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Eye pain

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2]

Overview

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Aditya Govindavarjhulla, M.B.B.S. [2]

Overview

Pain in the may be described as a burning, throbbing or stabbing sensation in or around the eye.[3] It can result from within the eye or from the structures around it. It can even be due to some other systemic problem or drugs used for other condition. Severe pain in the eye may be an alarming symptom to seek medical help. The goal of the primary care physician in case of eye pain will be to assess whether it is an emergency or benign condition. Pain can be due surface problems causing pain with every blink. It can even be due to the deep structures in the globe causing retrobulbar pain with movements of the eye.

Pathophysiology

Eye pain is caused by the inflammation of layers of eye. It is carried to the brain by different nerves of eye and face. Incresaed intra ocular pressure also causes pain in the eye.

Epidemiology and Demographics

There is no significant difference in occurrence of eye pain the population. It depends on the occurrence of different diseases in that population.

Risk Factors

There are no specific risk factors for eye pain. Several conditions cause inflammation and infection of eye causing eye pain.

Causes

There are multiple conditions which lead to eye pain. It is commonly confused with other symptoms like headache, sinus pain. Common causes include: Blepharitis , Corneal abrasion, Conjunctivitis , Stye, Foreign bodies, Glaucoma , Uveitis, Optic neuritis and Sinusitis.

Natural History, Prognosis and Complications

Progression of eye pain depends largely on the cause of the pain. Every cause has its own prognosis. The role of physician is to identify the cause and do the needful.

Diagnosis

History

There are certain important clues that can be obtained from history of the patients. Enquiry of patient certain things will help in accaurate diagnosis and treatment.

Physical Examination

There are number of features we will observe in a painful eye depending upon the cause. various tests are performed to evaluate eye pain.Physical examination is very important in evaluation of cause and determining the prognosis. Several tests including opthalmoscopy, slit lamp examination, tonometry are done.

Laboratory Tests

There are only few tests which help in prognosis of eye pain.

Chest X Ray

This is a non specific test for eye pain. It is done only if associated respiratory symptoms are present.

References

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Pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Eye pain is caused by the inflammation of layers of eye. It is carried to the brain by different nerves of eye and face. Incresaed intra ocular pressure also causes pain in the eye.

Pathophysiology

Pain in the eye is due to disturbance of its layer. Surface layers of the eye are very sensitive. Inflammations and infections of these layers cause severe pain. They cause pain with every blink. Surface layers are innervated by nerve endings which act as receptors for pain. With disturbance in these layers the nerve endings get irritated and pain is perceived by the individual. Inner layers can also be inflamed due to many causes like autoimmune conditions or any systemic inflammatory conditions which leads to profuse inflammation and severe pain.

In certain conditions there in increase in IOP(intraocular pressure) which presses over the optic nerve the light sensitive layer of the eye leading to pain. Certain drugs cause increase in pressure and result in eye pain. Inflammatory process inside the eye leads to increase in pressure causing pain.

Pain is mediated by the first branch of Vth nerve i.e. Ophthalmic branch, which carried pain sensation from cornea and uveal tract. Facial nerve carries pain sensation from surrounding structures of eye. Optic nerve is primarily related to compressive insults and inflammation of the nerve.

References

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Epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

There is no significant difference in occurrence of eye pain the population. It depends on the occurrence of different diseases in that population.

Epidemiology and Demographics

Conjunctivitis is one of the major causes of eye pain it greatly affects the demographics. Infectious conjunctivitis may be differing in distribution. In neonates they may pick up infectious agent from birth canal.sexual practices have to be considered in teenagers and sexually active groups.Male and female have equal resistance to infections. Certain professions like people working in school may pick up some infection. Viral causes can lead to epidemic in schools . military organizations.

Inflammations due to allergen can be noticed only during certain seasons and climates only.

Trauma to eye is a significant causative factor for eye pain[1]. People wearing contact lenses are also at risk population.Inflammation of eyelids is seen in aged population.

References

  1. Shields T, Sloane PD (1991). “A comparison of eye problems in primary care and ophthalmology practices”. Fam Med. 23 (7): 544–6. PMID 1936738.

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Risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

There are no specific risk factors for eye pain. Several conditions cause inflammation and infection of eye causing eye pain.

Risk Factors

Most common cause of eye pain include inflammation of conjunctiva, cornea and uveal tract. Risk factors for these include:

  • Allergen exposure
  • Infections
  • Use of contact lenses
  • Warm, humid climate
  • Use of corticosteroid eye drops
  • Reduced immunity
  • Eye injury
  • Autoimmune conditions
  • Hyperopia

Use of certain drugs causes increase in intraocular pressure keep at risk of eye pain.

