Malaise causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S.

Overview

Malaise is caused by a large variety of conditions and diseases that result in fatigue and lethargy. Common causes include microbial infection and the side effects of drug therapy.

Causes

Common Causes

2

Causes by Organ System

Cardiovascular	Beta blockers , Congestive heart failure, Cutaneous necrotizing vasculitis, Dressler syndrome, Familial hyperchylomicronemia , Familial lipoprotein lipase deficiency, Infective endocarditis, Lipoprotein lipase deficiency , Myocarditis , Polyarteritis nodosa , Postpericardiotomy syndrome , Temporal arteritis , Vasculitis, Wegener’s granulomatosis
Chemical/Poisoning	3-dichloropropene , Acute radiation sickness, Anthrax, Boric acid, Cutaneous anthrax, Cyclospora cayetanenis food poisoning, Ddd , Ddt, Decreased bicarbonate, Metal fume fever, Methomyl , Pulmonary anthrax , Sea snake poisoning
Dental	Gingivostomatitis, Tooth abscess, Toothache
Dermatologic	Actinic prurigo , Brill disease , Erythema chronicum migrans , Erythema multiforme, Erythema nodosum , Hydroa vacciniforme, Lymphadenopathy, Millian erythema , Mucha-habermann syndrome, Obstructive jaundice, Panniculitis, Pemphigus, Pfeiffer-weber-christian syndrome, Polymorphous light eruption , Scleredema adultorum, Scleroderma, Shingles, Squamous cell skin cancer , Stevens-johnson syndrome, Weber-christian disease, Yellow nail syndrome
Drug Side Effect	Alanycarb , Aldicarb , Aldoxycarb , Aldrin, Allyxycarb, Ambenonium, Aminocarb , Anticonvulsant medicines, Antihistamines, Bcg vaccine, Bendiocarb, Benfuracarb, Beta blockers , Bufencarb, Butacarb, Butocarboxim, Butoxcarboxim, Carbanolate, Carbaryl , Carbofuran, Carbosulfan, Cloethocarb, Decarbofuran, Dexamethasone, Dicresyl, Dieldrin, Dimetan , Dimetilan, Dioxacarb, Diquat dibromide, Ethiofencarb, Fenethacarb, Fenobucarb, Furathiocarb, Hyquincarb, Interferon gamma, Isoprocarb, Lamivudine, Loratadine, Metolcarb, Mexacarbate, Morpholine, Nilutamide, Nitrilacarb, Oxamyl, Pergolide, Pirimicarb, Praziquantel, Promacyl , Promecarb, Propoxur, Sargramostim, Steroid withdrawal syndrome, Sumatriptan, Tazimcarb, Thiocarboxime, Thiodicarb, Thiofanox, Tiagabine, Tretinoin, Trimellitic anhydride, Trimethacarb, Xmc , Xylylcarb, Zidovudine
Ear Nose Throat	Chronic sinusitis, Nasopharyngitis, Sphenoid sinusitis, Tonsilitis
Endocrine	Addington disease , Adenitis, Adrenal gland dysfunction, Brennemann’s syndrome , Fatigue, Hypothyroidism, Multifocal fibrosclerosis, Pituitary gland dysfunction , Post-transplant lymphoproliferative disease , Subacute granulomatous thyroiditis, Subacute thyroiditis, Thyroid disease
Environmental	Acute radiation sickness, Farmer’s lung, Space adaptation syndrome, Stachybotrys chartarum
Gastroenterologic	Abdominal abscess , Acute cholecystitis , Acute fatty liver of pregnancy , Bowel bypass syndrome, Bowel-associated dermatosis-arthritis syndrome, Brennemann’s syndrome , Chronic infectious diarrhea , Colon cancer, Crohns disease, Dana syndrome, Distal colorectal cancer, End stage liver failure , Enteroaggregative e. coli infection , Enterohemorrhagic e. coli infection, Enteroinvasive e. coli infection, Enteropathogenic e. coli infection , Enterotoxigenic e. coli infection , Hamartomatous colorectal cancer, Hellp syndrome, Hepatocellular carcinoma, Hepatoma, Hookworm , Liver abscess, Liver cancer, Obstructive jaundice, Occasional hepatitis, Perirectal abscess, Protozoan infections, Proximal colorectal cancer, Pseudomembranous colitis , Rectractile mesenteritis, Sea sickness, Spleen cancer , Spleen conditions , Spleen neoplasm, Splenic infarct , Sporadic colorectal cancer, Traveler’s diarrhea, Viral digestive infections, Vlcad deficiency , Zieve syndrome
Genetic	Vlcad deficiency , Warm-reacting-antibody haemolytic anemia
