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Abdominal mass

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: John Fani Srour, M.D.

Overview

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

An abdominal mass is any localized enlargement or swelling in the human abdomen. Depending on its location, the abdominal mass may be caused by an enlarged liver (hepatomegaly), enlarged spleen (splenomegaly), protruding kidney, a pancreatic mass, a retroperitoneal mass (a mass in the posterior of the peritoneum), an abdominal aortic aneurysm, or various tumours, such as those caused by abdominal carcinomatosis and omental metastasis. The treatments depend on the cause, and may range from watchful waiting to radical surgery.

Diagnosis

History and Symptoms

The first steps in diagnosis are a medical history and physical examination. Important clues during history include weight loss, diarrhea and abdominal pain.

Physical Examination

During physical examination, the clinician must identify the location of the mass, as well as characterize its location (usually specified in terms of quadrants). The mass should be assessed for whether it is rigid or mobile. It should also be characterized for pulse or peristalsis, as these would help in further identifying the mass.

Laboratory Findings

Routine blood tests are usually the next step in diagnosis after a thorough medical history and physical examination. They should include a full blood count, blood urea nitrogen (BUN), creatinine, and liver function tests such as albumin, international normalized ratio (INR), partial thromboplastin time (PTT), serum amylase and total bilirubin (TBIL). If late-stage liver disease is suspected, then a serum glucose may be appropriate.

X Ray

KUB (kidneys, ureters, bladder) x-rays could possibly reveal free intraperitoneal air, constipation or obstruction.

CT

Abdominal CT with oral IV contrast will evaluate for bowel pathology, abscess, and hepatosplenomegaly.

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Pathophysiology

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Causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Causes

Common Causes

Causes by Organ System

Cardiovascular Abdominal Aortic Aneurysm
Chemical / poisoning No underlying causes
Dermatologic No underlying causes
Drug Side Effect No underlying causes
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic

Acute pancreatitis, Ascites, Autoimmune pancreatitis, Bezoar, Biliary atresia, Blind loop syndrome, Bowel obstruction, Cholangiocarcinoma, Cholecystitis, Choledochal cyst, Cholelithiasis, Cirrhosis, Colonic diverticulitis, Congenital hypertrophic pyloric stenosis, Congenital megacolon, Constipation, Crohn’s disease, Distal intestinal obstruction syndrome, Gastroschisis, Hepatomegaly, Hirschsprung’s disease, Liver granuloma, Palpable gallbladder Courvoisier’s sign, Pancreatic pseudocyst, Pyloric stenosis, Riedel lobe of liver, Splenosis, Toxic megacolon, Urachal cyst, Vermiform appendix, Volvulus, Wandering spleen, Yersinia enterocolitica.

Genetic Acanthocheilonemiasis , Alpha-L-iduronidase deficiency (Hurler syndrome), Alpha-L-iduronidase deficiency (Hurler-Scheie syndrome), Alpha-mannosidase deficiency, Apolipoprotein C-II deficiency, Beta thalassaemia (heterozygous), Chanarin-Dorfman disease, Chediak-Higashi disease , Cholesterol ester storage disease , Common variable hypogammaglobulinaemia, Congenital dyserythropoietic anaemia type 1, Congenital erythropoeitic porphyria, Coproporphyria, hereditary , Cruveilhier-Baumgarten syndrome, Familial alphalipoprotein deficiency, Familial histiocytic reticulosis, Familial hypertriglyceridaemia, Farber lipogranulomatosis, Fucosidosis , Fumarase deficiency , Galactose epimerase deficiency, Galactose-1-phosphate uridyltransferase deficiency, Gangliosidosis GM1 type 1, Gangliosidosis GM1 type 3, Gangliosidosis GM3, Gaucher disease , Geleophysic dysplasia, Glucose phosphate isomerase deficiency, Glycogenosis type 4, Granulocyte colony stimulating factor, Haemochromatosis , Haemoglobin C disease, Haemoglobin E disease, Haemoglobin SC disease, Haemolytic disease of the newborn, Hereditary spherocytosis , Iduronate-2-sulfatase deficiency, Iminodipeptiduria Kartagener syndrome , Long chain hydroxyacyl-CoA dehydrogenase deficiency, Macrophage activation syndrome, McLeod phenotype, Mevalonate kinase deficiency, Mucopolysaccharidosis VI , Neutrophilia, hereditary, Niemann-Pick disease type B, Niemann-Pick Disease, Type C, Norrbottnian Gaucher disease, Salla disease , Sandhoff disease , Sanfilippo disease, Sarcoidosis , Sickle cell disease, Zimmermann-Laband syndrome.
Hematologic Chediak-Higashi disease , Extramedullary haemopoiesis, Familial histiocytic reticulosis, Fanconi-Bickel syndrome, Haemochromatosis , Sickle cell crisis , Haemoglobin C disease, Haemoglobin E disease, Haemoglobin SC disease, Haemolytic disease of the newborn, Hereditary spherocytosis , Mastocytosis , Myelofibrosis , Hereditary neutrophilia, Vitamin B12 deficiency.
Iatrogenic No underlying causes
Infectious Disease Abscess, Actinomyces, Alveolar hydatid disease, Bartonellosis, Brucellosis, Cat scratch fever, Entamoeba histolytica, Gallbladder empyema, kala-azar, Leishmaniasis, Kaposi sarcoma, Liver abscess, Liver granuloma, Lymphogranuloma venereum, Malaria, Mycobacterium tuberculosis, Oesophagostomiasis, Pancreatic abscess, Pelvic inflammatory disease, Psittacosis, Relapsing fever , Syphilis congenital, Tertiary syphilis, Toxoplasmosis congenital, Yersinia enterocolitica.
Musculoskeletal / Ortho No underlying causes
Neurologic No underlying causes
Nutritional / Metabolic No underlying causes
Obstetric/Gynecologic Choriocarcinoma, Ectopic pregnancy, Endometriosis, Meigs syndrome, Pelvic inflammatory disease, Pregnancy, Uterine enlargement, Uterine leiomyoma.
Oncologic Adrenal tumor, Brenner tumor, Burkitt’s lymphoma, Carcinoid tumours, Cholangiocarcinoma, Choriocarcinoma, Chronic myelogenous leukemia, Colorectal cancer, Desmoplastic small round cell tumor, Endodermal sinus tumor, Gallbladder benign tumors, Gallbladder cancer, Gastrointestinal stromal tumor, Germ cell tumor, Hairy cell leukaemia, Hamartoma, Hemangioendothelioma, Hemangiopericytoma, Hepatic adenoma, Hepatoblastoma, Histiocytosis X, Hodgkin’s lymphoma,