References

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Causes

Common Causes | System based | Alphabetical order

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

There are multiple conditions which lead to eye pain. It is commonly confused with other symptoms such as headache and sinus pain.

Causes

Common Causes

Causes by Organ System

Cardiovascular Atheroembolism, Azinphos-methyl, Berry aneurysm, Carotid-cavernous fistula, Cholesterol crystal embolism, Cranial arteritis, Eales disease, Ocular ischemic syndrome, Retinal artery thrombosis, Temporal arteritis, Thrombosis, Wegener’s granulomatosis
Chemical / poisoning |1-amino-2-propanol, 1-pentanethiol, 2-amino-2-methylpropanol, 2-aminopyridine, 2,4,6-trichlorophenol, 2,4,6-trinitrotoluene, 3-aminopyridine, 4-aminopyridine, Acitretin, Adam and eve poisoning, Adipic acid, Agapanthus poisoning, Allyl chloride, Allyl glycidyl ether, Allylamines, Ammonium nitrate, Ammonium sulfamate, Anisole, Antimony, Barium nitrate, Benzaldehyde, Boston ivy poisoning, Bromates, Bufotenine poisoning, Butylamines, Caladium poisoning, Calcium oxalate poisoning, Calla poisoning, Caulking products, Century plant poisoning, Chemical allergy, Chemical burns, Cobra poisoning, Crown of thorns poisoning, Cyclohexanol, Devil’s ivy poisoning, Dieffenbachia poisoning, Elephant’s-ear poisoning, Ethylamine, Ethylenediamine, Euphorbiaceae plant poisoning, Ginger lily poisoning, Golden club poisoning, Green dragon poisoning, Hexachlorobutadiene, Hexachlorocyclopentadiene, Hexane, Hot pepper poisoning, Hydrogen chloride, Hydrogen fluoride, Hydrogen sulfide, Italian arum poisoning, Lodoxamide, Marine toxins, Methyl bromide, Methyl ethyl ketone, Methyl isocyanate, Methyl mercaptan, Methylene chloride, Millipede poisoning, Morpholine, N-methyl-2-pyrrolidone, Nephthytis poisoning, Nitric acid, Nitrofen, Nitrogen dioxide, Nitrophenol, Para-dichlorobenzene, Paraphenylenediamine, Pentaborane, Pentachlorophenol, Peruvian lily poisoning, Phosgene oxime exposure, Phosphine, Popcorn tree poisoning, Potassium permanganate, Propylene glycol, Pyridine, Selenium dioxide, Sodium azide, Sodium hypochlorite, Split-leaf philodendron poisoning, Sulfur trioxide, Tetrachloroethane, Tetrachloroethylene, Tetrahydrofuran, Tetryl, Thiram, Thorium, Tin, Titanium, Trichloroethane, Turpentine oil, Vinyl choride, Xylene, Zinc phosphide
Dermatologic Benign mucosal pemphigoid, Erythema multiforme, Linear IgA dermatosis, Rosacea, Stevens-Johnson syndrome, Sweet syndrome
Drug Side Effect Aflibercept, Alitretinoin, Amlodipine, Atropine, Besifloxacin, Bimatoprost, Brimonidine, Brinzolamide, Carboxymethyl cellulose, Carteolol, Dipivefrin, Epirubicin, Ganciclovir, Gentamicin, Hydrazine, Hyoscyamine, Idarubicin, Idoxuridine, Ingenol mebutate, Latanoprost , Levofloxacin, Metipranolol, Mitomycin, Moxifloxacin, Natamycin, Nepafenac, Nifedipine, Nitrendipine, Ofloxacin , Ocriplasmin, Pegaptanib, Peginterferon alfa-2a, Pentazocine, Prednisolone, Ranibizumab, Rimexolone, Travoprost, Voriconazole, Zaleplon, Zoledronic acid
Ear Nose Throat Carotid-cavernous fistula, Cavernous sinus thrombosis, Charlin’s syndrome, Dacryoadenitis, Dacryocystitis, Nasal congestion, Sinusitis, Tolosa-Hunt syndrome
Endocrine Graves’ Disease
Environmental No underlying causes
Gastroenterologic Inflammatory bowel disease
Genetic Dentatorubral pallidoluysian atrophy, Hereditary keratitis, Keratitis fugax hereditaria, Retinoblastoma, Stickler syndrome, X-linked agammaglobulinemia
Hematologic Cavernous sinus thrombosis, Langerhans cell histiocytosis, Mycosis fungoides, Thrombocytosis
Iatrogenic Ocular surgery