Hematologic	Acute myelofibrosis, Acute panmyelosis, Aggressive nk-cell leukaemia, Anemia, Angioimmunoblastic with dysproteinemia lymphadenopathy, Bernard syndrome, Blood cancers , Blood conditions, Bolivian hemorrhagic fever, Burnett’s syndrome, Chronic leukemia , Classical hodgkin disease , Cyclic neutropenia, Dana syndrome, Diabetes , Eijkman’s syndrome, Hellp syndrome, Hemophagocytic lymphohistiocytosis, Hodgkin’s disease , Leukemia, Lymphocyte depletion hodgkin’s disease , Lymphomatoid granulomatosis , Meningococcemia, Mixed cellularity hodgkin’s disease , Myelodysplastic disease , Myeloproliferative diseases , Nodular sclerosing hodgkin’s lymphoma, Pernicious anemia, Philadelphia-negative chronic myeloid leukemia, Polycythemia vera, Sepsis, Severe anemia, Type 2 diabetes, Warm-reacting-antibody haemolytic anemia, X-linked sideroblastic anemia
Iatrogenic	Postpericardiotomy syndrome, Post-transplant lymphoproliferative disease
Infectious Disease	Abdominal abscess , Acute pneumonia, Acute viral syndrome, African sleeping sickness, Aids, American mountain fever, Angiostrongyliasis, Arbovirus, Arcobacter butzleri infection, Arcobacter cryaerophilus infection, Arenavirus, Argentinean hemorrhagic fever , Astroviruses, Avian influenza, Babesiosis, Bolivian hemorrhagic fever, Boutonneuse fever , Breast abscess, Brill disease , Bronchitis, California encephalitis, Campylobacter jejuni subspecies doylei infection, Chagas disease, Chicken pox , Chronic active hepatitis, Chronic infectious diarrhea , Chronic sinusitis, Coccidioidomycosis , Colorado tick encephalitis, Colorado tick fever, Conor’s disease, Delayed viral syndromes, Eastern equine encephalitis, Ehrlichiosis, Enteroaggregative e. coli infection , Enterohemorrhagic e. coli infection, Enteroinvasive e. coli infection, Enteropathogenic e. coli infection , Enterotoxigenic e. coli infection , Epidemic typhus , Erythema chronicum migrans , Erythema multiforme, Erythema nodosum , Escharonodulaire, Fever , Flavivirus infections, Flea-borne diseases, Flu , Gingivostomatitis, Gnathostoma hispidum infection, Gnathostoma infection, Gnathostoma spinigerum infection, Guanarito virus, H1n1 flu, Hand-foot-and-mouth disease, Hantavirus, Helicobacter cinaedi infection, Helicobacter fenneliae infection, Helminthiasis, Hepatitis , Herpes simplex encephalitis , Histoplasmosis, Hookworm , Hypersensitivity pneumonitis, India tick typhus, Indian tick fever, Infectious diarrhea, Infectious mononucleosis, Infective endocarditis, Influenza a , Influenza b , Influenza, Invasive group a streptococcal disease, Isopsoriasis , Israeli spotted fever, Kenya fever , Kenya tick typhus, Kenya tick-bite fever, Legionnaires’ disease , Liver abscess, Lung abscess, Lyme disease, Lymphocytic choriomeningitis , Machupo virus, Marseilles fever, Mediastinitis, Mediterranean spotted fever, Meningococcemia, Mesenteric adenitis, Mononucleosis , Mosquito-borne diseases, Mountain fever , Mountain tick fever , Mumps, Mycobacterial infections, Mycobacterium xenopi , Nasopharyngitis, Newcastle disease, Ocular vaccinia , Paragonimiasis, Paratyphoid fever, Pelvic abscess , Pelvic inflammatory disease, Perirectal abscess, Pharyngoconjunctival fever , Pneumocytosis, Pneumonia, Pneumonitis , Polio, Poxviridae disease , Protozoan infections, Pseudomembranous colitis , Psittacosis, Q fever, Queensland tick typhus, Rabies, Renal carbuncle, Respiratory tract infections, Rhinovirus infection, Rhodococcus equi , Rocio encephalitis, Rubella, Sars, Secondary syphilis, Shingles, Simian b virus infection , Sindbis fever , Spirochetes disease, Stachybotrys chartarum , Tick-borne encephalitis , Tonsilitis , Tooth abscess, Toxoplasmosis, Transverse myelitis, Traveler’s diarrhea, Trypanosomiasis, Tuberculosis, Type a influenza, Type b influenza, Type c influenza, Typhoid fever, Upper respiratory infection, Urinary tract infection, Varicella virus antenatal infection, Varicella zoster, Vibrio vulnificus infection, Viral digestive infections, West african trypanosomiasis , West nile encephalitis, West nile fever , Western equine encephalitis, Whooping cough , Worm conditions , Yaws
Musculoskeletal/Orthopedic	Acute myelofibrosis, Acute panmyelosis, Hip cancer, Inflammatory myofibroblastic tumors , Mixed connective tissue disease , Pelvic abscess , Pelvic inflammatory disease, Ventral hernia
