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Hyperthermia

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Heat stroke; heat prostration; heat exhaustion; sunstroke

Overview

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Hyperthermia in its advanced state referred to as heat stroke or sunstroke, is an acute condition which occurs when the body produces or absorbs more heat than it can dissipate. It is usually due to excessive exposure to heat. The heat-regulating mechanisms of the body eventually become overwhelmed and are unable to effectively deal with the heat, and body temperature climbs uncontrollably. This is a medical emergency that requires immediate medical attention.

Hyperthermia can be created artificially by drugs or medical devices. In these instances it may be used to treat cancer and other conditions. Malignant hyperthermia is a rare complication of some types of general anesthesia.

Hyperthermia is the opposite of hypothermia.

References

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Pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Body temperatures above 40°C (104 °F) are life-threatening. This compares to normal body temperature of 36-37°C (97-98°F). At 41°C (106 °F), brain death begins, and at 45°C (113°F) death is nearly certain. Internal temperatures above 50°C (122°F) will cause rigidity in the muscles and certain, immediate death.

Heat stroke may come on suddenly, but usually follows a less-threatening condition commonly referred to as heat exhaustion or heat prostration.

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Causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]

Overview

Life threatning causes of hyperthermia include diabetic ketoacidosis, heat stroke, malignant hyperthermia, and septic shock. Other common causes of hyperthermia are amphetamine, cocaine, monoamine oxidase inhibitors and selective serotonin reuptake inhibitors.