Infectious Disease Acanthamoeba infection, Adenovirus infection, Amoebiasis, Angiostrongyliasis, Aspergillosis, Bacterial conjunctivitis, Bacterial endophthalmitis, Candida infection, Chlamydia, Corneal infection, Cryptosporidiosis, Cysticercosis, Cytomegalovirus retinitis, Dendritic ulcer, Dengue virus infection, Ebola, Flavivirus infection, Flu-like infection, Flu, Fungal conjunctivitis, Fusarium keratitis, Herpes simplex virus infection, Herpes zoster, Herpetic keratitis, Immune reconstitution inflammatory syndrome, Infected chalazion, Infected pterygium, Infectious keratitis, Influenza, Invasive aspergillosis, Klebsiella pneumoniae infection, Measles, Microsporidiosis, Ocular larva migrans, Ocular vaccinia, Orbital cellulitis, Periorbital cellulitis, Postherpetic neuralgia, Rhizopus, Scedosporium infection, Shingles, Toxoplasmosis, Trachoma, Trichinosis, Tuberculous uveitis, Vaccinia keratitis, Viral conjunctivitis, West nile virus infection, Whipple’s disease
Musculoskeletal / Ortho Barre-lieou syndrome, Trochleitis, Stickler syndrome, Zygomatic mastoiditis
Neurologic Barre-lieou syndrome, Berry aneurysm, Boehm syndrome, Charlin’s syndrome, Classic migraine, Cluster headache, Cranial arteritis, Cranial neuralgia, Dentatorubral pallidoluysian atrophy, Facioplegic migraine, Meningitis, Migraine, Multiple sclerosis, Neuralgia, Ophthalmoplegic migraine, Optic neuritis, Optic neuropathy, Paroxysmal extreme pain disorder, Phantom pain, Pineal teratoma, Pinealoma, Pineoblastoma, Postherpetic neuralgia, Raised intracranial pressure, Retinitis pigmentosa, Subdural hematoma, SUNA headache, SUNCT headache, Sympathetic ophthalmia, Trigeminal autonomic cephalalgia, Trigeminal neuralgia
Nutritional / Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic Choroidal melanoma, Eye tumor, Intraocular neoplasm, Langerhans cell histiocytosis, Mycosis fungoides, Orbit tumor, Orbital lymphangioma, Orbital lymphoma, Orbital tumor, Pineal teratoma, Pinealoma, Pineoblastoma, Rhabdomyosarcoma of the orbit, Uveal melanoma
Opthalmologic Acanthamoeba infection, Acute angle-closure glaucoma, Acute blepharitis, Acute glaucoma, Acute iritis, Acute keratitis, Acute tubulointerstitial nephritis and uveitis syndrome, Acute zonal occult outer retinopathy, Adenovirus infection, Allergic conjunctivitis, Amoebiasis, Angiostrongyliasis, Angle-closure glaucoma, Aniseikonia, Anterior uveitis, Asthenopia, Bacterial conjunctivitis, Bacterial endophthalmitis, Band keratopathy, Basement membrane corneal dystrophy, Birdshot chorioretinopathy, Blepharitis, Boehm syndrome, Brown-McLean syndrome, Carotid-cavernous fistula, Chalazion, Charlin’s syndrome, Choroidal melanoma, Ciliochorodial detachment, Closed-angle glaucoma, Cogan-Guerry map-dot-fingerprint corneal dystrophy, Computer vision syndrome, Conjunctivitis, Contact lens overwear, Corneal abrasion, Corneal dystrophy, Corneal erosion, Corneal flash burns, Corneal foreign bodies, Corneal infection, Corneal transplant rejection, Corneal ulcer, Cytomegalovirus retinitis, Decreased lacrimation, Dendritic ulcer, Dengue virus infection, Dry eye, Dust in the eye, Eales disease, Ectopia lentis, Ectropion, Endophthalmitis, Entropion of eyelid, Episcleritis, Exophthalmos, Eye injury, Eye strain, Eye tumor, Eyelash in the eye, Follicular conjunctivitis, Fragment lodged in eye, Fuchs corneal dystrophy, Fungal conjunctivitis, Fusarium keratitis, Ghost cell glaucoma, Glaucoma, Grayson-wilbrandt syndrome, Hereditary keratitis, Herpetic keratitis, Hordeolum externum, Hyperopia, Hyphema, Hypopyon, Incorrect glasses, Infected chalazion, Infected pterygium, Infectious keratitis, Infrequent blinking, Ingrowing eyelash, Intraocular hemorrhage, Intraocular neoplasm, Iridocyclitis, Iritis, Keratitis fugax hereditaria, Keratitis, Keratoconjunctivitis sicca, Keratoconus, Lacrimal canaliculitis, Lattice dystrophy, Lens disorders, Macular dystrophy, Map-dot-fingerprint dystrophy, Meibomitis, Multifocal choroiditis, Multifocal fibrosclerosis, Narrow-angle glaucoma, Ocular cicatricial pemphigoid, Ocular convergence spasm, Ocular ischemic syndrome, Ocular laceration, Ocular larva migrans, Ocular surgery, Ocular vaccinia, Oculogyric crisis, Open-angle glaucoma, Ophthalmitis, Ophthalmoplegia, Ophthalmoplegic migraine, Optic neuritis, Optic neuropathy, Orbit tumor, Orbital cellulitis, Orbital inflammatory pseudotumor, Orbital lymphangioma, Orbital lymphoma, Orbital tumor, Papilledema, Papillitis, Penetrating