Neurologic	Acute bokhoror , Acute viliuisk encephalitis, Acute viliuisk encephalomyelitis, African sleeping sickness, Brachial neuritis, California encephalitis, Chronic fatigue syndrome , Colorado tick encephalitis, Dermatomyositis, Dermatostomatitis, Eastern equine encephalitis, Eijkman’s syndrome, Encephalitis, Fatigue, Herpes simplex encephalitis , Inadequate sleep, Marchiafava-micheli disease, Myelitis, Opsoclonus myoclonus , Rocio encephalitis, Slowly progressive bokhoror , Slowly progressive viliuisk encephalitis, Slowly progressive viliuisk encephalomyelitis, Space adaptation syndrome , Tick-borne encephalitis , Treponema infection, Winkelman bethfe pfeiffer syndrome
Nutritional/Metabolic	Bicarbonate deficit , Burnett’s syndrome, Cyclospora cayetanenis food poisoning, Diabetes , Organic acidemia , Peanut allergy, Type 2 diabetes, Wheat intolerance
Obstetric/Gynecologic	Acute fatty liver of pregnancy , Autoimmune oophoritis, Breast abscess, Fitz-hugh syndrome, Hellp syndrome
Oncologic	Aggressive nk-cell leukaemia, Back tumour, Blood cancers , Chronic leukemia , Classical hodgkin disease , Colon cancer, Distal colorectal cancer, Follicular dendritic cell tumor , Hamartomatous colorectal cancer, Hepatocellular carcinoma, Hepatoma, Hip cancer, Hodgkin’s disease , Hypereosinophilic syndrome, Inflammatory myofibroblastic tumors , Kidney cancer , Leukemia, Liver cancer, Lymphadenopathy, Lymphocyte depletion hodgkin’s disease , Lymphocytic choriomeningitis , Lymphoma, Mixed cellularity hodgkin’s disease , Nodular sclerosing hodgkin’s lymphoma, Ovarian cancer, Papillary renal cell carcinoma, Philadelphia-negative chronic myeloid leukemia, Pleuropulmonary blastoma , Proximal colorectal cancer, Renal cell carcinoma , Rib tumor, Spleen cancer , Spleen neoplasm, Sporadic colorectal cancer, Squamous cell skin cancer
Ophthalmologic	Acute posterior multifocal placoid pigment, Bruch’s disease, Ocular vaccinia
Overdose/Toxicity	Herbal agent overdose, Hypervitaminosis a , Sulfone syndrome, Zieve syndrome
Psychiatric	Depression, Depressive disorders, Discontinuation syndrome, Dysthymia, Emotional trauma, Stress
Pulmonary	Acute bronchitis , Acute lower respiratory conditions, Acute pneumonia, Bronchitis, Chronic obstructive pulmonary disease, Coccidioidomycosis , Familial interstitial fibrosis, Farmer’s lung, Hamman-rich syndrome, Histoplasmosis, Hypersensitivity pneumonitis, Legionnaires’ disease , Lung abscess, Mediastinitis, Pleuropulmonary blastoma , Pneumocytosis, Pneumonia, Pneumonitis , Polymer fume fever , Pulmonary anthrax , Renal tuberculosis, Respiratory tract infections, Sarcoidosis, Silicosis, Tuberculosis, Upper respiratory infection, Whooping cough , Yellow nail syndrome
Renal/Electrolyte	Acute renal failure, Chronic interstitial nephritis, Chronic pyelonephritis , Cope’s syndrome, Hyponatremia, Kidney cancer , Milk-alkali syndrome , Munk disease , Nephrotic syndrome, Papillary renal cell carcinoma, Pyelonephritis, Renal carbuncle, Renal cell carcinoma , Renal failure, Renal tuberculosis
Rheumatology/Immunology/Allergy	Acute rheumatic fever, Allergic rhinitis , Bowel bypass syndrome, Bowel-associated dermatosis-arthritis syndrome, Brachial neuritis, Castellani syndrome, Conor’s disease, Dermatomyositis, Dermatostomatitis, Felty syndrome, Human adjuvant disease, Idiopathic diffuse interstitial fibrosis, Lupus, Mixed connective tissue disease , Mucha-habermann syndrome, Multifocal fibrosclerosis, Peanut allergy, Perennial allergic rhinitis, Perennial rhinitis, Polymyalgia rheumatica , Rheumatic fever, Rheumatoid arthritis, Sarcoidosis, Seasonal allergic rhinitis, Sulfone syndrome, Systemic lupus erythematosus, Wheat intolerance , Yaws
Sexual	Aids, Chronic active hepatitis, Secondary syphilis
Trauma	Ventral hernia
Urologic	Cope’s syndrome, Milk-alkali syndrome , Prostate disorders, Urinary tract infection
Miscellaneous	No underlying causes

Causes by alphabetical order

References

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