
Health Dictionary
Reliable, easy-to-read patient information on common medical conditions β written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Vulvar cancer differential diagnosis
Introduction

Overview
Overview
Vulvar cancer must be differentiated from other neoplastic vulvar lesions, non neoplastic vulvar lesions, and infectious disease lesions of vulva.
Differentiating vulvar cancer from other Diseases
Differentiating vulvar cancer from other Diseases
- Vulvar cancer must be differentiated from other neoplastic vulvar lesions such as:
- Paget disease of the vulva
- Vulvar intraepithelial neoplasm (VIN)
- Vulvar cancer must be differentiated from other non neoplastic vulvar lesions such as:
- Lichen sclerosus
- Squamous cell hyperplasia
- Vulvar vestibulitis
- Vulvar cancer must be differentiated from infectious disease lesions of vulva such as:
Other differential considerations include:
| Diseases | Clinical manifestations | Para-clinical findings | Gold standard | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Symptoms | Physical exam | Lab Findings | Imaging | Histopathology | |||||||||||||
| Abnormal
vaginal bleeding |
Abnormal vaginal dyscharge | Pelvic
pain |
Itching or
burning of the vulva |
Other Genitourinary/ Gastrointestinal symptoms | B symptoms | Abdominal pain | Gynecological examinations | Abdominal
mass |
HPV | Pap smear | STI Panel | Ultrasound | MRI | CT Scan | |||
| Vulvar cancer |
+ |
+ | +/- | +/- | + |
|
|
β | β | β | Ultrasound:
|
MRI:
|
|
Biopsy findings: | |||
| Vaginal cancer[1][2][3][4] |
+ |
+ | +/- | +/- | + |
|
|
β | β | β | Ultrasound:
|
MRI:
|
|
Biopsy findings: | |||
| Cervical cancer[5][6][7][8][9][10][11][12] | + | + | + | + |
+ |
|
+ | Β± |
|
Β±Chlamydia |
|
T2-weighted MRIΒ :
|
PET/CT scan:
|
|
|||
| Cervical polyp[13][14][15] |
|
+ | β | β | β | β | β |
|
β | β | β | β |
|
May reveal presence of tumor | CT contrast may show presence of a well defined mass |
|
|
| Cervical leiomyoma[16][17][18][19][20][21][22][23] |
|
+ | + | β |
|
β | + |
|
Β±
|
β | β | β |
|
T2-weighted MRI:
enhancement
|
N/A |
|
|
| Cervical lymphoma[24][25][26] | β | + | β | + | + |
|
+ | β | β | β |
|
MRI:
|
Diffuse heterogeneous uterine/cervical mass & hypoechoic enlarged iliac lymph nodes |
|
| ||
| Cervical sarcoma[27][28][29][30] | Β± | + | β |
|
Β± | + | + | β | β | β |
|
MRI:
|
N/A | ||||
| Cervical erosion(Ectropion)[31][32][33][34][35] |
|
+ | + | Β± |
|
β | + | β | β | β | β | – | N/A | N/A | N/A |
| |
| Cervicitis[36][37][38][39] | + | + |
|
+/- |
|
β | β | β | To detect complications like PID | N/A | N/A | N/A | |||||
| IUD use[40][41][42] |
|
Β± | + | β | +/- |
|
β | β | β | Β± | To detect IUD location and pregnancy | N/A | N/A | N/A | Physical exam and ultrasound | ||
| Pelvic inflammatory diseases[43][44] | + | + |
|
|
Β±Abdominal | β | β | β | Thickened fluid filled fallopian tubes | N/A | May show endometritis | ||||||
| Endometriosis[45][46][47][48][49][50] | Β± | β | β | + |
|
+ | β | β | β |
|
|
Presence of endometrial tissue outside the uterus |
| ||||
| Adenomyosis[51][52][53][54][55] | β | + | β | β | +/- |
|
+/- | β | β | β |
|
MRI:
|
|
|
| ||
| Cervical ectopic pregnancy[56][57] |
|
β | β | β | β | + |
|
β | β |
|
T2-weighted MRI:
T1-weighted MRI:
|
N/A |
| ||||
| DES exposure (Clear cell adenocarcinoma)[58][59][60] | + | +/- | +/- | +/- | + | – | β | β | β | To determine uterine extent | To detect metastases |
|
|
||||
| Paget’s disease of vulva to cervix[61][62][63] | Β± | β | β | β