Causes

Life Threatening Causes

Common Causes

Causes by Organ System

Cardiovascular Dressler syndrome,Kawasaki disease
Chemical/Poisoning Methyl bromide, saponin, acetylsalicylic acid, amphetamine poisoning, anticholinergic poisoning, antipsychotic poisoning, benzphetamine hydrochloride, boric acid, cathinone poisoning, cobra poisoning, cocaine poisoning, cyclic antidepressant poisoning, dinitrocresol, dinitrophenol, funnel web spider poisoning, hexachlorobenzene, lysergic acid diethylamide, MAO inhibitor poisoning, metaldehyde, mustard tree poisoning, nitrogen dioxide, phencyclidine poisoning, salicylate poisoning, strychnine, toxaphene, toxic mushrooms
Dental No underlying causes
Dermatologic Cellulitis, hidradenitis suppurativa, hydroa vacciniforme, impetigo herpetiformis, scarlet fever, thrombotic thrombocytopenic purpura,
Drug Side Effect 5-azacytidine, abacavir, amphetamines, anticholinergics, asparaginase, benztropine mesylate, bleomycin, bretylium tosylate, cocaine, cyclic antidepressant poisoning, dabrafenib, didrex, dimercaprol, dinoprostone, diphtheria-pertussis-tetanus vaccine, elotuzumab, elspar, eribulin mesylate, ganciclovir, glycopyrrolate, imatinib mesylate, ioxilan,LSD, MDMA, methscopolamine bromide, mepenzolate, micafungin, MMR vaccine, monoamine oxidase inhibitors, muscarinic antagonists, oxaliplatin, para-amino salicylic acid, PCP, penicillaminepropantheline bromide, psychostimulant drugs, psychotropic medications, pyrazinamide, selective serotonin reuptake inhibitors, Serotonin syndrome, succimer, Talimogene laherparepvec, tricyclic antidepressants, valganciclovir
Ear Nose Throat Vincent angina
Endocrine De Quervain’s thyroiditis ,diabetic ketoacidosis,pheochromocytoma,thyroid storm
Environmental Humidity
Gastroenterologic Cholecystitis,gallbladder empyema,yellow fever
Genetic Crisponi syndrome,pseudodiastrophic dysplasia,Stuve-Wiedemann dysplasia
Hematologic Acute infantile hemorrhagic oedema, blood transfusion and complications, Burkitt lymphoma, lymphangitis, lymphoma, thrombotic thrombocytopenic purpura, tropical pulmonary eosinophilia
Iatrogenic No underlying causes
Infectious Disease Acute disseminated encephalomyelitis, anthrax, babesiosis, bartonellosis, Bornholm disease, brain abscess, Brazilian purpuric fever, campylobacter jejuni, caspofungin, cellulitis, Chagas disease, Colorado tick fever, common cold, cystitis, infective, dengue, ehrlichia ewingii, encephalitis, epiglottitis, erysipelas,erysipeloid of rosenbach, gallbladder empyema, hand-foot-mouth syndrome, heartland virus, herpes virus 6, human monocytotropic ehrlichiosis, influenza, Kunjin virus, lassa fever, lymphangitis, malaria, measles, mediastinitis, meningitis, Murray Valley encephalitis virus, Nanukayami, Oklahoma tick fever, neonatal sepsis, orbital cellulitis, PCP, pelvic inflammatory disease, pericoronitis, rabies, rickettsia prowazekii, scarlet fever, schistosoma haematobium, secondary syphilis, Sennetsu fever, sepsis, septic shock, smallpox, staphylococcal toxic shock syndrome, subacute sclerosing leukoencephalitis, tanapox virus disease, tetanus, toxic shock syndrome, trench fever, trichinella spiralis, tropical pulmonary eosinophilia, typhoid fever, vincent angina, viral haemorrhagic fever, yellow fever, yersinia pestisZika virus disease,
Musculoskeletal/Orthopedic Malignant hyperpyrexia
Neurologic Acute disseminated encephalomyelitis, Aicardi-Goutieres syndrome, autonomic neuropathy, brain abscess, cerebral hemorrhage, familial hemiplegic migraine, meningitis, status epilepticus, subacute sclerosing leukoencephalitis
Nutritional/Metabolic Calcitriol, dehydration, Gtp cyclohydrolase deficiency, heat cramps, hypernatremia, hyponatremia, Ornithine transcarbamylase deficiency, streptokinase
Obstetric/Gynecologic Pelvic inflammatory disease, puerperal pyrexia
Oncologic Burkitt lymphoma, leukemia, lymphoma, mastocytosis, nephroblastoma
Ophthalmologic Orbital cellulitis
Overdose/Toxicity Autumn crocus, Cocaine overdose, Ecstasy abuse, MDMA
Psychiatric Neuroleptic malignant syndrome
Pulmonary Bronchiolitis obliterans organizing pneumonia, common cold, extrinsic allergic alveolitis, Idiopathic pulmonary haemosiderosis, lymphocytic interstitial pneumonia, mediastinitis, PCP, severe acute respiratory syndrome,
Renal/Electrolyte Nephroblastoma, renal infarction
Rheumatology/Immunology/Allergy Acute disseminated encephalomyelitis, Aicardi-Goutieres syndrome, Interferon beta, Interferon gamma, Interleukin 2, Kawasaki disease, macrophage activation syndrome, thrombotic thrombocytopenic purpura, urate crystal arthropathy
Sexual No underlying causes
Trauma Crush injury
Urologic Cystitis infective, malakoplakia
Miscellaneous Pyrexia of unknown origin

Causes in Alphabetical Order

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References

Differentiating Hyperthermia from other Diseases

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Epidemiology and Demographics

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Risk Factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

While anyone can be affected by hyperthermia, some populations are especially susceptible to heat illness and injury. As noted by Joseph Rampulla in the The Health Care of Homeless Persons: Heat illness most seriously affects the poor, urban-dwellers, young children, those with chronic physical and mental illnesses, substance abusers, the elderly, and people who engage in excessive physical activity under harsh conditions.

References

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Natural History, Complications and Prognosis

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References

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Diagnosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | Other Diagnostic Studies

Treatment

Treatment

Medical Therapy | Primary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case Studies

Case #1

Related Chapters
External Links

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