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Flatulence

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]

Overview

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]

Overview

Flatulence is the presence of a mixture of gases known as flatus in the digestive tract of mammals expelled from the rectum. It is more commonly known as ‘farting‘, ‘passing gas’, or ‘passing wind’ (UK).

References

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Pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]

Pathphysiology

Flatus is expelled under pressure through the anus, whereby, as a result of the voluntary or involuntary tensing of the anal sphincter, the rapid evacuation of gases from the lower intestine occurs. Depending upon the relative state of the sphincter (relaxed/tense) and the positions of the buttocks, this often results in an audible crackling or trumpeting sound, but gas can also be passed quietly. The olfactory components of flatulence include skatole, indole, and sulfurous compounds.[1] The non-odorous gases are mainly nitrogen (ingested), carbon dioxide (produced by aerobic microbes or ingested), and hydrogen(produced by some microbes and consumed by others), as well as lesser amounts of oxygen (ingested) and methane (produced by anaerobic microbes).[2] Odors result from trace amounts of other components (often containing sulfurcompounds, see below).

Flatus is expelled under pressure through the anus, whereby, as a result of the voluntary or involuntary tensing of the anal sphincter, the rapid evacuation ofgases from the lower intestine occurs. Depending upon the relative state of the sphincter (relaxed/tense) and the positions of the buttocks, this often results in an audible crackling or trumpeting sound, but gas can also be passed quietly. The olfactory components of flatulence include skatole, indole, and sulfurous compounds.[3] The non-odorous gases are mainly nitrogen (ingested), carbon dioxide (produced by aerobic microbes or ingested), and hydrogen(produced by some microbes and consumed by others), as well as lesser amounts of oxygen (ingested) and methane (produced by anaerobic microbes).[4] Odors result from trace amounts of other components (often containing sulfurcompounds, see below).

Composition of Flatus Gases

Nitrogen is the primary gas released. Carbon dioxide is often present, especially in persons who drink carbonated beverages in quantity. Methane andhydrogen, lesser components, are flammable, and so flatus is susceptible to catching fire. Not all humans produce flatus that contains methane. For example, in one study of the feces of nine adults, only five of the samples contained bacteria capable of producing methane.[5]Similar results are found in samples of gas obtained from within the rectum.

The gas released during a flatus event frequently has a foul odor which mainly results from low molecular weight fatty acids such as butyric acid(rancid butter smell) and reduced sulfur compounds such as hydrogen sulfide (rotten egg smell) and carbonyl sulfide that are the result of protein breakdown. The incidence of odoriferous compounds in flatus increases from herbivores, such as cattle, through omnivores to carnivorousspecies, such as cats or dogs. Flatulence odor can also be caused by the presence of large numbers of microflora bacteria and/or the presence of feces in therectum.

The major components of the flatus by percentage are:[6]

Mechanism of Action

The noises commonly associated with flatulence are caused by the vibration of the anal sphincter, and not by the buttocks. The sound varies depending on the tightness of the sphincter muscle and velocity of the gas being propelled, as well as other factors such as water and body fat. The auditory pitch (sound) of the flatulence outburst can also be affected by the anal embouchure. Among humans, farting sometimes happens accidentally, such as incidentally to coughing or sneezing; on other occasions, farting can be voluntarily elicited by tensing the rectum or “bearing down” and subsequently releasing the anal sphincter. Humans are also known to flatulate during sleep, largely due to the relaxed state of body muscles, which results in the average person flatulating about 10-20 times through any given night.

Flatus is brought to the rectum via peristalsis, which also causes feces to descend from the large intestine, and may cause a similar feeling of urgency and discomfort. Nerve endings in the rectum usually enable individuals to distinguish between flatus and feces, although loose stool can confuse the individual, occasionally resulting in accidental defecation.

References

  1. “Flatulence, wind and bloating”. Patient UK. Retrieved 2006-12-11.
  2. Suarez F (1997). “Insights into human colonic physiology obtained from the study of flatus composition”. Am J Physiol. 272 (5 Pt 1): G1028–33. Unknown parameter |coauthors= ignored (help)
  3. “Flatulence, wind and bloating”. Patient UK. Retrieved 2006-12-11.
  4. Suarez F (1997). “Insights into human colonic physiology obtained from the study of flatus composition”. Am J Physiol. 272 (5 Pt 1): G1028–33. Unknown parameter |coauthors= ignored (help)
  5. Miller TL (1982). “Isolation of Methanobrevibacter smithii from human feces”. Appl Environ Microbiol. 43(1): 227–232. Unknown parameter |coauthors= ignored (help)
  6. “Human Digestive System”. Encyclopedia Britannica. Retrieved 2007-08-22.