|
β |
|
β | β | β | β | N/A | MRI:
|
|
|
| ||
| Nabothian cyst[64][65][66][67] | + | β | β | β | – | β | β | β | β |
|
| ||||||
| Rectal cancer[68][69][70][71][72] | – | – | + | – | Weight loss + | LLQ + | NL | + | – | – | +/- | Endoscopic/transrectal US detects tumor extent | Determine tumor stage | Determine tumor stage |
|
Colonoscopy with biopsy | |
| Submucous uterine leiomyoma[73][74][75] | Menorrhagia | – | + | – | – | + | Enlarged, irregular, firm, nontender uterus | + | – | – | – |
|
Provides information on no: of fibroids, size, vascularization, relationship with endometrial cavity & serosal surface | Not required | Not required | Physical examination with Ultrasound | |
| Uterine cancer[76][77][78][79] | + | + | – | + |
|
+ | – | – | – | Thickened endometrial lining >4cm |
|
Not required |
|
Histologic diagnosis | |||
| Vaginal lymphoma[80][81][82] | + | + | + | + | Abdominal/pelvic pain | – | + | Palpable mass between rectum & vagina | +/- | – | – | – | Diffuse mass in external cervical orifice & invading the vagina | Diffuse mass in external cervical orifice & invading the vagina | Not required | CD20 & CD79a positive | Immunohistochemistry & biopsy |
| Vaginal polyp[83][84][85][86] | Postmenopausal bleeding | + | + | + | – | + | Mass protruding from vagina | +/- | – | – | – | To exclude uterine hyperplasia/carcinoma | To determine the extent | N/A | Benign tissue/premalignant cells | Excisional biopsy | |
| Vaginal adenosis[87][88] | +/- | +/- | +/- | – | – | – | Palpable cysts,nodularity or ulcers | – | – | – | – | N/A | N/A | N/A | Columnar cells in the ectocervix | Biopsy with histopathological examination | |
References
References
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|month=ignored (help) - β Wolfgang B. Gaertner, Mary R. Kwaan, Robert D. Madoff & Genevieve B. Melton (2015). “Rectal cancer: An evidence-based update for primary care providers”. World journal of gastroenterology. 21 (25): 7659β7671. doi:10.3748/wjg.v21.i25.7659. PMIDΒ 26167068. Unknown parameter
|month=ignored (help) - β V. Raman Muthusamy & Kenneth J. Chang (2007). “Optimal methods for staging rectal cancer”. Clinical cancer researchΒ : an official journal of the American Association for Cancer Research. 13 (22 Pt 2): 6877sβ6884s. doi:10.1158/1078-0432.CCR-07-1137. PMIDΒ 18006793. Unknown parameter
|month=ignored (help) - β Mohammad Sadegh Fazeli & Mohammad Reza Keramati (2015). “Rectal cancer: a review”. Medical journal of the Islamic Republic of Iran. 29: 171. PMIDΒ 26034724.
- β Jacques Donnez & Marie-Madeleine Dolmans (2016). “Uterine fibroid management: from the present to the future”. Human reproduction update. 22 (6): 665β686. doi:10.1093/humupd/dmw023. PMIDΒ 27466209. Unknown parameter
|month=ignored (help) - β Mohamed Sabry & Ayman Al-Hendy (2012). “Medical treatment of uterine leiomyoma”. Reproductive sciences (Thousand Oaks, Calif.). 19 (4): 339β353. doi:10.1177/1933719111432867. PMIDΒ 22378865. Unknown parameter
|month=ignored (help) - β Sahana Gupta, Jude Jose & Isaac Manyonda (2008). “Clinical presentation of fibroids”. Best practice & research. Clinical obstetrics & gynaecology. 22 (4): 615β626. doi:10.1016/j.bpobgyn.2008.01.008. PMIDΒ 18372219. Unknown parameter
|month=ignored (help) - β “ACOG practice bulletin, clinical management guidelines for obstetrician-gynecologists, number 65, August 2005: management of endometrial cancer”. Obstet Gynecol. 106 (2): 413β25. August 2005. PMIDΒ 16055605.
