Developer site: The content shown here is test data.

MyEClinic
MyEClinic
Health Dictionary AI Health Chat Find an Online Doctor
A serene Zen garden with raked sand and smooth stones, symbolising clarity and calm

Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

Back to skin conditions

Variable-sized vessel vasculitis

Introduction

Abbreviations: ABG= Arterial blood gas, ANA= Antinuclear antibody, ANP= Atrial natriuretic peptide, ASO= Antistreptolysin O antibody, BNP= Brain natriuretic peptide, CBC= Complete blood count, COPD= Chronic obstructive pulmonary disease, CRP= C-reactive protein, CT= Computed tomography, CXR= Chest X-ray, DVT= Deep vein thrombosis, ESR= Erythrocyte sedimentation rate, HRCT= High Resolution CT, IgE= Immunoglobulin E, LDH= Lactate dehydrogenase, PCWP= Pulmonary capillary wedge pressure, PCR= Polymerase chain reaction, PFT= Pulmonary function test.

Diseases Clinical manifestations Para-clinical findings Gold standard Additional findings
Symptoms Physical examination
Lab Findings Imaging Histopathology
Headache Fever Weight loss Arthralgia Claudication Bruit HTN Focal neurological disorder Biomarker CBC ESR Other CT scan Angiography Ultrasound/ Echocardiography Other
Variable-vessel vasculitis Behçet’s syndrome[1] – – – + – – +/- – CXCL1  Mild anemia, Neutrophilia ↑ Factor V Leiden Focal CNS lesions Aneurysm formation and thrombosis areas Valve vegetations and ventricular thrombi in echocardiography Meningoencephalitis  in MRI Lymphocytic and plasma cell invasion in the prickle cell layer of the epidermis Clinical criteria Genital ulcerations, Oral ulceration
Cogan’s syndrome[2] +/- – – +/- – – – +  Anti-Hsp70 antibodies Anemia, Thrombocytosis ↑ RF, ANA Thickening and enhancement of both posterior sclera  Stenosis, thrombosis or more lesions in aortic root Aortic insufficiency in echocardiography Early interstitial keratitis by slit lamp Muscle necrosis and atrophy resembling myositis – Red eye, Hearing loss, Vertigo
Gastrointestinal disease Inflammatory Bowel Disease[3] +/- + + + + – – – Anti-Saccharomyces cerevisiae antibody (ASCA), P-ANCA Leukocytosis, Anemia ↑  Iron or vitamin deficiency, Stool OB Mesenteric fat stranding, bowel wall enhancement, increased vascularity (comb sign) – Fistulas, Abscesses, Stenosis Grossly denuded mucosa with active bleeding in colonoscopy Crypt abscesses and mucosal ulceration, Granulomas  Endoscopy  GI bleeding
Whipple’s disease[4] + +/- + + + + + + CCR6, Gut-homing marker integrin β7-chain, T whippelii DNA Mild anemia, Neutrophilia ↑ 72-hour fecal fat determination Nonspecific malabsorption – Hepatosplenomegaly – Periodic acid-Schiff–positive macrophages infiltration in lamina propria of the small bowel Broad-spectrum PCR amplifications Cachexia,

Glossitis

Sjögren’s syndrome[5] – – +/- + – – – – Anti-Ro and Anti-La, Anti-alpha-fodrin antibody Anemia,

Leukopenia,

Eosinophilia

↑ Hypergammaglobulinemia, Low bicarbonate level, Hypokalemia  Salt and pepper or honeycomb appearance in parotid glands – Multicystic or reticular pattern in atrophic salivary gland R/O obstructions or strictures with Sialography  Focal aggregates of lymphocytes Schirmer test Keratoconjunctivitis, Gingival inflammation

References

  1. ↑ Yazici H, Fresko I, Yurdakul S (March 2007). “Behçet’s syndrome: disease manifestations, management, and advances in treatment”. Nat Clin Pract Rheumatol. 3 (3): 148–55. doi:10.1038/ncprheum0436. PMID 17334337.
  2. ↑ Iliescu DA, Timaru CM, Batras M, De Simone A, Stefan C (2015). “COGAN’S SYNDROME”. Rom J Ophthalmol. 59 (1): 6–13. PMC 5729811. PMID 27373108.
  3. ↑ Wehkamp J, Götz M, Herrlinger K, Steurer W, Stange EF (2016). “Inflammatory Bowel Disease”. Dtsch Arztebl Int. 113 (5): 72–82. doi:10.3238/arztebl.2016.0072. PMC 4782273. PMID 26900160.
  4. ↑ Dutly F, Altwegg M (2001). “Whipple’s disease and “Tropheryma whippelii““. Clin Microbiol Rev. 14 (3): 561–83. doi:10.1128/CMR.14.3.561-583.2001. PMC 88990. PMID 11432814.
  5. ↑ Stefanski AL, Tomiak C, Pleyer U, Dietrich T, Burmester GR, Dörner T (2017). “The Diagnosis and Treatment of Sjögren’s Syndrome”. Dtsch Arztebl Int. 114 (20): 354–361. doi:10.3238/arztebl.2017.0354. PMC 5471601. PMID 28610655.

Editor-In-Chief:
C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Eiman Ghaffarpasand, M.D. [2]