eye injury, Periorbital cellulitis, Phantom eye syndrome, Photokeratitis, Posner-Schlossman syndrome, Primary infantile glaucoma, Recurrent corneal erosion, Refractive errors, Retinal artery thrombosis, Retinal detachment, Retinitis pigmentosa, Retinoblastoma, Rhabdomyosarcoma of the orbit, Rubeosis iridis, Salzmann nodular degeneration of cornea, Scleritis, Sclerokeratitis, Seborrheic blepharitis, Stickler syndrome, Stye, Subconjunctival hemorrhage, Sympathetic ophthalmia, Thygeson superficial punctate keratitis, TINU syndrome, Tolosa-Hunt syndrome, Traumatic hyphema, Trochleitis, Tuberculous uveitis, Tubulointerstitial nephritis and uveitis, Uveal melanoma, Uveitis, Vaccinia keratitis, Vernal keratoconjunctivitis, Viral conjunctivitis
Overdose / Toxicity No underlying causes
Psychiatric Insomnia, Paroxysmal extreme pain disorder, Phantom eye syndrome, Phantom pain
Pulmonary No underlying causes
Renal / Electrolyte Acute tubulointerstitial nephritis and uveitis syndrome, TINU syndrome, Tubulointerstitial nephritis and uveitis, Wegener’s granulomatosis
Rheum / Immune / Allergy Allergic conjunctivitis, Animal allergy, Behcet’s disease, Chemical allergy, Corneal transplant rejection, Food additive allergy, Food allergy, Hypopyon, Immune reconstitution inflammatory syndrome, Inflammatory bowel disease, Keratoconjunctivitis sicca, Linear IgA dermatosis, Multiple sclerosis, Ocular cicatricial pemphigoid, Reiter’s syndrome, Sarcoidosis, Seronegative spondylarthropathies, Sjogren’s syndrome, Stevens-Johnson syndrome, Systemic lupus erythematosus, Temporal arteritis, Vernal keratoconjunctivitis, Wegener’s granulomatosis, X-linked agammaglobulinemia
Sexual No underlying causes
Trauma Corneal abrasion, Eye injury, Ocular laceration, Penetrating eye injury, Recurrent corneal erosion, Traumatic hyphema
Urologic No underlying causes
Dental No underlying causes
Miscellaneous Atheroembolism, Cholesterol crystal embolism, Computer vision syndrome, Contact lens overwear, Corneal flash burns, Corneal foreign bodies, Decreased lacrimation, Dry eye, Dust in the eye, Ectopia lentis, Ectropion, Entropion of eyelid, Excessive illumination, Exophthalmos, Eye strain, Eyelash in the eye, Foreign body, Fragment lodged in eye, Inadequate illumination, Incorrect glasses, Infrequent blinking, Ingrowing eyelash, Insect bite, Nasal congestion, Phantom eye syndrome, Prolonged close work, Sarcoidosis, Vernal keratoconjunctivitis

Causes in Alphabetical Order

References

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Natural history,Complications and Prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Progression of eye pain depends largely on the cause of the pain. Every cause has its own prognosis. The role of physician is to identify the cause and do the needful.

Natural History, Complications and Prognosis

Natural History

The most common causes are infection and inflammation of eye layers or surrounding structures. Infectious causes may be acute to sub acute in presentation. Viral infections may be self limiting and can cause super imposed bacterial infections. Bacterial infections need topical antibiotic therapy. Untreated infections may scar the tissue and cause ulceration.

Bacteria infection of cornea is most alarming cause of eye pain. It can cause total destruction of cornea in 2-3 days. Fungal infections are indolent and its prevalence varied from region to region.

Complications

  • Eye lid thickening
  • Corneal abrasion
  • Corneal ulceration
  • Corneal perforation
  • Inflammation of uveal tract
  • Visual loss

Prognosis

Prognosis largely depends on the type of infectious organism involved and its virulence. Immunocompetency of the individual also determines the recovery of the person.

References

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Diagnosis

Diagnosis

Symptoms | Physical Exam | Lab Tests | Chest X Ray | CT | MRI | Other Diagnostic Studies

Treatment

Treatment

Medical Therapy | Surgery Template:WH Template:WS

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