- β Boruta DM, Gehrig PA, Fader AN, Olawaiye AB (October 2009). “Management of women with uterine papillary serous cancer: a Society of Gynecologic Oncology (SGO) review”. Gynecol. Oncol. 115 (1): 142β153. doi:10.1016/j.ygyno.2009.06.011. PMIDΒ 19592079.
- β Bokhman JV (February 1983). “Two pathogenetic types of endometrial carcinoma”. Gynecol. Oncol. 15 (1): 10β7. PMIDΒ 6822361.
- β Felix AS, Weissfeld JL, Stone RA, Bowser R, Chivukula M, Edwards RP, Linkov F (November 2010). “Factors associated with Type I and Type II endometrial cancer”. Cancer Causes Control. 21 (11): 1851β6. doi:10.1007/s10552-010-9612-8. PMCΒ 2962676. PMIDΒ 20628804.
- β Vera Silva, Paulo Correia, Nuno Oliveira & Luis Sa (2015). “Primary Vaginal Non-Hodgkin’s Lymphoma: Report of a Rare Clinical Entity”. Clinics and practice. 5 (4): 821. doi:10.4081/cp.2015.821. PMIDΒ 26918105. Unknown parameter
|month=ignored (help) - β Feng Wang, Xuquan Jing, Bo Liu, Xue Meng, Xindong Sun, Yongsheng Gao, Linlin Wang & Zheng Fu (2018). “Primary non-Hodgkin’s lymphoma of the vagina: A case report”. Oncology letters. 15 (3): 3504β3507. doi:10.3892/ol.2018.7805. PMIDΒ 29556272. Unknown parameter
|month=ignored (help) - β Salvatore Guastafierro, Amando Tedeschi, Clelia Criscuolo, Maria Celentano, Luigi Cobellis, Raffaele Rossiello & Umberto Falcone (2012). “Primary extranodal non-Hodgkin’s lymphoma of the vagina: a case report and a review of the literature”. Acta haematologica. 128 (1): 33β38. doi:10.1159/000337336. PMIDΒ 22584110.
- β A. I. al-Nafussi, G. Rebello, D. Hughes & K. Blessing (1992). “Benign vaginal polyp: a histological, histochemical and immunohistochemical study of 20 polyps with comparison to normal vaginal subepithelial layer”. Histopathology. 20 (2): 145β150. PMIDΒ 1302457. Unknown parameter
|month=ignored (help) - β Sunil Kumar Samal, Setu Rathod & Seetesh Ghose (2015). “Fibroepithelial Polyps of the Vagina in Pregnancy”. Journal of clinical and diagnostic researchΒ : JCDR. 9 (10): QJ01βQJ02. doi:10.7860/JCDR/2015/13329.6656. PMIDΒ 26557576. Unknown parameter
|month=ignored (help) - β M. Petrova, J. Laco, K. Cervicek & M. Tomsova (2015). “[Tubulo-squamous polyp of the vagina]”. Ceska gynekologie. 80 (3): 173β175. PMIDΒ 26087210. Unknown parameter
|month=ignored (help) - β Alexis Heller, Adanna Ukazu & Qing Wang (2017). “Pseudosarcomatous Vaginal Polyp”. International journal of surgical pathology. 25 (1): 54β55. doi:10.1177/1066896916666676. Unknown parameter
|month=ignored (help) - β Marguerite B. Vigliani (2017). “A Report of Two Cases of Age-Related Changes in Cervical Morphology in Postmenopausal Women with Vaginal Adenosis”. Case reports in obstetrics and gynecology. 2017: 9523853. doi:10.1155/2017/9523853. PMIDΒ 28316850.
- β Tiantian Han, Ying Jin, Yan Li, Yalan Bi & Lingya Pan (2018). “Clinicopathologic features and outcomes of primary vaginal adenosis as a dermatologic and gynecologic burden: A retrospective study”. Medicine. 97 (49): e13470. doi:10.1097/MD.0000000000013470. PMIDΒ 30544435. Unknown parameter
|month=ignored (help)
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]