Kaposi sarcoma, Kidney cancer, Krukenberg tumor, Leiomyoma, Liposarcoma, Metastatic Liver cancer, Primary Liver cancer, Meigs syndrome, Nephroblastoma, Neurilemmoma, Neuroendocrine tumor, Non-Hodgkin lymphoma, Oncocytoma, Ovarian cancer, Pancreatic cancer, Pancreatic islet cell tumors, Phaeochromocytoma, Plexosarcoma, POEMS syndrome, Pseudomyxoma peritonei, Renal cell carcinoma, Renal oncocytoma, Rhabdoid tumor, Sacrococcygeal teratoma, Sickle cell crisis, Sister Mary Joseph nodule, Small bowel lymphoma, Spleen lymphoma, Stomach cancer, Transitional cell carcinoma, Uterine leiomyoma, Wilm’s tumor.

Opthalmologic No underlying causes
Overdose / Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal / Electrolyte No underlying causes
Rheum / Immune / Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic Bladder distention, Cryptorchidism, Hydronephrosis, Kidney cancer, Pelvic kidney, Polycystic kidney disease, Renal cell carcinoma, Renal oncocytoma, Renal transplantation, Transitional cell carcinoma, Urine retention, Varicocele, Wilm’s tumor.
Miscellaneous No underlying causes

Causes in Alphabetical Order


References


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Differentiating Abdominal Mass from other Diseases

Differential Diagnosis

  • Abdominal aortic aneurysm can cause a pulsating mass around the navel.
  • Bladder distention (urinary bladder over-filled with fluid) can cause a firm mass in the center of the lower abdomen above the pelvic bones, in extreme cases it can reach as far up as the navel.
  • Cholecystitis can cause a very tender mass that is felt below the liver in the right-upper quadrant (occasionally).
  • Colon cancer and Volvulus can cause a mass at any location in the abdomen.
  • Crohn’s disease or bowel obstruction can cause many tender, sausage-shaped masses anywhere in the abdomen.
  • Diverticulitis can cause a mass that is usually located in the left-lower quadrant.
  • Gallbladder tumor can cause a tender, irregularly shaped mass in the right-upper quadrant.
  • Hydronephrosis (fluid-filled kidney) can cause a smooth, spongy-feeling mass in one or both sides or toward the back (flank area).
  • Kidney cancer can sometimes cause a mass in the abdomen.
  • Liver cancer can cause a firm, lumpy mass in the right upper quadrant.
  • Liver enlargement (hepatomegaly) can cause a firm, irregular mass below the right rib cage, or on the left side in the stomach area.
  • Neuroblastoma, a cancerous tumor, often found in the lower abdomen, that mainly occurs in children and infants.
  • Ovarian cyst can cause a smooth, rounded, rubbery mass above the pelvis in the lower abdomen.
  • Pancreatic abscess can cause a mass in the upper abdomen in the epigastric area.
  • Pancreatic pseudocyst can cause a lumpy mass in the upper abdomen in the epigastric area.
  • Renal cell carcinoma can cause a smooth, firm, but not tender mass near the kidney (usually only affects one kidney).
  • Spleen enlargement (splenomegaly) can sometimes be felt in the left-upper quadrant.
  • Stomach cancer can cause a mass in the left-upper abdomen in the stomach area (epigastric) if the cancer is large.
  • Uterine leiomyoma (fibroids) can cause a round, lumpy mass above the pelvis in the lower abdomen (sometimes can be felt if the fibroids are large).
  • Ureteropelvic junction obstruction can cause a mass in the lower abdomen.
  • Intramural mass (Rectus hematoma) can present as a mass in the abdominal area, but can be distinguished with physical examination. Ask the patient to lift his head up from pillow and palpate the mass. When the abdominal muscles get tensed, the abdominal mass moves away while the intramural mass can still be palpable.[1]
  • [[category:Needs review]]

References

  1. The Abdomen, Perineum, Anus, and Rectosigmoid. In: Suneja M, Szot JF, LeBlond RF, Brown DD. eds. DeGowin’s Diagnostic Examination, 11e. McGraw Hill; Accessed July 28, 2021. https://accessmedicine.mhmedical.com/content.aspx?bookid=2927&sectionid=247756769

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Epidemiology and Demographics

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Risk Factors

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Natural History, Complications and Prognosis

Natural History

Many abdominal masses are discovered incidentally during routine physical examination. When they are present symptomatically, abdominal masses are most frequently associated with pain or digestive problems. However, depending on the cause, masses may be associated with other signs and symptoms.


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Diagnosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | X Ray | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case Studies

Case #1


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