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Causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Carlos A Lopez, M.D. [2]

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Common Causes

Causes by Organ System

Cardiovascular No underlying causes
Chemical / poisoning Polyethylene glycol
Dermatologic Carbohydrate malabsorption, malabsorption , HIV related malabsorption, intestinal tuberculosis, tropical sprue, whipple’s disease
Drug Side Effect Acetaminophen, acarbose, acamprosate calcium, albuterol , bexarotene, bupropion, butalbital, calcium carbonate , levodopa and carbidopa, cevimeline, cidofovir, chloral hydrate, citalopram , clindamycin, codeine, denosumab, disopyramide, dolutegravir, dulaglutide , etodolac, exenatide, flurbiprofen, glipizide, glycopyrrolate, lactulose, lanreotide, lisinopril, lithium, lovastatin, medications, megestrol acetate, megestrol, meropenem, mesalazine, metformin, midodrine, misoprostol, miglitol, modafinil, moxifloxacin, naproxen, niacin, nitrofurantoin, norfloxacin, octreotide, ofloxacin, oxaprozin, pantoprazole, pergolide, polyethylene glycol, piroxicam, rabeprazole, Human chorionic gonadotropin, rifampicin, ritonavir, simethicone, simvastatin, sotalol, sunitinib, tacrolimus, tramadol, thalidomide, tolcapone, tolmetin, varenicline, vilazodone
Ear Nose Throat No underlying causes
Endocrine Pancreatic cancer, pancreatic disease, pancreatic insufficiency
Environmental No underlying causes
Gastroenterologic Abdominal surgery, aerophagia, alteration of intestinal motility, amebiasis, biliary disease, blastocystis, bowel fermentation, caffeine, carcinoid tumors, celiac disease, cholesterolosis, chronic constipation in adults, chronic diarrhea in developed countries, chronic functional constipation and fecal incontinence in infants and children, chronic mesenteric ischemia, cirrhosis of liver, crohn’s disease, diverticulitis, diverticulosis, fecal incontinence in infants and children, gallbladder disease, gallbladder disorders, gallbladder polyps, gallstone ileus, gallstones, gastric intestinal metaplasia, gastroesophageal reflux disease, gastrointestinal toxicity of radiation therapy, giardiasis, hepatic encephalopathy in adults, hypersalivation, intermittent bowel obstruction, human growth hormone, intestinal bacterial overgrowth, intestinal motility disorders, intestinal obstruction, irritable bowel syndrome, lactase deficiency, metorchis, pancreatic carcinoma, pancreatic insufficiency, pneumatosis intestinalis, postoperative ileus, probiotics for gastrointestinal diseases, short bowel syndrome , small bowel diverticular, swallowed air, lactase deficiency, metorchis, pancreatic carcinoma, pancreatic insufficiency, pneumatosis intestinalis, postoperative ileus, probiotics for gastrointestinal diseases, short bowel syndrome, small bowel diverticular , swallowed air
Genetic Autosomal dominant polycystic kidney disease, cystic fibrosis, colon cancer , enteropathy-type intestinal T-cell lymphoma, glucose-6-phosphatase deficiency
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease Amebiasis, blastomycosis, clonorchis, clostridium difficile, colonic bacterial fermentation, cyclospora infection, dientamoeba fragilis, giardiasis, hookworm infection, metorchis, opisthorchis, small intestine bacterial infection
Musculoskeletal / Ortho Abdominal surgery
Neurologic Hepatic encephalopathy in adults
Nutritional / Metabolic Acarbose, apples, beans, bowel fermentation, brussel sprouts, cabbage, caffeine, malabsorption, carbonated beverages, chewing gum, chronic diarrhea in developed countries, crayfish, dietary factors, eating too quickly, food allergies, glucose-6-phosphatase deficiency, gut fermentation, herbal products, high fiber diet, high legume diet,increased intake of fructose, increased intake of lactose, increased intake of sorbitol, introducing solid foods and vitamin and mineral supplementation during infancy, lactase deficiency, lactulose, lobster, tropical sprue, traveler’s diarrhea, mixed nuts, metabolic syndrome, obesity, onions, peanut, pork, prunes, raisins, shellfish, shrimp, undigestible starches in fruits, undigestible starches in vegetables, undigestible starches legumes
Obstetric/Gynecologic No underlying causes
Oncologic Colon cancer, anal cancer, carcinoid tumors, cirrhosis of liver, enteropathy-type intestinal T-cell lymphoma, pancreatic carcinoma
Ophthalmologic No underlying causes
Overdose / Toxicity No underlying causes
Psychiatric Aerophagia , anxiety
Pulmonary Pneumatosis intestinalis
Renal / Electrolyte Autosomal dominant polycystic kidney disease
Rheum / Immune / Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous 3-month infant due immature gut, aerophagia, eating too quickly, fecal incontinence in infants and children, habitual air swallowing, normal in healthy individuals, normal infant, normal physical needs, obesity


Causes in Alphabetical Order

References

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Differentiating Flatulence from other Diseases

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Epidemiology and Demographics

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Risk Factors

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Diagnosis

Diagnosis

History and Symptoms | Physical Examination| Laboratory Findings | CT | MRI | Abdominal Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Treatment

Medical Therapy | Primary Prevention | Health Effects | Impact

Case Studies

Case Studies

Case #1

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