick sinus syndrome.

There are no CT scan findings associated with sick sinus syndrome.

There are no MRI findings associated with sick sinus syndrome.

There are no other imaging findings associated with sick sinus syndrome.

There are no other diagnostic studies associated with sick sinus syndrome.

The management of sick sinus syndrome depends on the underlying cause and the presenting symptoms. Asymptomatic patients are usually monitored without therapy. Atropine may be used in the presence of symptoms or hemodynamic compromise.

The management of sick sinus syndrome depends on the underlying cause and the presenting symptoms. After correcting the reversible causes of sick sinus syndrome, it can be managed by placing an implantable pacemaker. Indications of the implantable pacemaker include, patients with documented bradycardia and are symptomatic, patients with chronotropic incompetence, sinus node dysfunction secondary to medications necessitated by another medical condition, and patients with heart rate < 40 per minute.

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

Sick sinus syndrome was first discribed by Dr. Keith and Dr. Flack, in 1907. In 2015, MYH6 gene mutations were first implicated in the pathogenesis of sick sinus syndrome. In 1972, Dr. Mandel found a new method of assessing sinus node function, known as sinus node recovery time.

• Sick sinus syndrome was first discribed by Dr. Keith and Dr. Flack, in 1907.^[1]
• In 2015, MYH6 gene mutations were first implicated in the pathogenesis of sick sinus syndrome.^[2]

• In 1972, Dr. Mandel found a new method of assessing sinus node function, known as sinus node recovery time.^[3]

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

There is no classification system for sick sinus syndrome.

There is no classification system for sick sinus syndrome.

Template:WH Template:WS

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

Sick sinus syndrome occurs as an improperly propagated signal from the sinoatrial (SA) node. Age-dependent progressive fibrosis of the sinus nodal tissue and Remodeling of sinuatrial node are the potential mechanisms of this abnormally formed signal propagation. MYH6 gene may also be involved in the pathogenesis of this condition.

The SA node is a right atrium structure, responsible for the generation and propagation of electric signals throughout the heart. This structure is located at the junction of the crista terminalis at the superior cavoatrial junction. The mechanisms underlying AS node pacemaker remain incompletely understood. However, heart rate is regulated through control of SA nodal automaticity by the autonomic nervous system.^[1][2]

• Sick sinus syndrome occurs as the result of age-dependent progressive fibrosis of the sinus nodal tissue and atrial myocardium. This leads to abnormal formation and propagation of atrial impulse and the resultant bradycardic or pause-related syndromes.^[3][4]
• Studies on familial and congenital presentations of sick sinus syndrome have also revealed genetic contributions to dysfunctional ion channels.^[5]
• Remodeling of sinuatrial node as a result of heart failure and atrial fibrillation can also be causes of increased sinus node recovery time, abnormal propagation of the action potential from the node and changes in nodal sensitivity.^[6][7]

Sick sinus syndrome occurs sporadically in the majority of cases, however it may also occur as a result of genetic mutations.

• Genes involved in the pathogenesis of sick sinus syndrome include:^{[8][9][10][11]}
  • MYH6 gene:recent research has shown a higher incidence of SSS in carriers of a rare variant of the MYH6 gene, which encodes the alpha heavy chain subunit of cardiac myosin.
  • HCN4 gene
  • SCN5A gene

Conditions associated with sick sinus syndrome include:^[4][12]

• Hemochromatosis
• Sarcoidosis
• Amyloidosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2] Ogheneochuko Ajari, MB.BS, MS [3]

Sick sinus syndrome can result in many abnormal heart rhythms (arrhythmias), including sinus arrest, sinus node exit block, sinus bradycardia, and other types of bradycardia (slow heart rate). Sick sinus syndrome may also be caused by a variety of conditions including but not limited to myocardial infarction, atrial fibrillation, drugs or toxins, infections,medications, electrolyte abnormalities, hypothermia, hypoxemia, hypercarbia, and acidosis.

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

• Myocardial infarction
• Myocarditis

Common causes of sick sinus syndrome include:^{[1][2][3][4][5][6][7][8]}

• Atrial fibrillation
• Athletic training
• Drugs or toxins, including:
  • Toluene
  • Organophosphates
  • Tetrodotoxin
  • Cocaine
• Infections:
  • Lyme disease
  • Legionella
  • Psittacosis
  • Typhoid fever
  • Typhus
  • Listeria
  • Malaria
  • Leptospirosis
  • Dengue fever
  • viral hemorrhagic fevers
  • Guillain-Barre
• Medications:
  • Beta blockers
  • Calcium channel blockers
  • Digoxin
  • Sympatholytic medications
  • Antiarrhythmic medications
  • Lithium
• Cardiac surgery
• Electrolyte abnormalities
• Hypothermia
• Hypoxemia, hypercarbia, acidosis
• Coronary artery disease

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

Sick sinus syndrome must be differentiated from other cause of syncope, lightheadedness, dizziness, and tachycardia-bradycardia syndrome. This algotithm shows different types of bradycardia:

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];

The incidence of SSS increases with increasing age, occurring in 1 of every 600 cardiac patients above the age of 65 years old. Sick sinus syndrome (SSS) usually occurs in individuals older than 50 years old. There is no difference in incidence of SSS between men and women. In addition, the black population was found to have a 41% lower risk of developing SSS as compared to the white population.

• The incidence of SSS increases with increasing age, occurring in 1 of every 600 cardiac patients above the age of 65 years old.^[1]

• Sick sinus syndrome (SSS) usually occurs in individuals older than 50 years old.^[1]

• There is no difference in incidence of SSS between men and women.^[2]

• In addition, the black population was found to have a 41% lower risk of developing SSS as compared to the white population.^[3]

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

There is insufficient evidence to recommend routine screening for sick sinus syndrome.

There is insufficient evidence to recommend routine screening for sick sinus syndrome.

Template:WH Template:WS

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Sahar Memar Montazerin, M.D.[2]

Sick sinus syndrome natural history progress over decades. Patients are usually asymptomatic at first, but then symptoms may present due to the insufficient blood supply. Sinus pause or severe bradycardia may present with the central nervous system (CNS) under perfusion which manifests with presyncope or syncope. Possible complications of sick sinus syndrome include cerebrovascular events, stroke, transient ischemic events, renal, gastrointestinal hypo-perfusion, thromboembolism, Fatigue and exercise intolerance. The syndrome is progressive, which means it usually gets worse over time.

• Sick sinus syndrome natural history progress over decades.^[1]
• Patients are usually asymptomatic at first, but then symptoms may present due to the insufficient blood supply.
• Sinus pause or severe bradycardia may present with the central nervous system (CNS) under perfusion which manifests with presyncope or syncope.

Possible complications of sick sinus syndrome include:^[2]

• Cerebrovascular events, stroke, transient ischemic events
• Renal hypoperfusion may result in oliguria.
• Gastrointestinal hypoperfusion which may present with abdominal pain.
• Thromboembolism
• Fatigue and exercise intolerance

• The syndrome is progressive, which means it usually gets worse over time.^[3]
• The long-term outlook is excellent for people who have a permanent pacemaker implanted.
• The long-term progression of SSS is mostly related to the presence and severity of associated coronary or hypertensive cardiac disease.

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